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Biostatistics and Bioinformatics Branch (BBB)

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Software of Statistical Genetics by Dr. Fan's group

(1) R codes for Gene Level Meta-analysis of Quantitative Pleiotropic Traits with Multivariate Functional Linear Models

(2) R codes for Cox FR LRT: a Gene-based Association Method for Censored Traits Via Functional Regressions, R. Fan and Q. Yan

(3) R Codes for Gene Level Meta-analysis of Quantitative Traits by Functional Linear Models, R. Fan, 2015.

(4) R codes for Gene Level Meta-analysis of Dichotomous Traits by Generalized Functional Linear Models, R. Fan

(5) Datasets to run functional regression models in (6), (7), and (8) below

(6) Pleiotropy Analysis of Quantitative Traits at Gene Level by Multivariate Functional Linear Models, R. Fan and Y. Wang

(7) Generalized Functional Linear Models for Gene-based Case-Control Association Studies, R. Fan and Y. Wang

(8) Functional Linear Models for Association Analysis of Quantitative Traits, by R. Fan and Y. Wang

(9) Association analysis of complex diseases using triads, parent-child dyads and singleton monads, by R. Fan and A. Lee

Joint_Association_Analysis_web

Count_Triad_Dyad_Monad

(10) Longitudinal association analysis of quantitative traits, R. Fan, 2015

(11) R codes for Entropy-based Information Gain Approaches to Detect Gene-Gene and Gene-Environment Interactions/Correlations of Complex Diseases, R. Fan, 2015

(12) Hotelling T^2 Tests, by R. Fan and M. Knapp

(a) Hotelling T^2 Tests Based on Population Case Control Data

(b) Hotelling T^2 Tests Based on Nuclear Trio Family Data

(c) Hotelling T^2 Tests Based on Sib-ship Data

(13) Software to Detect Positive Selection in the Human Genome, by R. Fan and M. Zhong

(a) Extended Homozygosity Score Test (EHST)

An example of HapMap II data:

(b) A Cross-population Extended Haplotype-based Homozygosity Score Test (xp-EHHST)

An example of HapMap II data:

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​​Contact Information

Name: Dr Aiyi Liu
Acting Chief and Senior Investigator
Biostatistics and Bioinformatics Branch
Phone: 301-435-6952
E-mail: liua@mail.nih.gov

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