James Louis Mills, M.D., M.S.

August 2017

Current Position

Senior Biomedical Research Service Scientist
Senior Investigator
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health
2000-present

Address

Epidemiology Branch
Division of Intramural Population Health Research
6100 Executive Boulevard, Room 7B03
Bethesda, Maryland 20892
Voice: (301) 496-5394
FAX: (301) 402-2084
E-mail: jamesmills@nih.gov

Education

University of Pennsylvania: 1965-1969
Degree: Bachelor of Arts, with Distinction, 1969
Major: History - Pre Med

New York Medical College: 1969-1973
Degree: Doctor of Medicine, 1973

University of Pennsylvania: 1978-1979
Degree: Master of Science, 1979
Course: Epidemiology

Academic & Research Experience

Chief, Pediatric Epidemiology Section
Epidemiology Branch
Division of Epidemiology, Statistics, and Prevention Research
National Institute of Child Health and Human Development
1990-2006 (sections eliminated in restructuring, 2006)

Senior Investigator (Research Medical Officer, GS-13, GS-14 and GS-15)
National Institute of Child Health and Human Development
National Institutes of Health
1982-1999

Medical Staff Fellow
National Institute of Child Health and Human Development
National Institutes of Health
1979-1982

Post Graduate Training and Fellowship Appointments

Pediatric Resident, The New York Hospital
Cornell University Medical Center, 1973-1975

Fellow in Ambulatory Pediatrics, Children's
Hospital of Philadelphia, 1975-1976

Fellow in Endocrinology, Children's Hospital of Philadelphia, 1976-1979

Robert Wood Johnson Clinical Scholar
University of Pennsylvania, 1976-1979

Faculty Appointments

Fellow: Department of Pediatrics
Cornell University School of Medicine, 1974-1975

Post-Doctoral Fellow: Department of Research Medicine
University of Pennsylvania, 1976-1979

Attending Pediatric Endocrinologist: Clinical Center
National Institutes of Health 1979-1995

Attending Pediatrician: Clinical Center
National Institutes of Health 1981-1984

Lecturer: Department of Epidemiology
The Johns Hopkins University, 1982-1985

Associate: Department of Epidemiology
The Johns Hopkins University, 1985-present

Consultant Pediatric Endocrinologist: National Naval Medical Center 1985-2005

Medical Certification

Diplomate: National Board of Medical Examiners, 1974
Specialty Certification: American Board of Pediatrics, 1978
Sub-Specialty Certification: American Board of Pediatrics, Pediatric
Endocrinology Sub-Board, 1980

Licensure: New York, Pennsylvania

Professional Societies

American Epidemiological Society
American Pediatric Society
Pediatric Endocrine Society
Society for Pediatric Research
American College of Epidemiology
Teratology Society

Other Professional Training and Experience

Research Assistant, Laboratory of Human Genetics, New York Medical College, 1970-1971

Fellow in Tropical Medicine, International Center for Medical Research and Training, National Institutes of Health, San Jose, Costa Rica, 1972

Graduate Student in Health Care Administration, The Wharton School, University of Pennsylvania, 1976-1977

Pediatrician, Medical Associates, Children's Hospital of Philadelphia, 1977-1979

Consultant Endocrinologist, Ortho Pharmaceutical Corporation and Paul D. Stolley, M.D. Study of Estrogen Effects in Oral Contraceptive Workers, 1978-1979

Scientific Review Service (since 2000)

Journal Reviewer

New England Journal of Medicine (frequent reviewer)
JAMA
The Lancet
American Journal of Epidemiology
American Journal of Obstetrics and Gynecology
American Journal of Medical Genetics
Birth Defects Research-A
American Journal of Clinical Nutrition
Pediatrics
Pediatric and Perinatal Epidemiology
Others- this is not something I systematically record

Extramural Grant Review

Reviewer, Center For Inherited Disease Research, Gene Environment and Health Initiative Study, Technical Advisory Group, Bethesda, MD, October, 2007.

March of Dimes Research Advisory Committee A. Grant reviewer. February 2013.

March of Dimes Gene Discovery and Translational Grants Advisory Committee. Grant reviewer. February 2014.

March of Dimes Gene Discovery and Translational Grants Advisory Committee. Grant reviewer. February 2015.

Planning Committees – Workshops, Annual Meetings, Training

Symposium Chair and Organizer, Public Affairs Committee Symposium – Birth Defects and Other Adverse Pregnancy Outcomes Due to Obesity. Teratology Society, Vancouver, BC. June 2004.

Invited Speaker, Congenital Malformations. ART Children's Health: A Systematic Review. Workshop. American Society for Reproductive Medicine. Philadelphia, PA. October 2004.

Planning Committee, Teratology Society Annual Meeting, Monterey, CA. June 2008.

Planning Committee, Teratology Society Annual Meeting, Rio Mar, PR, June 2009

Planning Committee, NHANES Monitoring of Biomarkers of Folate and Vitamin B12 Status, 2009-2010

Organizer, Symposium: Vitamin B12 Deficiency and Neural Tube Defects. Teratology Society, Louisville, KY, June 2010.

Committees, Advisory Boards and Other Professional Services

Member, Second Structural Birth Defects Meeting, NICHD, Bethesda, December 2002.

Invited Expert, US Food and Drug Administration Pregnancy Labeling Subcommittee Meeting on Pregnancy Registries, Rockville, MD, February 2000

Participant/ Invited Speaker, Advisory Committee for Reproductive Health Drugs, Food and Drug Administration- Adding folic acid to oral contraceptives, December, 2003.

Advisor, US Food and Drug Administration. Division of Reproductive and Urologic Products. Silver Spring, MD, March, 2006.

Deputy Director for Intramural Research Representative, BSC review, Radiation Oncology Branch, NCI 2010

Public Affairs Committee. Teratology Society 2010-2013

NICHD Member and Executive Secretary. Data Safety Monitoring Board, CHEF Study. 2010-2014

Expert Reviewer. Technical Assistance Package—CDC to FDA. Corn Masa Flour Fortification.

Judge for the Marcy Speer Pre and Post Doctoral Research Awards. 7th International Conference on Neural Tube Defects, Nov. 2011.

Membership Committee. Teratology Society 2012-2014.

Biomarkers of Nutrition for Development (BOND) Folate Expert Panel Member. 2012-2014.

March of Dimes Consultant. Stillbirths 37 to 39 Weeks. December 2012.

Teratology Society. Mentor “Ambassador Program”. June 2014

Presidential Nominating Committee. American Epidemiological Society. March 2015

Expert Committee Member, Identifying Research Needs for Assessing Safe use of High Intakes of Folic Acid. National Toxicology Program/Office of Dietary Supplements. May 2015.

Scholarship Oversight Committee, Pediatric Endocrinology Fellowship Program, NICHD, NIH. 2014-present

Vaccines and Medications in Pregnancy Surveillance Systems, American Academy of Allergy, Asthma and Immunology, Advisory Committee Member, 2010-present

Science Committee, Teratology Society 2015- present

Invited Keynotes, Talks and Seminars

Invited Speaker, Slone Memorial Lecture, Slone Epidemiology Unit, Boston University, Boston, MA. April 2000

Faculty Member, Harvard Medical School Continuing Education Course on Human Teratogens, Boston, MA. April 2000.

Invited Speaker, Medical Grand Rounds, University of Pittsburgh, Pittsburgh, PA. Sept. 2000.

Invited Speaker, Plenary Session, Congress of Genetics and Molecular Medicine of Mexico, Monterrey, Mexico, Oct. 2000.

Expert Panel Member, Expert Panel on Periconceptional Folic Acid Use to Prevent Congenital Malformations, Budapest, Hungary. April 2001. Invited Speaker, Slone Memorial Lecture, Slone Epidemiology Unit, Boston University, Boston, MA. April 2000

Faculty Member, Harvard Medical School Continuing Education Course on Human Teratogens, Boston, MA. April 2000.

Invited Speaker, Medical Grand Rounds, University of Pittsburgh, Pittsburgh, PA. Sept. 2000.

Invited Speaker, Plenary Session, Congress of Genetics and Molecular Medicine of Mexico, Monterrey, Mexico, Oct. 2000.

Expert Panel Member, Expert Panel on Periconceptional Folic Acid Use to Prevent Congenital Malformations, Budapest, Hungary. April 2001.

Plenary Session Speaker, Charting the Course, Birth Defects, Developmental Disabilities, and Disability and Health. CDC, Atlanta, September, 2002.

Guest speaker, Clinical Nutrition Research Center, University of Alabama, Birmingham, November,2002.

Invited Speaker, Folic Acid-Beyond the Prevention of Neural Tube Defects. American College of Preventive Medicine, Orlando, FL. February 2004.

Invited Speaker, Current Topics in Neonatal/Infant Nutrition and Metabolism V. Methionine, Methylation and Epigenetics. Houston, TX. January 2005.

Invited Speaker, The Intrauterine Environment: Long-term Consequences of Obesity and Metabolic Disease Conference. Maternal Obesity and Birth Defects. Bethesda, MD. September, 2005.

Invited Speaker, Folic Acid and Neural Tube Defects. Pediatric Neurology Grand Rounds, Johns Hopkins School of Medicine, Baltimore, MD, October, 2006.

Invited Speaker, Careers in Washington, D.C.- Medical Research. University of Pennsylvania, Philadelphia, PA, February, 2007.

Invited Speaker, Neural Tube Defects and Folic Acid: The Science and The Controversy, Benjamin Franklin Scholars Program, University of Pennsylvania, Philadelphia, PA, February, 2007.

Invited Speaker, Food Fortification with Folic Acid: Effects and Side Effects. Organization of Teratology Information Specialists/Teratology Society Joint Meeting. Monterey, CA, June 2008.

Invited Speaker, Maternal Obesity and Congenital Heart Defects. Coordinating Committee, NICHD National Child and Maternal Health Education Program, Bethesda, MD. Jan. 2012

Invited Keynote Speaker and Session Chair, 9th International Conference on Homocysteine and One-carbon Metabolism, Dublin, Ireland September 2013.

Invited Speaker, Special Seminar. Wadsworth Center, New York State Department of Health. Folic Acid, Birth Defects and Food Fortification: Why is this a Problem? Albany, NY September 2016

Invited Workshops and Panel Discussions

Workshop Member, WHO Conference on International Collaborative Studies on the Prevention of Cranio-facial Abnormalities, Park City, Utah. May 2001.

Session Chair, NIH Structural Birth Defects Investigators Meeting, Bethesda, Maryland. July 2001.

Advisor, Centers for Disease Control and Prevention Neural Tube Defects-Folic Acid Intake Meeting (Evaluation of Data from NBDPS), Atlanta, GA, August, 2007.

Session Chair, Teratology Society Annual Meeting. Monterey, CA, June 2008.

Invitee, Challenges and Opportunities in Using Newborn Screening Samples for Translational Research: A Workshop. Institute of Medicine Roundtable on Translating Genomic-Based Research for Health, Washington, DC, May 2010.

Participant, Optimizing Folic Acid/Folate Awareness and Intake in High-Risk Women Roundtable. March of Dimes, Bayer Health Care Pharmaceuticals, Washington, DC, June 2010.

Invited Participant, Birth Defect Gene Research Conference (CDC), Washington, DC 2010

Invited Panel Member: NHANES Monitoring of Biomarkers of Folate and Vitamin B12 Status, 2010.

Faculty Member, Harvard Medical School Continuing Education Course on Human Teratogens, Boston, MA. April 2011.

Speaker, Mary Frances Picciano Dietary Supplements Research Practicum. Folate and Folic Acid. NIH. Folate and Folic Acid. June 2011.

Speaker, Mary Frances Picciano Dietary Supplements Research Practicum. NIH. Folate and Folic Acid. June 2012.

Faculty Member, Harvard Medical School Continuing Education Course on Human Teratogens, Boston, MA. April 2013.

Speaker, Mary Frances Picciano Dietary Supplements Research Practicum. NIH. Folate and Folic Acid. June 2013.

Speaker, Mary Frances Picciano Dietary Supplements Research Practicum. NIH. Folate and Folic Acid. June 2014.

Presentations at Scientific Meetings (as presenter)

Speaker and Panel Member, Consensus Conference on the Safe and Optimal Use of Isotretinoin, American Academy of Dermatology, New Orleans, Louisiana. February, 2002.

Speaker, Long-term Mortality in the U.S. Cohort of Pituitary Growth Hormone Recipients. American Epidemiological Society. New York, NY, March 2002.

Invited Speaker, Assisted Reproduction Technology and Reproductive Problems: What are the facts and Issues? Teratology Society, Phila. Pa. June 2003.

Invited Discussant, Selected Gene Polymorphisms of Possible Vascular Impact, and Their Interaction with Maternal Smoking, As Risk Factors for Gastroschisis. Teratology Society. St. Pete Beach, FL. June 2005.

Speaker, Maternal Obesity and Congenital Heart Defects. American Epidemiological Society, Baltimore, MD, March 2010.

Speaker, Vitamin B12 Deficiency and Neural Tube Defects: Is There a Causal Relationship? Teratology Society, Louisville, KY, June 2010.

Invited Speaker, NIAAA Collaborative Initiative on FASD. Feb. 2011.

Speaker, American Epidemiological Society. Do high blood folate levels exacerbate the metabolic abnormalities in people with low vitamin B12 levels? March 2011

Platform presentation, Free and total choline levels during pregnancy and neural tube defects. 7th International Conference on Neural Tube Defects, Nov. 2011.

Speaker, American Epidemiological Society. Choline: An “essential nutrient”, but is it essential to prevent neural tube defects? March 2012

Speaker, American Epidemiological Society. Food fortification produces unmetabolized folic acid in serum. March 2013.

Speaker, American Epidemiological Society. Obesity and Congenital Heart Defects, March 2014

Awards and Honors

General Honors Program, University of Pennsylvania, 1965
Graduation with Distinction in History, University of Pennsylvania, 1969
National Institutes of Health Student Fellowship for the Study of Tropical Medicine, 1972
Robert Wood Johnson Clinical Scholar, 1976
Fellow, Leonard Davis Institute, 1978
Elected to Society for Pediatric Research, 1984
Elected-Fellow, American College of Epidemiology, 1987
Selected for American Men and Women of Science, 1988
NIH Director's Award (NIH's Highest Award) for Birth Defects Research, 1989
NIH Special Act or Service Award for Research on Neural Tube Defects, 1990
Elected to American Pediatric Society, 1991
Elected to American Epidemiological Society, 1991
U.S. Public Health Service Special Recognition Award for Risks and Benefits of Fluoride Report, 1992.
Selected Speaker for University of Pennsylvania Distinguished Alumni-Faculty Lecture, 1994
Invited Speaker, Congressional Biomedical Research Caucus, 1995
All-Time Top NICHD Accomplishments@ Two projects among the 36 most important research achievements (intramural and extramural) in NICHD history, 1998
Richard K. Miller Lecturer, University of Rochester, 1999
Slone Memorial Lecturer, Boston University, 2000
NIH Director's Award for Research on Folate Metabolism and Birth Defects, 2000
Author of one of four Papers Selected As “Classic Papers” from 50 years of publications in the journal of the Teratology Society 2010
Centers for Disease Control and Prevention. Special Act or Service Award. “In recognition of your contribution to the health of children by providing scientific expertise to the assessment of the safety of folic acid” 2011.

Patent

Materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways. Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTBFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications. US7879551 External Web Site Policy

Mentoring

NIH Summer Interns

Laura Kresch, epidemiology graduate student
Isabelle Von Kohorn, medical student
Homa Khorrami, medical student
Irene Woo, medical student
Joshua Cornman-Homonoff, medical student

NIH IRTAs

Lucinda England, MD, MPH
Caroline Signore, MD, MPH
Elizabeth Flanigan, MD, MPH
Tonia Carter, PhD
Devon Kuehn, MD
Shannon Rigler, MD
Angela Dimopoulos, MD
Erin Hagen, B.S.
Mehnaz Ali, B.S.

