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EB Research - Methodological Research in Epidemiology

Biomarker/Analytical Development: Mixtures of Environmental Exposures

With the ever changing production of consumer products, so too are the public's environmental exposure to potential toxicants continuously changing. Often these exposures occur in mixtures, which in turn lead to statistical issues of colinearity and high dimensionality which make it difficult or impossible to distinguish the influences of individual chemicals on health outcomes when studying a chemicals' public health impact.

Researchers here have worked towards developing methods that allow for assessing the effects of these chemicals jointly, reflecting the reality of the public's actual exposure profile, rather than estimating the individual effects of each. These methodological developments are motivated by the understanding of an individual's exposure profile where interactions are implicit. In an effort to overcome the analytical challenges that often leave issues of mixtures ignored, a collaborative effort funded by the American Chemistry Council has been organized with the goal of providing the methodological tools necessary to assess and address the issues of mixtures in the assessment of environmental exposures and their potential role in disease.

Principal Investigator

Enrique F. Schisterman, Ph.D.

DIPHR Collaborators

Selected Publications

  • Buck Louis GM, Sundaram R. Exposome: Time for Transformative Research: Invited Commentary. Statistics and Medicine 2012;31(22):2569-2575. PMID: 22969025
  • Buck Louis GM, Yeung E, Sundaram R, Laughon SK, Zhang C. The exposome – exciting opportunities for discoveries in reproductive and perinatal epidemiology. Paediatric and Perinatal Epidemiology,2013; 27(3):229-36. PMID: 23574410
Last Reviewed: 09/09/2014

Contact Information

Name: Dr Enrique Fabian Schisterman
Chief and Senior Investigator
Epidemiology Branch
Phone: 301-435-6893
Fax: 301-402-2084

Staff Directory
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology