Zhen Chen, PhD

Researcher ID: M-3936-2017
ORCID ID: orcid.org/0000-0002-9946-1362

Biostatistics and Bioinformatics Branch
Division of Intramural Population Health Research
Eunice Kennedy Shriver National Institute of Child Health & Human Development
National Institutes of Health
6710B Rockledge Dr., Room 3212
Bethesda, Maryland 20892
zhen.chen@nih.gov

Education

2001 Ph.D., Statistics, University of Connecticut, Storrs, Connecticut
1996 M.A., Economics, University of Connecticut, Storrs, Connecticut
1991 B.A., Economics, People's University of China, Beijing, China

Academic & Research Experience

2009-present Investigator, Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health
2008-2009 Staff Scientist, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health
2003-2008 Assistant Professor, Department of Biostatistics & Epidemiology, University of Pennsylvania, 2003-2008
2001-2003 Research Fellow, Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, 2001-2003

Mentoring

National Institutes of Health

2016-present Mentor to postdoctoral Visiting Fellow Yu-Bo Wang (University of Connecticut)
2015-present Co-mentor (with Germaine Louis) to predoctoral fellow Francesca Branch (George Washington University
2013-2014 Co-mentor (with Germaine Louis) to NIH Graduate Partnership Program fellow Uba Backonja (University of Wisconsin), funded by the National Institute of Nursing Research
2013-2014 Co-mentor (with Germaine Louis) to MPH candidate Alexandra Goldstone (George Washington University)
2013-2016 Mentor to postdoctoral Visiting Fellow Beom Seuk Hwang (Ohio State University), NICHD
2013 Mentor to summer intern Susan Jin (Yale University)
2011 Mentor to summer intern Elande Baro (University of Maryland at Baltimore County)
2011-2013 Mentor to postdoctoral Visiting Fellow Yunlong Xie (University of Iowa)
2009-2011 Co-mentor (with Albert Paul) to postdoctoral Visiting Fellow Bo Zhang (University of Minnesota)

University

2013-2015 Ph.D. Thesis Committee member for Elande Bara in Statistics, University of Maryland at Baltimore County
2007-2008 Ph.D. Thesis Committee member for Chengcheng Liu in Biostatistics, University of Pennsylvania
2007-2008 Ph.D. Thesis Committee member for Sharon Meropol in Epidemiology, University of Pennsylvania
2005-2007 M.S. Thesis mentor to Bing Cai in Biostatistics, University of Pennsylvania
2004-2006 Ph.D. Thesis Committee member for Peng Zhang in Statistics, University of Pennsylvania Wharton School of Business
2003-2006 Ph.D. Thesis Committee member for Julia Lin in Biostatistics, University of Pennsylvania

Professional Activities

Editorial Positions

2015-present Associate Editor, Statistics in Biosciences
2013-2015 Co-Editor, Applied Statistics in Biomedicine and Clinical Trials Design

Journal Peer Review

Medical/Epidemiological journals

American Journal of Epidemiology; Andrology; Annals of Epidemiology; Contraception; Epidemiology; Fertility and Sterility; Journal of the American Medical Association

Statistical journals

Annals of Statistics; Biometrics; Biostatistics; Computational Statistics and Data Analysis; International Statistical Review; Journal of Computational and Graphical Statistics; Lifetime Data Analysis; Statistical Methods in Medical Research; Statistics in Medicine; Statistical Sinica; Statistics in Biosciences; Naval Research Logistics

Grant Reviewer

2005-2008 Ad hoc reviewer, the Clinical Trials Scientific Review and Monitoring Committee, University of Pennsylvania Cancer Center
2004-2005 Ad hoc reviewer, the Center for Health Equity Research and Promotion, Department of Veterans Affairs
2012 Ad hoc reviewer, the National Standard for Normal Fetal Growth Data Coordinating Center, Eunice Kennedy Shriver National Institute of Child Health & Human Development

Committee & Advisory Boards Appointments

2017 Member, Search Committee for Chief and Senior Investigator in Biostatistics and Bioinformatics Branch, Eunice Kennedy Shriver National Institute of Child Health & Human Development
2014-2016 Elected member, Board of Directors, International Chinese Statistical Association
2013 Member, Applied Statistics Symposium Program Committee, International Chinese Statistical Association
2013 Member, Applied Statistics Symposium Local Committee, International Chinese Statistical Association
2012-now Member, Data Safety Monitoring Committee, Eunice Kennedy Shriver National Institute of Child Health & Human Development intramural clinical research program
2012-2014 Member, Regional Advisory Board, International Biometric Society Eastern North American Region
2011-2012 Member, Program Committee, Statistics in Biomedical Research: Making and Translating New Discoveries, an NIH Biostatistics Symposium
2011 Member, Search Committee for tenure track Investigator in Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health & Human Development
2011 Member, Ethics Inquiry Committee (NIH-11-03), NIH Division of Intramural Research
2010-2011 Biostatistics, Epidemiology, & Research Design Key Function Committee of the NIH Clinical and Translational Science Award Initiative
2006-2008 Member, Impact Committee, Department of Biostatistics and Epidemiology, University of Pennsylvania
2006-2008 Member, Faculty Appointments Committee, Department of Biostatistics and Epidemiology, University of Pennsylvania
2005-2007 Member, Biostatistics Applied Research Forum Committee, Department of Biostatistics and Epidemiology, University of Pennsylvania
2004-2005 Member, Faculty Recruitment Committee, Department of Biostatistics and Epidemiology, University of Pennsylvania

Meetings and Conferences Organizing Roles

2016-2017 Co-Chair, Division of Intramural Population Health Research 50th Anniversary Conference Program Committee, Eunice Kennedy Shriver National Institute of Child Health & Human Development
2013 Member, Applied Statistics Symposium Program Committee, International Chinese Statistical Association
2013 Member, Applied Statistics Symposium Local Committee, International Chinese Statistical Association
2012 Session chair, Statistics in Biomedical Research: Making and Translating New Discoveries, an NIH Biostatistics Symposium, Bethesda
2012 Session co-organizer, International Chinese Statistical Association Applied Symposium Applied Statistics Symposium, Boston
2011-2012 Member, Program Committee, Statistics in Biomedical Research: Making and Translating New Discoveries, an NIH Biostatistics Symposium
2011 Session organizer, International Chinese Statistical Association Applied Symposium Applied Statistics Symposium, New York
2010 Judge, NIH Fellows Award for Research Excellence
2008 Member, Program Committee, International Conference on Health Policy Statistics, Philadelphia
2007

Session organizer, the 15th International Conference of Forum for Interdisciplinary Mathematics on Interdisciplinary Mathematical & Statistical Techniques, Shanghai, China

2004 Session organizer, Joint Statistical Meeting, Toronto
2004 Session Chair, Eastern North American Region of International Biometric Society Spring Meeting, Pittsburgh
2003 Session Chair, Eastern North American Region of International Biometric Society Spring Mee2016-ting, Tampa

Society Memberships

1998- American Statistical Association
2000- International Biometric Society
2003- International Chinese Statistical Association

Research Support

Principal Investigator, Eunice Kennedy Shriver National Institute of Child Health and Human Development Intramural Funding

2009-2010 The Physician Reliability Study (PRS); #NO1DK63427; $327,965

Co-Investigator, Eunice Kennedy Shriver National Institute of Child Health and Human Development Intramural Funding

2008-2010 Longitudinal Investigation of Fertility and the Environment (PI: Buck Louis; $11,000,000)
2008-2010 Endometriosis: Natural History, Diagnosis and Outcomes (PI: Buck Louis; $5,300,000)
2011-2016 Folic Acid and Zinc Supplementation Randomized Trial (PI: Schisterman / Mumford; $12,800,000)
2015-2019 Impact of Diet, Exercise and Lifestyle on Fertility Study (PI: Mumford; $4,432,350)
2013-2018 B-WELL-Mom Study – Asthma and Pregnancy (PI: Mendola; $9,023,623)

Co-Investigator, University of Pennsylvania

2003-2007 The International Normalized Ratio Adherence and Genetics (IN-RANGE) Study, 20% effort (PI: Kimmel)
2004-2008 University of Pennsylvania Cancer Center Core Support Grant, 20% effort (PI: Glick)
2005-2006 Financial Incentives for Smoking Cessation, 5% effort (PI: Volpp)
2005-2008 National Children's Study Data Analysis Center, 10% effort (PI: Ellenberg)
2005-2008 Cognitive Decline in Chronic Renal Insufficiency, 10% effort (PI: Yaffe / Feldman)
2006-2008 Chronic Renal Insufficiency Cohort (CRIC) Study, 15% effort (PI: Feldman)
2006-2008 GWAS study in PENN-CATH cohort, 10% effort (PI: Reilly)
2006-2008 Implications of Cardiovascular Technology Diffusion Among Medicare Beneficiaries, 10% effort (PI: Groeneveld)

Honors & Awards

2012 NIH Merit Award, Eunice Kennedy Shriver National Institute of Child Health & Human Development. For successfully designing and completing the novel ENDO Study aimed at answering questions about environmental influences on endometriosis
2009 NIH Merit Award, Eunice Kennedy Shriver National Institute of Child Health & Human Development. For Ingenuity in Designing and Dedication in Completing the LIFE Study, Whose Aim is to Identify Environmental Reproductive Toxicants
2002 Young Investigator Award, Statistics in Epidemiology Section, American Statistical Association
1997 H. Fairfield Smith Award for excellence in applied statistics, University of Connecticut

Teaching

Graduate

2007 Applied Bayesian Data Analysis (BSTA 771), Department of Biostatistics and Epidemiology, University of Pennsylvania
2007 Statistical Methods in Epidemiological Research (BSTA 521), Department of Biostatistics and Epidemiology, University of Pennsylvania
2006 Applied Bayesian Data Analysis (BSTA 771), Department of Biostatistics and Epidemiology, University of Pennsylvania
2005 Bayesian Categorical Data Analysis (BSTA 999), Department of Biostatistics and Epidemiology, University of Pennsylvania

Undergraduate

2000 Introduction to Statistics (STAT 100), Department of Statistics, University of Connecticut
1997 Introduction to Statistics (STAT 100), Department of Statistics, University of Connecticut

Invited Talks and Seminars

  1. Modeling of couple exposure to pollutants and their association to time to pregnancy, Georgetown University, Washington DC, 2017
  2. Latent risk model for infertility, George Washington University, Washington DC, 2016
  3. A placement-valued based approach to correlated ROC curves subject to stochastic constraints, John Hopkins University, Baltimore, MD, 2015
  4. Estimating diagnostic accuracy of endometriosis without a gold standard: new sensitivity analysis approaches which address the problems with standard latent class models, International Biometric Conference, Florence, Italy, 2014
  5. Marginal approach to missing data in measurement agreement, George Mason University, VA, 2013
  6. Causal inference in analysis of pregnant related outcomes, John Hopkins University, Baltimore, MD, 2013
  7. Recent development in constrained Bayesian analysis, University of South Carolina, Columbia, SC, 2013
  8. A crossed random effects modeling approach for estimating diagnostic accuracy from ordinal ratings without a gold standard, International Chinese Statistical Association Applied Statistics Symposium, North Bethesda, MD, 2013
  9. A Bayesian approach to limit of detection, University of Maryland at Baltimore County, MD, 2012
  10. A Bayesian approach to limit of detection, International Chinese Statistical Association Applied Statistics Symposium, Boston, MA, 2012
  11. A Bayesian approach to limit of detection, George Washington University, Washington DC, 2012
  12. Latent class models for joint analysis of disease prevalence and high-dimensional chemical exposures, international toxicology of mixtures conference, Arlington, VA 2011
  13. Robustness in linear models with informative cluster size, International Chinese Statistical Association Applied Statistics Symposium, New York, NY, 2011
  14. Discussion of statistical methods in reproductive epidemiology, Joint Statistical Meeting, Washington DC, 2009
  15. More accurate copy number variation calls in family SNP genotyping data using Bayesian hidden Markov models and inheritance vectors, National Institute of Child Health and Human Development, Rockville, MD, 2009
  16. Copy number variation calls in family SNP genotyping data using Bayesian hidden Markov models and inheritance vectors, Thomas Jefferson University, Philadelphia, 2008
  17. More accurate copy number variation calls in family SNP genotyping data using Bayesian hidden Markov models and inheritance vectors, Fox Chase Cancer Center, Philadelphia, 2008
  18. More accurate copy number variation calls in family SNP genotyping data using Bayesian hidden Markov models and inheritance vectors, 57th American Society of Human Genetics Annual Meeting, San Diego, 2007
  19. Modeling developmental toxicity endpoints: a causal inference approach, University of Connecticut, CT, 2007
  20. Modeling developmental toxicity endpoints: a causal inference approach, Joint Meeting of Chinese Society of Probability and Statistics and Institute of Mathematical Sciences, Beijing, 2005
  21. Modeling developmental toxicity endpoints: a causal inference approach, University of Pittsburgh, PA, 2005
  22. Selecting factors predictive of heterogeneity in multivariate event time data, Eastern North American Region of International Biometric Society, Pittsburgh, PA, 2004
  23. Modeling truncated count data with endogeneity in health service research, Peking University, Beijing, 2004
  24. Random effects selection in linear mixed effects model, Rand Corporation, Santa Monica, CA, 2003
  25. Random effects selection in linear mixed effects model, University of Texas M.D. Andersen Cancer Center, Houston, TX, 2003
  26. Random effects selection in linear mixed effects model, University of Pennsylvania, Philadelphia, PA, 2003
  27. Random effects selection in linear mixed effects model, Vanderbilt University, Nashville, TN, 2003
  28. Random effects selection in linear mixed effects model, University of Iowa, Iowa City, IA, 2003
  29. Random effects selection in linear mixed effects model, Eastern North American Region of International Biometric Society, Tampa, FL, 2003
  30. A Bayesian approach for assessing heterogeneity in generalized linear models, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 2002
  31. A Bayesian approach for assessing heterogeneity in generalized linear models, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2002
  32. A Bayesian approach for assessing heterogeneity in generalized linear models, Statistical and Applied Mathematical Sciences Institute, Research Triangle Park, NC, 2002
  33. A skewed multinomial probit model for discrete choice data, University of Maryland, Baltimore, MD, 2001
  34. A skewed multinomial probit model for discrete choice data, North Carolina State University, Raleigh, NC, 2001
  35. A skewed multinomial probit model for discrete choice data, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 2001
  36. A skewed multinomial probit model for discrete choice data, Bayesian Application and Methods in Marketing Conference, Columbus, OH, 2000

Contributed Talks at Professional Meetings

  1. Estimation of ROC surfaces under stochastic and variability constraints, Eastern North American Region of International Biometric Society, Washington DC, 2017
  2. A Bayesian high dimensional latent risk model for fecundity, Joint Statistical Meetings, Chicago, IL, 2016
  3. A placement-valued based approach to correlated ROC curves subject to stochastic constraints, Eastern North American Region of International Biometric Society, Austin, TX, 2016
  4. Estimation of ROC surfaces under stochastic and variability constraints, Joint Statistical Meetings, Seattle, WA, 2015
  5. A rank-based ROC hierarchical model for correlated ROC curves, Eastern North American Region of International Biometric Society, Miami, FL, 2015
  6. Marginal analysis of measurement agreement among multiple raters with non-ignorable missing ratings, Eastern North American Region of International Biometric Society, Orlando, FL, 2013
  7. Bayesian order restricted inference of measurement agreement with an application to the Physician Reliability Study, Eastern North American Region of International Biometric Society, Washington DC, 2012
  8. Bi-directional mixed effects models, Eastern North American Region of International Biometric Society, New Orleans, LA 2010
  9. An integrated Bayesian hidden Markov model approach to CNVs incorporating pedigree information, ISBA 2010 World Meeting, Benidorm, Spain, 2010
  10. More accurate copy number variation calls in family SNP genotyping data using Bayesian hidden Markov models and inheritance vectors, Eastern North American Region of International Biometric Society, Arlington, VA 2008
  11. Detection of copy number variations from high-density SNP arrays: an integrated Bayesian hidden Markov model approach incorporating pedigree information, Joint Statistical Meetings, Denver, CO 2008
  12. Bayesian frailty selection in Cox models, Joint Statistical Meetings, Salt Lake City, UT 2007
  13. On estimating multinomial logit models with random effects, New England Statistics Symposium, Storrs, CT, 2001
  14. Parametric discrete choice models based on the scale mixtures of multivariate normal distributions, Joint Statistical Meeting, Indianapolis, IN, 2000
  15. A composite transition model for brand choice and purchase timing data, New England Statistics Symposium, Storrs, CT, 1999

Publications

Refereed Manuscripts (* Mentee first authored)

  1. Chen, Z and Kuo, L. A note on the estimation of the multinomial logit model with random effects. The American Statistician, 55(2):89-95, 2001. DOI: 10.1198/000313001750358545 External Web Site Policy
  2. Chen, Z and Kuo, L. Discrete choice models based on the scale mixtures of multivariate normal distributions. Sankhyā: The Indian Journal of Statistics, Series B, 64(2):192-213, 2002. Stable URL: http://www.jstor.org/stable/25053216 External Web Site Policy
  3. Chen, Z and Dunson, DB. Random effects selection in linear mixed models. Biometrics, 59(4):762-769, 2003. PMID: 14969453
  4. Dunson, DB, Chen, Z, and Harry, J. A Bayesian approach for joint modeling of cluster size and subunit-specific outcomes. Biometrics, 59(3):521-530, 2003. PMID: 14601753
  5. Daniels, JL, Longnecker, MP, Klebanoff, MA, Gray, KA, Brock, JW, Zhou, H, Chen, Z, and Needham, LL. Prenatal exposure to low-level polychlorinated biphenyls in relation to mental and motor development at 8 months. American Journal of Epidemiology, 157(6):485-492, 2003. PMID: 12631537
  6. Chen, Z and Dunson, DB. Bayesian estimation of survival functions under stochastic precedence. Lifetime Data Analysis, 10(2):159-173, 2004. PMID: 15293630
  7. Dunson, DB and Chen, Z. Selecting factors predictive of heterogeneity in multivariate event time data. Biometrics, 60(2):352-358, 2004. PMID: 15180660. DOI: 10.1111/j.0006-341X.2004.00179.x External Web Site Policy
  8. Kuo, L and Chen, Z. A state duration model for brand choice and inter-purchase time. Journal of Data Science, 2:125-147, 2004.
  9. O’Brien, PK, Kucharczuk, JC, Marshall, MB, Friedberg, JS, Chen, Z, Kaiser, LR, and Shrager, JB. Comparative study of subxiphoid versus video-thoracoscopic pericardial “window”. Annals of Thoracic Surgery, 80(6):2013-2019, 2005. PMID: 16305836. DOI: 10.1016/j.athoracsur.2005.05.059 External Web Site Policy
  10. Longnecker, MP, Klebanoff, MA, Dunson, DB, Guo, X, Chen, Z, Zhou, H, and Brock, JW. Maternal serum level of the DDT metabolite DDE in relation to fetal loss in previous pregnancies. Environmental Research, 97(2):127-133, 2005. PMID: 15533328. DOI: 10.1016/S0013-9351(03)00108-7 External Web Site Policy
  11. Hall, CB, Verghese, J, Sliwinski, M, Chen, Z, Katz, M, Derby, C, and Lipton, RB. Dementia incidence may increase more slowly after age 90: results from the Bronx Aging Study. Neurology, 65(6):882-886, 2005. PMID: 16186528. DOI: 10.1212/01.wnl.0000176053.98907.3f External Web Site Policy
  12. Shrager, JB, Nathan, D, Brinster, CJ, Yousuf, O, Spence, A, Chen, Z, and Kaiser, LR. Outcomes after 151 extended transcervical thymectomies for myasthenia gravis. Annals of Thoracic Surgery, 82(5):1863-1869, 2006. PMID: 17062262. DOI: 10.1016/j.athoracsur.2006.05.110 External Web Site Policy
  13. Elliott, MR, Joffe, MM, and Chen, Z. A potential outcomes approach to developmental toxicity analyses. Biometrics, 62(2):352-360, 2006. PMID: 16918899. DOI: 10.1111/j.1541-0420.2005.00506.x External Web Site Policy
  14. Parker, CS, Chen, Z, Price, M, Gross, R, Metlay, JP, Christie, JD, Brensinger, CM, Newcomb, CW, Samaha, FF, and Kimmel, SE. Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: Results from the IN-RANGE study. Journal of General Internal Medicine, 22(9):1254-1259, 2007. PMID: 17587092. PMCID: PMC2219760. DOI: 10.1007/s11606-007-0233-1 External Web Site Policy
  15. Kealey, C, Chen, Z, Christie, J, Thorn, CF, Whitehead, AS, Price, M, Samaha, FF, and Kimmel, SE. Warfarin and cytochrome P450 2C9 genotype: Possible ethnic variation in warfarin sensitivity. Pharmacogenomics, 8(3):217-225, 2007. PMID: 17324110. DOI: 10.2217/14622416.8.3.217 External Web Site Policy
  16. Schelleman, H, Chen, Z, Kealey, C, Whitehead, AS, Christie, J, Price, M, Brensinger, CM, Newcomb, CW, Thorn, CF, Samaha, FF, and Kimmel, SE. Warfarin response and vitamin K epoxide reductase complex 1 in African Americans and Caucasians. Clinical Pharmacology & Therapeutics, 81(5):742-747, 2007. PMID: 17329985. DOI: 10.1038/sj.clpt.6100144 External Web Site Policy
  17. Kimmel, SE, Chen, Z, Price, M, Parker, CS, Metlay, JP, Christie, JD, Brensinger, CM, Newcomb, CW, Samaha, FF, and Gross, R. The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study. Archives of Internal Medicine, 167(3):229-235, 2007. PMID: 17296877. DOI: 10.1001/archinte.167.3.229 External Web Site Policy
  18. Friscia, ME, Zhu, J, Kolff, JW, Chen, Z, Kaiser, LR, Deutschman, CS, and Shrager, JB. Cytokine response is lower after lung volume reduction through bilateral thoracoscopy versus sternotomy. Annals of Thoracic Surgery, 83(1):252-256, 2007. PMID: 17184673. DOI: 10.1016/j.athoracsur.2006.08.012 External Web Site Policy
  19. Groeneveld, PW, Kruse, GB, Chen, Z, and Asch, DA. Variation in cardiac procedure use and racial disparity among Veterans Affairs Hospitals. American Heart Journal, 153(2):320-327, 2007. PMID: 17239696. DOI: 10.1016/j.ahj.2006.10.032 External Web Site Policy
  20. Polsky, D, Lave, J, Klusaritz, H, Jha, A, Pauly, MV, Cen, L, Xie, H, Stone, R, Chen, Z, and Volpp, K. Is lower 30-day mortality posthospital admission among blacks unique to the Veterans Affairs health care system? Medical Care, 45(11):1083-1089, 2007. DOI: PMID: 18049349. DOI: 10.1097/MLR.0b013e3180ca960e External Web Site Policy
  21. Guzzo, TJ, Levin, BM, Lee, R, Guo, M, Chen, Z, Whittington, R, Tomaszewski, J, and Malkowicz, SB. Relationship of biochemical outcome to percentage of positive biopsies in men with clinically localized prostate cancer treated with permanent interstitial brachytherapy. Urology, 71(4):723-727, 2008. PMID: 18387401. DOI: 10.1016/j.urology.2007.09.027 External Web Site Policy