Publications

Refereed Manuscripts

  1. Mills JL, Baker L, Goldman AS. Malformations in infants of diabetic mothers occur before the seventh gestational week: Implications for therapy. Diabetes 1979 Apr; 28(4):292-293. PMID: 437367
  2. Mills JL, Spackman TJ, Borns P, Mandell GA, Schwartz MW. The usefulness of lateral neck roentgenograms in laryngotracheobronchitis. Am J Dis Child 1979; 133(11):1140-1142. PMID: 507005
  3. Bahn AK, Mills JL, Snyder PJ, Gann PH, Houten L, Bialik O, Hollmann L, Utiger RD. Hypothyroidism in workers exposed to polybrominated biphenyls. N Engl J Med 1980 Jan 3; 302(1):31-33. PMID: 6243165. DOI: 10.1056/NEJM198001033020105
  4. Mills JL, Harlap S, Harley EE. Should coitus late in pregnancy be discouraged? Lancet 1981 Jul 18; 2(8238):136-138. PMID: 6113493
  5. Mills JL, Stolley PD, Davies J, Moshang T Jr. Premature Thelarche: Natural history and etiologic investigation. Am J Dis Child 1981 Aug; 135(8):743-745. PMID: 7270520
  6. Stanley CA, Mills JL, Baker L. Intragastric feeding in type I glycogen storage disease: Factors affecting the control of lactic acidemia. Pediatr Res 1981 Dec; 15(12):1504-1508. PMID: 6798537
  7. Mills JL, Harley EE, Berendes HW. Safety of coitus in pregnancy. Lancet 1982 Jan 2; 1(8262):41. PMID: 6119429
  8. Mills JL. Malformations in infants of diabetic mothers. Teratology 1982 Jun; 25(3):385-394. PMID: 7051398. DOI: 10.1002/tera.1420250316 External Web Site Policy
  9. Mills JL, Harley EE, Reed GF, Berendes HW. Are spermicides teratogenic? JAMA 1982 Nov 5; 248(17):2148-2151. PMID: 7120641
  10. Mills JL, Fishl AR, Knopp RH, Ober CL, Jovanovic LG, Polk BF, and the NICHD – Diabetes in Early Pregnancy Study. Malformations in infants of diabetic mothers: Problems in study design. Prev Med 1983 Mar; 12(2):274-286. PMID: 6878189
  11. Mills JL, Harley EE, Moessinger AC. Standards for measuring umbilical cord length. Placenta 1983 Oct-Dec; 4(4):423-4426. PMID: 6634668
  12. Diabetes Research Program - National Institutes of Health. Summary of a Workshop on Immunosuppression in the Management of Type I Diabetes Mellitus (IDDM). N Engl J Med 1983 Nov; 309(19):1199-1200. PMID: 6621673. DOI: 10.1056/NEJM198311103091935 External Web Site Policy
  13. Breskin MW, Worthington-Roberts BS, Knopp RH, Brown Z, Plovie B, Mottet NK, Mills JL. First trimester serum zinc concentrations in human pregnancy. Am J Clin Nutr 1983 Dec; 38(6):943-953. PMID: 6650451
  14. Jovanovic LG, Mills JL, Peterson CM. Anti-insulin antibody titers do not influence control or insulin requirements in early pregnancy. Diabetes Care 1984 Jan-Feb; 7(1):68-71. PMID: 6368152
  15. Mills JL, Jefferys JL, Stolley PD. Effects of occupational exposure to estrogen and progestogens and how to detect them. J Occup Med 1984 Apr; 26(4):269-272. PMID: 6716192
  16. Mills JL, Graubard BI, Harley EE, Rhoads GG, Berendes HW. Maternal alcohol consumption and birth weight: How much drinking during pregnancy is safe? JAMA 1984 Oct 12; 252(14):1875-1879. PMID: 6471316
  17. Shiono PH, Mills. Oral clefts and diazepam use during pregnancy. N Engl J Med 1984 Oct 4; 311(14):919-20. PMID: 6472406. DOI: 10.1056/NEJM198410043111413 External Web Site Policy
  18. Rhoads GG, Mills JL. The role of the case-control study in evaluating health interventions: Vitamin supplementation and neural tube defects. Am J Epidemiol 1984 Dec; 120(6):803-808. PMID: 6391155
  19. Mills JL, Reed GF, Nugent RP, Harley EE, Berendes HW. Are there adverse effects of periconceptional spermicide use? Fertil Steril 1985 Mar; 43(3):442-446. PMID: 3979584
  20. Castracane VD, Jovanovic L, Mills JL. Effect of normoglycemia before conception on early pregnancy hormone profiles. Diabetes Care 1985 Sep-Oct; 8(5):473-476. PMID: 4053934
  21. Klebanoff MA, Mills JL, Berendes HW. Mother's birth weight as a predictor of macrosomia. Am J Obstet Gynecol 1985 Oct; 153(3):253-257. PMID: 4050892
  22. Klebanoff MA, Mills JL. Is vomiting during pregnancy teratogenic? Brit Med J (Clin Res Ed) 1986 Mar 15; 292(6522):724-726. PMID: 3082411. PMCID: PMC1339779
  23. Mills JL, Graubard BI. The effects of moderate drinking during pregnancy. Journal of Obstetrics and Gynaecology 1986; 7 (Sup 1):S6-S6.
  24. Marx SJ, Vinik AI, Santen RJ, Floyd JC Jr, Mills JL, Green J 3rd. Multiple endocrine neoplasia type I: Assessment of laboratory tests to screen for the gene in a large kindred. Medicine 1986 Jul; 65(4):226-241. PMID: 2873498
  25. Mills JL, Shiono PH, Shapiro LR, Crawford PB, Rhoads GG. Early growth predicts timing of puberty in boys: Results of a 14-year nutrition and growth study. J Pediatr 1986 Sep; 109(3):543-547. PMID: 3746550
  26. Rhoads GG, Mills JL. Can vitamin supplements prevent neural tube defects? Current evidence and ongoing investigations. Clin Obstet Gynecol 1986 Sep; 29(3):569-579. PMID: 3530575
  27. Mills JL. Malformations in infants of diabetic mothers. In: John Sever, Robert Brent (eds.). Teratogen Update. Alan R. Liss, New York, 1986, pp. 165-176.
  28. Mills JL, Alexander D. Teratogens and "litogens". N Engl J Med 1986 Nov 6; 315(19):1234-1236. PMID: 3762653. DOI: 10.1056/NEJM198611063151925 External Web Site Policy
  29. Freni-Titulaer LW, Cordero JF, Haddock L, Lebrón G, Martinez R, Mills JL. Premature thelarche in Puerto Rico: A search for environmental factors. Am J Dis Child 1986 Dec; 140(12):1263-1267. PMID: 3776944
  30. Moessinger AC, Mills JL, Harley EE, Ramakrishnan R, Berendes HW, Blanc WA. Umbilical cord length in Down's syndrome. Am J Dis Child 1986 Dec; 140(12):1276-1277. PMID: 2946222
  31. Mills JL, Graubard BI, Klebanoff MA. Association of placenta praevia and sex ratio at birth. Brit Med J (Clin Red Ed) 1987 Feb 28; 294(6571):544. PMID: 3103765. PMCID: PMC1245578
  32. Jovanovic L, Singh M, Saxena BB, Mills JL, Tulchinsky D, Holmes LB, Simpson JL, Metzger BE, LaBarbera A, Aarons J, Van Allen MI; The NICHD-DIEP Study Group. Verification of early pregnancy tests in a multicentered trial. Proc Soc Exp Biol Med 1987 Feb; 184(2):201-205. PMID: 3809174
  33. Mills JL, Graubard BI. Is moderate drinking during pregnancy associated with an increased risk for malformations? Pediatr 1987 Sep; 80(3):309-314. PMID: 3627880
  34. Mills JL. Interpretation of spermicide study data. Am J Public Health 1987 Oct; 77(10):1356-1357. PMID: 3631380. PMCID: PMC1647139
  35. Simpson JL, Mills JL, Holmes LB, Ober CL, Aarons J, Jovanovic L, Knopp RH. Low fetal loss rates after ultrasound-proved viability in early pregnancy. JAMA 1987 Nov 13; 258(18):2555-2557. PMID: 3312659
  36. Mills JL, Knopp RH, Simpson JL, Jovanovic-Peterson L, Metzger BE, Holmes LB, Aarons JH, Brown Z, Reed GF, Bieber FR, Van Allen M, Holzman I, Ober C, Peterson CM, Withiam MJ, Duckles A, Mueller-Heubach E, Polk BF, the National Institute of Child and Human Health Development Diabetes in Early Pregnancy Study. Lack of relation of increased malformation rates in infants of diabetic mothers to glycemic control during organogenesis. N Engl J Med 1988 Mar 17; 318(11):671-676. PMID: 3344018. DOI: 10.1056/NEJM198803173181104 External Web Site Policy
  37. Sweeney AM, Meyer MR, Aarons JH, Mills JL, LaPorte RE. Evaluation of methods for the prospective identification of early fetal losses in environmental epidemiology studies. Am J Epidemiol 1988 Apr; 127(4):843-850. PMID: 3354549
  38. Mills JL, Simpson JL, Driscoll SG, Jovanovic-Peterson L, Van Allen M, Aarons JH, Metzger B, Bieber FR, Knopp RH, Holmes LB, Peterson CM, Withiam-Wilson M, Brown Z, Ober C, Harley E, Macpherson TA, Duckles A, Mueller-Heubach E, the National Institute of Child Health and Human Development-Diabetes in Early Pregnancy Study. Incidence of spontaneous abortion among normal women and insulin-dependent diabetic women whose pregnancies were identified within 21 days of conception. N Engl J Med 1988 Dec 22; 319(25):1617-1623. PMID: 3200277. DOI: 10.1056/NEJM198812223192501 External Web Site Policy
  39. Braunstein GD, Mills JL, Reed GF, Jovanovic LG, Holmes LB, Aarons J, Simpson JL, the NICHD-Diabetes in Early Pregnancy Study Group. Comparison of serum placental protein hormone levels in diabetic and normal pregnancy. J Clin Endocrin Metab 1989 Jan; 68(1):3-8. PMID: 2783318. DOI: 10.1210/jcem-68-1-3 External Web Site Policy
  40. Simpson JL, Mills JL, Morey A, Metzger BE, Knopp RH, Holmes LB, Jovanovic-Peterson L, Aarons JH, Brown Z, Van Allen M, Elias S, the National Institute of Child Health and Human Development Diabetes in Early Pregnancy Study Group. Drug ingestion during pregnancy: infrequent exposure in a contemporary United States sample. Am J Perinatol 1989 Apr; 6(2):244-251. PMID: 2712923. DOI: 10.1055/s-2007-999586 External Web Site Policy
  41. Mills JL, Rhoads GG, Simpson JL, Cunningham GC, Conley MR, Lassman MR, Walden ME, Depp OR, Hoffman HJ, and the NICHD-Neural Tube Defects Study Group. The absence of a relation between the periconceptional use of vitamins and neural-tube defects. N Engl J Med 1989 Aug 17; 321(7):430-435. PMID: 2761577. DOI: 10.1056/NEJM198908173210704 External Web Site Policy
  42. Morin NC, Wirth FH, Johnson DH, Frank LM, Pressburg HJ, Van de Water VL, Chee EM, Mills JL. Congenital malformations and psychosocial development in children conceived by in vitro fertilization. J Pediatr 1989 Aug; 115(2):222-227. PMID: 2666626
  43. Sweeney AM, Meyer MR, Mills JL, Aarons JH, LaPorte RE. Evaluation of recruitment strategies for prospective studies of spontaneous abortion. J Occupat Med 1989 Dec; 31(12):980-985. PMID: 2614538
  44. Mills JL, Simpson JL, Rhoads GG, Graubard BI, Hoffman H, Conley MR, Lassman M, Cunningham G. Risk of neural tube defects in relation to maternal fertility and fertility drug use. The Lancet 1990 Jul 14; 336(8707):103-104. PMID: 1975286
  45. Mills JL, Fradkin J, Schonberger L, Gunn W, Thomson RA, Piper J, Wysowski D, Brown P. Status report on the US human growth hormone recipient follow-up study. Hormone Res 1990; 33(2-4):116-119; discussion 120. PMID: 2210615
  46. Angell M, Mills JL, Ersahin Y. Periconceptional use of multivitamins and the prevalence of neural-tube defects. N Engl J Med 1990 Apr 12; 1990(322):1082-1084. PMID: 2320071. DOI: 10.1056/NEJM199004123221513 External Web Site Policy
  47. Mills JL, Rhoads GG, Simpson JL, Cunningham GC. Vitamins during pregnancy and neural tube defects. JAMA 1990 May 23; 263(20):2747-2748. PMID: 2332916
  48. Mills JL, Klebanoff MA, Graubard BI, Carey JC, Berendes HW. Barrier contraceptive methods and preeclampsia. JAMA 1991 Jan 2; 265(1):70-73. PMID: 1984127
  49. Jovanovic-Peterson L, Peterson CM, Reed GF, Metzger BE, Mills JL, Knopp RH, Aarons JH, and the NICHD-DIEP Study. Maternal postprandial glucose levels and infant birth weight: The Diabetes in Early Pregnancy Study. Am J Obstet Gynecol 1991 Jan; 164(1 Pt 1):103-111. PMID: 1986596
  50. Fradkin JE, Schonberger LB, Mills JL, Gunn WJ, Piper JM, Wysowski DK, Thomson R, Durako S, Brown P. Creutzfeldt-Jakob disease in pituitary growth hormone recipients in the United States. JAMA 1991 Feb 20; 265(7):880-884. PMID: 1992185
  51. Simpson JL, Mills JL, Rhoads GG, Cunningham GC, Hoffman HJ, Conley MR. Vitamins, folic acid and neural tube defects: Comments on investigations in the United States. Prenatal Diagnosis (Special issue relating to International Congress on Early Fetal Diagnosis) 1991 Aug; 11(8):641-648. PMID: 1766937
  52. Simpson JL, Mills JL, Rhoads GG, Cunningham GC, Conley MR, Hoffman HJ. Genetic heterogeneity in neural tube defects. Ann Génét 1991; 34(3-4):279-286. PMID: 1809238
  53. Peterson CM, Jovanovic-Peterson L, Mills JL, Conley MR, Knopp RH, Reed GF, Aarons JH, Holmes LB, Brown Z, Van Allen M, Schmeltz R, Metzger BE, the NICHD-Diabetes in Early Pregnancy Study. The Diabetes in Early Pregnancy Study: Changes in cholesterol, triglycerides, body weight, and blood pressure. Am J Obstet Gynecol 1992 Feb; 166(2):513-518. PMID: 1536221
  54. Brown ZA, Mills JL, Metzger BE, Knopp RH, Simpson JL, Jovanovic-Peterson L, Scheer K, Van Allen MI, Aarons JH, Reed GF, and the National Institute of Child Health and Human Development Diabetes in Early Pregnancy Study. Early sonographic evaluation for fetal growth delay and congenital malformations in pregnancies complicated by insulin-requiring diabetes mellitus. Diabetes Care 1992 May; 15(5):613-619. PMID: 1516479
  55. Mills JL, Tuomilehto J, Yu KF, Colman N, Blaner WS, Koskela P, Rundle WE, Forman M, Toivanen L, Rhoads GG. Maternal vitamin levels during pregnancies producing infants with neural tube defects. J Pediatr 1992 Jun; 120(6):863-871. PMID: 1593344
  56. Mills JL, Holmes LB, Aarons JH, Simpson JL, Brown ZA, Jovanovic-Peterson LG, Conley MR, Graubard BI, Knopp RH, Metzger BE. Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation. JAMA 1993 Feb 3; 269(5):593-597. PMID: 8421363