  22. Canter, D, Guzzo, TJ, Resnick, MJ, Brucker, B, Vira, M, Chen, Z, Tomaszewski, J, VanArsdalen, K, Wein, AJ, and Malkowicz, SB. Hydronephrosis is an independent predictor of poor clinical outcome in patients treated for muscle-invasive transitional cell carcinoma with radical cystectomy. Urology, 72(2):379-383, 2008. PMID: 18514771. DOI: 10.1016/j.urology.2008.03.053 External Web Site Policy
  23. Meropol, SB, Chan, KA, Chen, Z, Finkelstein, JA, Hennessy, S, Lautenbach, E, Platt, R, Schech, SD, Shatin, D, and Metlay, JP. Adverse events associated with prolonged antibiotic use. Pharmacoepidemiology and Drug Safety, 17(5):523-532, 2008. PMID: 18215001. PMCID: PMC4269235. DOI: 10.1002/pds.1547 External Web Site Policy
  24. Polsky, D, Jha, AK, Lave, J, Pauly, MV, Cen, L, Klusaritz, H, Chen, Z, and Volpp, KG. Short- and long-term mortality after an acute illness for elderly whites and blacks. Health Services Research, 43(4):1388-1402, 2008. PMID: 18355259. PMCID: PMC2517279. DOI: 10.1111/j.1475-6773.2008.00837.x External Web Site Policy
  25. Hubbard, RD, Chen, Z, and Winkelstein, BA. Transient cervical nerve root compression modulates pain: Load thresholds for allodynia and sustained changes in spinal neuropeptide expression. Journal of Biomechanics, 41(3):677-685, 2008. PMID: 17976629. PMCID: PMC2270480. DOI: 10.1016/j.jbiomech.2007.09.026 External Web Site Policy
  26. Lee, I, Thompson, S, Lautenbach, E, Gasink, LB, Watson, B, Fishman, NO, Chen, Z, Linkin, DR. Effect of accessibility of influenza vaccination on the rate of childcare staff vaccination. Infection Control and Hospital Epidemiology, 29(5):465-467, 2008. PMID: 18419374. PMCID: PMC3697428. DOI: 10.1086/587970 External Web Site Policy
  27. Casarett, D, Pickard, A, Bailey, FA, Ritchie, C, Furman, C, Rosenfeld, K, Shreve, S, Chen, Z, and Shea, JA. Do palliative consultations improve patient outcomes? Journal of the American Geriatrics Society, 56(4):593-599, 2008. PMID: 18205757. DOI: 10.1111/j.1532-5415.2007.01610.x External Web Site Policy
  28. Wang, K, Chen, Z, Tadesse, MG, Glessner, J, Grant, SF, Hakonarson, H, Bucan, M, and Li, M. Modeling genetic inheritance of copy number variations. Nucleic Acids Research, 36(21):e138, 2008. PMID: 18832372. PMCID: PMC2588508. DOI: 10.1093/nar/gkn641 External Web Site Policy
  29. Kimmel, SE, Christie, J, Kealey, C, Chen, Z, Price, M, Thorn, CF, Brensinger, CM, Newcomb, CW, and Whitehead, AS. Apolipoprotein E genotype and warfarin dosing among Caucasians and African Americans. Pharmacogenomics Journal, 8(1):53-60, 2008. PMID: 17325732. DOI: 10.1038/sj.tpj.6500445 External Web Site Policy
  30. Schelleman, H, Chen, J, Chen, Z, Christie, J, Newcomb, CW, Brensinger, CM, Price, M, Whitehead, AS, Kealey, C, Thorn, CF, Samaha, FF, and Kimmel, SE. Dosing algorithms to predict warfarin maintenance dose in Caucasians and African Americans. Clinical Pharmacology & Therapeutics, 84(3):332-339, 2008. PMID: 18596683. PMCID: PMC2538606. DOI: 10.1038/clpt.2008.101 External Web Site Policy
  31. Meropol, SB, Chen, Z, and Metlay, JP. Reduced antibiotic prescribing for acute respiratory infections in adults and children. British Journal of General Practice, 59(567):e321-8, 2009. PMID: 19843412. PMCID: PMC2751936. DOI: 10.3399/bjgp09X472610 External Web Site Policy
  32. Platt, AB, Field, SH, Asch, DA, Chen, Z, Patel, NP, Gupta, R, Roche, DF, Gurubhagavatula, I, Christie, JD, and Kuna, ST. Neighborhood of residence is associated with daily adherence to CPAP therapy. Sleep, 32(6):799-806, 2009. PMID: 19544757. PMCID: PMC2690568
  33. Myocardial Infarction Genetics Consortium, Kathiresan, S, Voight, BF, Purcell, S, Musunuru, K, Ardissino, D, Mannucci, PM, Anand, S, Engert, JC, Samani, NJ, Schunkert, H, Erdmann, J, Reilly, MP, Rader, DJ, Morgan, T, Spertus, JA, Stoll, M, Girelli, D, McKeown, PP, Patterson, CC, Siscovick, DS, O’Donnell, CJ, Elosua, R, Peltonen, L, Salomaa, V, Schwartz, SM, Melander, O, Altshuler, D, Merlini, PA, Berzuini, C, Bernardinelli, L, Peyvandi, F, Tubaro, M, Celli, P, Ferrario, M, Fetiveau, R, Marziliano, N, Casari, G, Galli, M, Ribichini, F, Rossi, M, Bernardi, F, Zonzin, P, Piazza, A, Mannucci, PM, Schwartz, SM, Siscovick, DS, Yee, J, Friedlander, Y, Elosua R, Marrugat, J, Lucas, G, Subirana, I, Sala, J, Ramos, R, Kathiresan, S, Meigs, JB, Williams, G, Nathan, DM, MacRae, CA, O’Donnell, CJ, Salomaa, V, Havulinna, AS, Peltonen, L, Melander, O, Berglund, G, Voight, BF, Hirschhorn, JN, Asselta R, Duga S, Spreafico M, Daly, MJ, Parcell, S, Nemesh, J, Korn, JM, McCarroll, SA, Schwartz, SM, Yee, J, Lucas, G, Surti, A, Guiducci, C, Gianniny, L, Mirel, D, Parkin, M, Burtt, N, Gabriel, SB, Samani, NJ, Thompson, JR, Braund, PS, Wright, BJ, Balmforth, AJ, Ball, SG, and Hall, A; Wellcome Trust Case Control Consortium, Schunkert, H, Erdmann J, Linsel-Nitschke, P, Lieb, W, Ziegler, A, König, IR, Hengstenberg, C, Fisher, M, Stark, K, Grosshennig, A, Preuss, M, Wichmann, HE, Schreiber, S, Samani, NJ, Erdmann, J, Ouwehand, W, Deloukas, P, Scholz, M, Cambien, F, Reilly, MP, Li, M, Chen, Z, Wilensky, R, Matthai, W, Qasim, A, Hakonarson, HH, Devaney, J, Burnett, MS, Pichard, AD, Kent, KM, Satler, L, Lindsey JM, Waksman, R, Knouff CW, Wilensky R, Matthai W, Qasim A, Devaney J, Burnett MS, Pichard AD, Kent KM, Satler L, Waterworth DM, Walker MC, Mooser V, Epstein, SE, Rader DJ, Scheffold, T, Berger, K, Huge, A, Girelli D, Martinelli, N, Olivieri, O, Corrocher, R, Morgan T, Spertus JA, McKeown P, Patterson CC, Erdmann E, Hólm, H, Thorleifsson, G, Thorsteinsdottir, U, Stefansson, K, Engert JC, Do R, Xie C, Anand S, Kathiresan S, Ardissino D, Mannucci PM, Siscovick D, O’Donnell CJ, Samani NJ, Melander O, Elosua R, Peltonen L, Salomaa V, Schwartz SM, and Altshuler D. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nature Genetics, 41(3):334-341, 2009. PMID: 19198609. PMCID: PMC2681011. DOI: 10.1038/ng.327 External Web Site Policy