  57. Mills JL, Raymond E. Effects of recent research on recommendations for periconceptional folate supplement use. Ann N Y Acad Sci 1993 Mar 15; 678:137-145. PMID: 8494256
  58. Jacobson JM, Colman N, Ostrow NA, Simson RW, Tomesch D, Marlin L, Rao M, Mills JL, Clemen J, Prince AM. Passive immunotherapy in the treatment of advanced human immunodeficiency virus infection. J Infect Dis 1993 Aug; 168(2):298-305. PMID: 8101550
  59. Mills JL, Simpson JL. Prospects for prevention of neural tube defects by vitamin supplementation. Current Opinion in Neurology and Neurosurgery 1993 Aug; 6(4):554-558. PMID: 8400468
  60. Raymond EG, Mills JL. Placental abruption: Maternal risk factors and associated fetal conditions. Acta Obstet Gynecol Scand 1993; 72(8):633-639. PMID: 8259750
  61. Klebanoff MA, Read JS, Mills JL, Shiono PH. The risk of childhood cancer after neonatal exposure to vitamin K. N Engl J Med 1993 Sep 23; 329(13):905-908. PMID: 8361503. DOI: 10.1056/NEJM199309233291301 External Web Site Policy
  62. Mills JL. Data torturing. N Engl J Med 1993 Oct 14; 329(16):1196-1199. PMID: 8166792. DOI: 10.1056/NEJM199310143291613 External Web Site Policy
  63. Robins LN, Mills JL, Krulewitch C, Herman AA. Effects of in utero exposure to street drugs. Amer J Publ Hlth 1993 Dec; 83 Suppl:1-32. PMID: 7504891. PMCID: PMC1694390
  64. Fradkin JE, Mills JL, Schonberger LB, Wysowski DK, Thomson R, Durako SJ, Robison LL. Risk of leukemia after treatment with pituitary growth hormone. JAMA 1993 Dec 15; 270(23):2829-2832. PMID: 8133622
  65. Waller KD, Mills JL, Simpson JL, Cunningham GC, Conley MR, Lassman MR, Rhoads GG. Are obese women at higher risk for producing malformed offspring? Am J Obstet Gynecol 1994 Feb; 170(2):541-548. PMID: 8116710
  66. Shu XO, Jin F, Linet MS, Zheng W, Clemens J, Mills J, Gao YT. Diagnostic x-ray and ultrasound exposure and risk of childhood cancer. Brit J Cancer 1994 Sep; 70(3):531-536. PMID: 8080742. PMCID: PMC2033354
  67. Haupt R, Fears TR, Robison LL, Mills JL, Nicholson HS, Zeltzer LK, Meadows AT, Byrne J. Educational attainment in long-term survivors of childhood acute lymphoblastic leukemia. JAMA 1994 Nov 9; 272(18):1427-1432. PMID: 7933424
  68. Mills JL, McPartlin JM, Kirke PN, Lee YJ, Conley MR, Weir DG, Scott JM. Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet 1995 Jan 21; 345(8943):149-151. PMID: 7741859
  69. Shu XO, Hatch MC, Mills J, Clemens J, Susser M. Maternal smoking, alcohol drinking, caffeine consumption, and fetal growth: Results from a prospective study. Epidemiol 1995 Mar; 6(2):115-120. PMID: 7742395
  70. Chew EY, Mills JL, Metzger BE, Remaley NA, Jovanovic-Peterson L, Knopp RH, Conley M, Rand L, Simpson JL, Holmes LB, Aarons JH, and the NICHD Diabetes in Early Pregnancy Study. Metabolic control and progression of retinopathy: The Diabetes in Early Pregnancy Study. Diabetes Care 1995 May; 18(5):631-637. PMID: 8586000
  71. Mills JL, Conley MR. Periconceptional vitamin supplementation to prevent neural tube defects: How can we do it? Eur J Obstet Gynecol Reprod Biol 1995 Jul; 61(1):49-55. PMID: 8549847
  72. Whitehead AS, Gallagher P, Mills JL, Kirke PN, Burke H, Molloy AM, Weir DG, Shields DC, Scott JM. A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects. QJM 1995 Nov; 88(11):763-766. PMID: 8542260
  73. Mills JL, Scott JM, Kirke PN, McPartlin JM, Conley MR, Weir DG, Molloy AM, Lee YJ. Homocysteine and neural tube defects. J Nutr 1996 Mar; 126(3):756S-760S. PMID: 8598561
  74. Simpson JL, Mills JL, Kim H, Holmes LB, Lee J, Metzger B, Knopp R, Jovanovic-Peterson L, Aarons J, Conley M. Infectious processes: an infrequent cause of first trimester spontaneous abortions. Hum Reprod 1996 Mar; 11(3):668-672. PMID: 8671289
  75. Kenney LB, Nicholson HS, Brasseux C, Mills JL, Robison LL, Zeltzer LK, Meadows AT, Reaman GH, Byrne J. Birth defects in offspring of adult survivors of childhood acute lymphoblastic leukemia: a Childrens Cancer Group/National Institutes of Health Report. Cancer 1996 Jul; 78(1):169-176. PMID: 8646713. DOI: 10.1002/(SICI)1097-0142(19960701)78:1<169::AID-CNCR23>3.0.CO;2-X External Web Site Policy
  76. Simpson JL, Carson SA, Mills JL, Conley MR, Aarons J, Holmes LB, Jovanovic-Peterson L, Knopp R, Metzger B. Prospective study showing that antisperm antibodies are not associated with pregnancy losses. Fertil Steril 1996 Jul; 66(1):36-42. PMID: 8752608
  77. Kirke PN, Mills JL, Whitehead AS, Molloy A, Scott JM. Methylenetetrahydrofolate reductase mutation and neural tube defects. Lancet 1996 Oct 12; 348(9033):1037-1038. PMID: 8855891. DOI: 10.1016/S0140-6736(05)64971-9 External Web Site Policy
  78. Mills JL, Conley MR. Folic acid to prevent neural tube defects: scientific advances and public health issues. Curr Opin Obstet Gynecol 1996 Dec; 8(6):394-397. PMID: 8979009
  79. Ramsbottom D, Scott JM, Molloy A, Weir DG, Kirke PN, Mills JL, Gallagher PM, Whitehead AS. Are common mutations of cystathionine beta-synthase involved in the aetiology of neural tube defects? Clin Genet 1997 Jan; 51(1):39-42. PMID: 9084933
  80. Zeltzer LK, Chen E, Weiss R, Guo MD, Robinson LL, Meadows AT, Mills JL, Nicholson HS, Byrne J. Comparison of psychologic outcome in adult survivors of childhood acute lymphoblastic leukemia versus sibling controls: A cooperative Children's Cancer Group and National Institutes of Health study. J Clin Oncol 1997 Feb; 15(2):547-556. PMID: 9053476. DOI: 10.1200/JCO.1997.15.2.547 External Web Site Policy
  81. Molloy AM, Daly S, Mills JL, Kirke PN, Whitehead AS, Ramsbottom D, Conley MR, Weir DG, Scott JM. Thermolabile variant of 5,10 methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. Lancet 1997 May 31; 349(9065):1591-1593. PMID: 9174561. DOI: 10.1016/S0140-6736(96)12049-3
  82. Cnattingius S, Mills JL, Yuen J, Eriksson O, Salonen H. The paradoxical effect of smoking in preeclamptic pregnancies: smoking reduces the incidence but increases the rates of perinatal mortality, abruptio placentae, and intrauterine growth restriction. Am J Obstet Gynecol 1997 Jul; 177(1):156-161. PMID: 9240600
  83. Mills JL, Simpson JL, Cunningham GC, Conley MR, Rhoads GG. Vitamin A and birth defects. Am J Obstet Gynecol 1997 Jul; 177(1):31-36. PMID: 9240579
  84. Mills JL, Fears TR, Robison LL, Nicholson HS, Sklar CA, Byrne J. Menarche in a cohort of 188 long-term survivors of acute lymphoblastic leukemia. J Pediatr 1997 Oct; 131(4):598-602. PMID: 9386666
  85. Kirke PN, Mills JL, Scott JM. Homocysteine metabolism in pregnancies complicated by neural tube defects. J Nutr 1997 Nov-Dec; 13(11-12):994-995. PMID: 9433721
  86. Daly S, Mills JL, Molloy AM, Conley M, Lee YJ, Kirke PN, Weir DG, Scott JM. Minimum effective dose of folic acid for food fortification to prevent neural-tube defects. Lancet 1997 Dec 6; 350(9092):1666-1669. PMID: 9400511. DOI: 10.1016/S0140-6736(97)07247-4 External Web Site Policy
  87. Molloy AM, Mills JL, Kirke PN, Whitehead AS, Weir DG, Scott JM. Whole-blood folate values in subjects with different methylenetetrahydrofolate reductase genotypes: Differences between the radioassay and microbiological assays. Clin Chem 1998 Jan; 44(1):186-188. PMID: 9550581
  88. Chen E, Zeltzer LK, Bentler PM, Byrne J, Nicholson HS, Meadows AT, Mills JL, Haupt R, Fears TR, Robison, LL. Pathways linking treatment intensity and psychosocial outcomes among adult survivors of childhood leukemia. J Health Psychol 1998 Jan; 3(1):23-38. PMID: 22021340. DOI: 10.1177/135910539800300102 External Web Site Policy
  89. Miller RK, Hendrickx AG, Mills JL, Hummler H, Wiegand UW. Periconceptional vitamin A use: how much is teratogenic? Reprod Toxicol 1998 Jan-Feb; 12(1):75-88. PMID: 9431575
  90. Tao ML, Guo MD, Weiss R, Byrne J, Mills JL, Robison LL, Zeltzer LK. Smoking in adult survivors of childhood acute lymphoblastic leukemia. J Natl Cancer Inst 1998 Feb 4; 90(3):219-225. PMID: 9462679
  91. Vargas FR, Roessler E, Gaudenz K, Belloni E, Whitehead AS, Kirke PN, Mills JL, Hooper G, Stevenson RE, Cordeiro I, Correia P, Felix T, Gereige R, Cunningham ML, Canún S, Antonarakis SE, Strachan T, Tsui LC, Scherer SW, Muenke M. Analysis of the human Sonic Hedgehog coding and promoter regions in sacral agenesis, triphalangeal thumb, and mirror polydactyly. Hum Genet 1998 Apr; 102(4):387-392. PMID: 9600232
  92. Simpson JL, Carson SA, Chesney C, Conley MR, Metzger B, Aarons J, Holmes JB, Jovanovic-Peterson L, Knopp R, Mills JL. Lack of association between antiphospholipid antibodies and first-trimester spontaneous abortion: prospective study of pregnancies detected within 21 days of conception. Fertil Steril 1998 May; 69(5):814-820. PMID: 9591485
  93. Molloy AM, Mills JL, Kirke PN, Ramsbottom D, McPartlin JM, Burke H, Conley M, Whitehead AS, Weir DG, Scott JM. Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase: Low folate status alone may be the critical factor. Am J Med Genet 1998 Jun 30; 78(2):155-159. PMID: 9674907
  94. Mills JL, Jovanovic L, Knopp R, Aarons J, Conley M, Park E, Lee YJ, Holmes L, Simpson JL, Metzger B. Physiological reduction in fasting plasma glucose concentration in the first trimester of normal pregnancy: The Diabetes in Early Pregnancy Study. Metabolism 1998 Sep; 47(9):1140-1144. PMID: 9751245
  95. Jovanovic L, Metzger BE, Knopp RH, Conley MR, Park E, Lee YJ, Simpson JL, Holmes L, Aarons JH, Mills JL. The Diabetes in Early Pregnancy Study: Beta-hydroxybutyrate levels in type I diabetic pregnancy compared with normal pregnancy. Diabetes Care 1998 Nov; 21(11):1978-1984. PMID: 9802754
  96. Shields DC, Kirke PN, Mills JL, Ramsbottom D, Molloy AM, Burke H, Weir DG, Scott JM, Whitehead AS. The “thermolabile” variant of methylenetetrahydrofolate reductase and neural tube defects: an evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother. Am J Hum Genet 1999 Apr; 64(4):1045-1055. PMID: 10090889. PMCID: PMC1377828
  97. Whitehead AS, Molloy AM, Ramsbottom D, Weir DG, Kirke PN, Mills JL, Gallagher PM, Scott JM. Gene-gene interactions and neural tube defects. Clin Genet 1999 Feb; 55(2):133-134. PMID: 10189094
  98. Mills JL, DerSimonian R, Raymond E, Morrow JD, Roberts LJ 2nd, Clemens JD, Hauth JC, Catalano P, Sibai B, Curet LB, Levine RJ. Prostacyclin and thromboxane changes predating clinical onset of preeclampsia: a multicenter prospective study. JAMA 1999 Jul 28; 282(4):356-362. PMID: 10432033
  99. Brody LC, Baker PJ, Chines PS, Musick A, Molloy AM, Swanson DA, Kirke PN, Ghoush S, Scott JM, Mills JL. Methionine synthase: high resolution mapping of the human gene and evaluation as a candidate locus for neural tube defects. Mol Genet Metabol 1999 Aug; 67(4): 324-333. PMID: 10444343. DOI: 10.1006/mgme.1999.2881 External Web Site Policy
  100. Mills JL, Kirke PN, Molloy AM, Burke H, Conley MR, Lee YJ, Mayne PD, Weir DG, Scott JM. Methylenetetrahydrofolate reductase thermolabile variant and oral clefts. Am J Med Genet 1999 Sep 3; 86(1):71-74. PMID: 10440833
  101. Daly SF, Molloy AM, Mills JL, Lee YJ, Conley M, Kirke PN, Weir DG, Scott JM. The influence of 5,10 methylenetetrahydrofolate reductase genotypes on enzyme activity in placental tissue. Br J Obstet Gynaecol 1999 Nov; 106(11):1214-1218. PMID: 10549970
  102. Molloy AM, Mills JL, Kirke PN, Weir DG, Scott JM. Folate status and neural tube defects. Biofactors 1999; 10(2-3):291-294. PMID: 10609896
  103. Shields DC, Ramsbottom D, Donoghue C, Pinjon E, Kirke PN, Molloy AM, Edwards YH, Mills JL, Mynett-Johnson L, Weir DG, Scott JM, Whitehead AS. Association between historically high frequencies of neural tube defects and the human T homologue of mouse T (Brachyury). Am J Med Genet 2000 May 29; 92(3):206-211. PMID: 10817656
  104. Mills JL. Fortification of foods with folic acid: how much is enough? N Engl J Med 2000 May 11;342(19): 1442-1445. PMID: 10805832. DOI: 10.1056/NEJM200005113421911 External Web Site Policy
  105. Wright-Pascoe R, Mills J, Choo-Kang E, Morrison EY. The role of C-peptide in the classification of diabetes mellitus. West Indian Med J 2000 Jun; 49(2):138-142. PMID: 10948853
  106. Jovanovic L, Knopp RH, Brown Z, Conley MR, Park E, Mills JL, Metzger BE, Aarons JH, Holmes LB, Simpson JL; National Institute of Child Health and Human Development Diabetes in Early Pregnancy Study Group. Declining insulin requirement in the late first trimester of diabetic pregnancy. Diabetes Care 2001 Jul; 24(7):1130-1136. PMID: 11423491
  107. Feinleib M, Beresford SA, Bowman BA, Mills JL, Rader JI, Selhub J, Yetley EA. Folate fortification for the prevention of birth defects: case study. Am J Epidemiol 2001 Dec; 154(12 Suppl):S60-S69. PMID: 11744531
  108. O’Leary VB, Parle-McDermott A, Molloy AM, Kirke PN, Johnson Z, Conley M, Scott JM, Mills JL. MTRR and MTHFR polymorphism:lLink to Down syndrome? Am J Med Genet 2002 Jan 15; 107(2):151-155. PMID: 11807890