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  94. Mumford, SL, Kim, S, Chen, Z, Boyd Barr, D, and Buck Louis, GM. Urinary Phytoestrogens Are Associated with Subtle Indicators of Semen Quality among Male Partners of Couples Desiring Pregnancy. Journal of Nutrition, 145(11):2535-2541, 2015. PMID: 26423741. PMCID: PMC4620723. DOI: 10.3945/jn.115.214973 External Web Site Policy
  95. Bloom, MS, Whitcomb, BW, Chen, Z, Ye, A, Kannan, K, and Buck Louis, GM. Associations between urinary phthalate concentrations and semen quality parameters in a general population. Human Reproduction, 30(11):2645-2657, 2015. PMID: 26350610. PMCID: PMC4605371. DOI: 10.1093/humrep/dev219 External Web Site Policy
  96. Wallace, ME, Mendola, P, Chen, Z, Hwang, BS, and Grantz, KL. Preterm birth in the context of increasing income inequality. Maternal & Child Health Journal, 20(1):164-171, 2015. PMID: 26450504. DOI: 10.1007/s10995-015-1816-9 External Web Site Policy
  97. Männistö, T, Mendola, P, Kiely, M, O’Loughlin, J, Werder, E, Chen, Z, Ehrenthal, DB, Grantz, KL. Maternal psychiatric disorders and risk of preterm. Annals of Epidemiology, 26(1):14-20, 2016. PMID: 26586549. PMCID: PMC4688227. DOI: 10.1016/j.annepidem.2015.09.009 External Web Site Policy
  98. Buck Louis, GM, Barr, DB, Kannan, K, Chen, Z, Kim, S, and Sundaram, R. Paternal Exposures to Environmental Chemicals and Time-to-Pregnancy: Overview of Results from the LIFE Study. Andrology. 4(4):639-647, 2016. PMID: 27061873. PMCID: PMC4961554. DOI: 10.1111/andr.12171 External Web Site Policy
  99. Sapra, KJ, Eisenberg, ML, Kim, S, Chen, Z, and Buck Louis, GM. Choice of underwear and male fecundity in a preconception cohort of couples. Andrology, 4(3):500-508, 2016. PMID: 26939021. DOI: 10.1111/andr.12163 External Web Site Policy
  100. Schliep, KC, Mumford, SL, Johnstone, EB, Peterson, CM, Sharp, HT, Stanford, JB, Chen, Z, Backonja, U, Wallace, ME, and Buck Louis, GM. Sexual and physical abuse and gynecologic disorders. Human Reproduction, 31(8):1904-1912, 2016. PMID: 27334336. PMCID: PMC4974667. DOI: 10.1093/humrep/dew153 External Web Site Policy
  101. Kim, SS, Zhu, Y, Grantz, KL, Hinkle, SN, Chen, Z, Wallace, ME, Smarr, MM, Epps, NM, and Mendola, P. Obstetric and neonatal risks among obese women without chronic disease. Obesity, 128(1):104-112, 2016. PMID: 27275800. PMCID: PMC4917420. DOI: 10.1097/AOG.0000000000001465 External Web Site Policy
  102. Buck Louis GM, Backonja U, Schliep KC, Sun, L, Peterson CM, and Chen, Z. Women’s Reproductive History Prior to the Diagnosis of Incident Endometriosis. Journal of Women’s Health, 25(10):1021-1029, 2016. PMID: 27379997. PMCID: PMC5111831. DOI: 10.1089/jwh.2015.5712 External Web Site Policy
  103. Fan, R, Chiu, CY, Jung, J, Weeks, DE, Wilson, AF, Bailey-Wilson, JE, Amos, CI, Chen, Z, Mills, JL and Xiong, M. A comparison study of fixed and mixed effect models for gene level association studies of complex traits. Genetic Epidemiology, 40(8):702-721, 2016. PMID: 27374056. DOI: 10.1002/gepi.21984
  104. Bae, J, Kim, S, Chen, Z, Eisenberg, ML, and Buck Louis, GM. Human semen quality and the secondary sex ratio. Asian Journal of Andrology, 19(3):374-381, 2017. PMID: 26975484. PMCID: PMC5427797. DOI: 10.4103/1008-682X.173445 External Web Site Policy
  105. Wallace, ME, Mendola, P, Kim, SS, Epps, N, Chen, Z, Smarr, M, Hinkle, SN, Zhu, Y, and Grantz, KL. Racial/ethnic differences in preterm perinatal outcomes. The American Journal of Obstetrics and Gynecology, 216(3):306.e1-306.e12, 2017. PMID: 27865977. DOI: 10.1016/j.ajog.2016.11.1026 External Web Site Policy
  106. Schliep KC, Chen Z, Stanford JB, Xie Y, Mumford SL, Hammoud AO, Boiman Johnstone E, Dorais JK, Varner MW, Buck Louis GM, and Peterson CM. Endometriosis diagnosis and staging by operating surgeon and expert review using multiple diagnostic tools: an inter-rater agreement study. British Journal of Obstetrics & Gynaecology, 124(2):220-229, 2017. PMID: 26435386. PMCID: PMC4821828. DOI: 10.1111/1471-0528.13711 External Web Site Policy
  107. Whitcomb, BW, Bloom, MS, Kim, S, Chen, Z, and Buck Louis, GM. Male birthweight, semen quality and birth outcomes. Human Reproduction, 32(3):505-513, 2017. PMID: 28104697. PMCID: PMC5400075. DOI: 10.1093/humrep/dew345 External Web Site Policy
  108. Radin RG, Sjaarda LA, Perkins NJ, Silver RM, Chen Z, Lesher LL, Galai N, Wactawski-Wende J, Mumford SL, and Schisterman EF. Low-dose aspirin and sporadic anovulation in the EAGeR randomized trial. Journal of Clinical Endocrinology and Metabolism, 102(1):86-92, 2017. PMID: 27754808. PMCID: PMC5413097. DOI: 10.1210/jc.2016-2095 External Web Site Policy
  109. Backonja, U, Hediger, M, Chen, Z, Lauver, DR, Sun, L, Peterson, M, and Buck Louis, GM. Beyond body mass index: Using anthropometric measures and body composition indicators to assess odds of an endometriosis diagnosis. Journal of Women’s Health, 2017 May 24. PMID: 28537460. DOI: 10.1089/jwh.2016.6128 External Web Site Policy
  110. Kawakita, T, Bowers, K, Hazrati, S, Zhang, C, Grewal, J, Chen, Z, Sun, L, and Grantz, KL. Increased neonatal respiratory morbidity associated with gestational and pre-gestational diabetes: a retrospective study. American Journal of Perinatology, 2017 Jul 24. PMID: 28738436. DOI: 10.1055/s-0037-1604414 External Web Site Policy
  111. Smarr, SM, Kannan, K, Chen, Z, Kim, S, and Buck Louis, GM. Male urinary paracetamol and semen quality. Andrology, in press.
  112. Eisenberg, M, Sapra, K, Kim, S, Chen, Z, and Buck Louis, GM. Semen quality and pregnancy loss in a contemporary cohort of couples recruited before conception: Data from the LIFE Study. Fertility & Sterility, in press.

Manuscripts under Review (* Mentee first authored papers, ** Co-first authored)

  1. **Kim, S, Chen, Z, Perkins, N, Schisterman, E, and Buck Louis, GM. A model-based approach to limit of detection in studying persistent environmental chemical exposures and human fecundity. Bayesian Analysis, under revision.
  2. *Hwang, B, Chen, Z, Buck Louis, GM, and Albert, PS. A Bayesian high-dimensional couple-based latent risk model with an application to infertility. Biometrics, under revision.
  3. Chen, Z and Hwang, B. Modeling correlated ROC surfaces with stochastic constraints. Biostatistics, under revision.
  4. Chen, Z, Kim, S, and Hwang, B. A correlated Bayesian rank likelihood approach to multiple ROC curves for endometriosis. Statistics in Medicine, submitted.
  5. *Zhang, W, Chen, Z, Liu, A, and Buck Louis, GM. A weighted kernel machine regression approach to environmental pollutants and infertility. Journal of the American Statistical Association, submitted.
  6. Nobles, C, Schisterman, E, Ha, S, Kim, K, Mumford, S, Buck Louis, GM, Chen, Z, Liu, D, Sherman, S, and Mendola, P. Ambient air pollution and semen quality. Environmental Heath Perspectives, submitted.
  7. Kissell KA, Schisterman EF, Weck J, Danaher M, Hwang B, Chen Z, Wactawski-Wende J, Perkins NJ, Sjaarda L, Zarek S, and Mumford SL. Pregnancy history and adverse pregnancy outcomes and subsequent maternal serum anti-Müllerian hormone levels. Journal of Clinical Endocrinology & Metabolism, submitted.