  109. Molloy AM, Mills JL, McPartlin J, Kirke PN, Scott JM, Daly S. Maternal and fetal plasma homocysteine concentrations at birth: The influence of folate, vitamin B12, and the 5,10 methylenetetrahydrofolate reductase 677C-->T variant. Am J Obstet Gynecol 2002 Mar; 186(3):499-503. PMID: 11904614
  110. George L, Mills JL, Johansson AL, Nordmark A, Olander B, Granath F, Cnattingius S. Plasma folate levels and risk of spontaneous abortion. JAMA 2002 Oct 16; 288(15):1867-1873. PMID: 12377085
  111. Daly S, Mills JL, Molloy AM, Conley M, McPartlin J, Lee YJ, Young PB, Kirke PN, Weir DG, Scott JM. Low-dose folic acid lowers plasma homocysteine levels in women of child-bearing age. Q J M 2002 Nov; 95(11):733-740. PMID: 12391385
  112. Brody LC, Conley M, Cox C, Kirke PN, McKeever MP, Mills JL, Molloy AM, O’Leary VB, Parle-McDermott A, Scott JM, Swanson DA. A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group. Am J Hum Genet 2002 Nov; 71(5):1207-1215. PMID: 12384833. PMCID: PMC385099. DOI: 10.1086/344213
  113. Parle-McDermott A, Mills JL, Kirke PN, O’Leary VB, Swanson DA, Pangilanin F, Conley M, Molloy AM, Cox C, Scott JM, Brody LC. Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects. J Hum Genet 2003; 48(4):190-193. PMID: 12730722. DOI: 10.1007/s10038-003-0008-4 External Web Site Policy
  114. Mills JL, England L, Granath F, Cnattinguis S. Cigarette smoking and the male-female sex ratio. Fertil Steril 2003 May; 79(5):1243-1245. PMID: 12738529
  115. Mills JL, Von Kohorn I, Conley MR, Zeller JA, Cox C, Williamson RE, Dufour DR. Low vitamin B-12 concentrations in patients without anemia: the effect of folic acid fortification of grain. Amer J Clin Nutr 2003 Jun; 77(6):1474-1477. PMID: 12791626
  116. O’Leary VB, Mills JL, Kirke PN, Parle-McDermott A, Swanson DA, Weiler A, Pangilinan F, Conley M, Molloy AM, Lynch M, Cox C, Scott JM, Brody LC. Analysis of the human folate receptor beta gene for an association with neural tube defects. Mol Genet Metabol 2003 Jun; 79(2):129-133. PMID: 12809644
  117. England LJ, Levine RJ, Mills JL, Klebanoff MA, Yu KF, Cnattingius S. Adverse pregnancy outcomes in snuff users. Am J Obstet Gynecol 2003 Oct; 189(4):939-943. PMID: 14586330
  118. Parle-Mc Dermott A, McManus EJ, Mills JL, O’Leary VB, Pangilinan F, Cox C, Weiler A, Molloy AM, Conley M, Watson D, Scott JM, Brody LC, Kirke PN; Birth Defects Research Group. Polymorphisms within the vitamin B12 dependent methylmalonyl-coA mutase are not risk factors for neural tube defects. Mol Genet Metabol 2003 Dec; 80(4):463-468. PMID: 14654360
  119. Glover DA, Byrne J, Mills JL, Robison LL, Nicholson HS, Meadows A, Zeltzer LK; Children’s Cancer Group. Impact of CNS treatment on mood in adult survivors of childhood leukemia: A report from the Children’s Cancer Group. J Clin Oncol 2003 Dec; 21(23):4395-401. PMID: 14645430. PMCID: PMC1459335. DOI: 10.1200/JCO.2003.04.089 External Web Site Policy
  120. Avaria Mde L, Mills JL, Kleinsteuber K, Aros S, Conley MR, Cox C, Klebanoff M, Cassorla F. Peripheral nerve conduction abnormalities in children exposed to alcohol in utero. J Pediatr 2004; 144(3):338-343. PMID: 15001939. DOI: 10.1016/j.jpeds.2003.11.028 External Web Site Policy
  121. Seitzman RL, Glover DA, Meadows AT, Mills JL, Nicholson HS, Robison LL, Byrne J, Zeltzer LK. Self-concept in adult survivors of childhood acute lymphoblastic leukemia: A Cooperative Children’s Cancer Group and National Institutes of Health Study. Pediatr Blood Cancer 2004 Mar; 42(3):230-240. PMID: 14752860. DOI: 10.1002/pbc.10434 External Web Site Policy
  122. Mills JL, Schonberger LB, Wysowski DK, Brown P, Durako SJ, Cox C, Kong F, Fradkin JE. Long-term mortality in the United States cohort of pituitary-derived growth hormone recipients. J Pediatr 2004 Apr; 144(4):430-436. PMID: 15069388. DOI: 10.1016/j.jpeds.2003.12.036 External Web Site Policy
  123. Byrne J, Fears TR, Mills JL, Zeltzer LK, Sklar C, Meadows AT, Reaman GH, Robison LL. Fertility of long-term male survivors of acute lymphoblastic leukemia diagnosed during childhood. Pediatr Blood Cancer 2004 Apr; 42(4):364-372. PMID: 14966835. DOI: 10.1002/pbc.10449 External Web Site Policy
  124. Mills JL, Signore CC. Folic acid and the prevention of neural-tube defects. N Engl J Med. 2004 May 20; 350(21):2209-2211. PMID: 15152070. DOI: 10.1056/NEJM200405203502120 External Web Site Policy
  125. Kirke PN, Mills JL, Molloy AM, Brody LC, O’Leary VB, Daly L, Murray S, Conley M, Mayne PD, Smith O, Scott JM. Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study. Brit Med J 2004 Jun 26; 328(7455):1535-1536. PMID: 15155469. PMCID: PMC437144. DOI: 10.1136/bmj.38036.646030.EE External Web Site Policy
  126. Byrne J, Fears TR, Mills JL, Zeltzer LK, Sklar C, Nicholson HS, Haupt R, Reaman GH, Meadows AT, Robison LL. Fertility in women treated with cranial radiotherapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2004 Jun; 42(7):589-597. PMID: 15127413. DOI: 10.1002/pbc.20033 External Web Site Policy
  127. Rao MR, Brenner RA, Schisterman EF, Vik T, Mills JL. Impaired long term cognitive development in children with persistent crying. Arch Dis Child 2004 Nov; 89(11):989-992. PMID: 15499048. PMCID: PMC1719720. DOI: 10.1136/adc.2003.039198 External Web Site Policy
  128. Mills JL, Signore C. Neural tube defect rates before and after food fortification with folic acid. Birth Defects Res A Clin Mol Teratol 2004 Nov; 70(11):844-845. PMID: 15468072. DOI: 10.1002/bdra.20075 External Web Site Policy
  129. Parle-McDermott A, Mills JL, Kirke PN, Cox C, Signore CC, Kirke S, Molloy AM, O’Leary VB, Pangilinan FJ, O’Herlihy C, Brody LC, Scott JM. MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae. Amer J Med Genet A 2005 Feb 1; 132A(4):365-368. PMID: 15633187. DOI: 10.1002/ajmg.a.30354 External Web Site Policy
  130. Swanson DA, Pangilinan F, Mills JL, Kirke PN, Conley M, Weiler A, Frey T, Parle-McDermott A, O'Leary VB, Seltzer RR, Moynihan KA, Molloy AM, Burke H, Scott JM, Brody LC. Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population. Birth Defects Res A Clin Mol Teratol 2005 Apr; 73(4):239-244. PMID: 15782407. DOI: 10.1002/bdra.20122 External Web Site Policy
  131. Signore C, Mills JL, Cox C, Trumble AC. Effects of folic acid fortification on twin gestation rates. Obstet Gynecol 2005 Apr; 105(4):757-62. PMID: 15802402. DOI: 10.1097/01.AOG.0000154886.40318.5e External Web Site Policy
  132. Jovanovic L, Knopp RH, Kim H, Cefalu WT, Zhu XD, Lee YJ, Simpson JL, Mills JL. Elevated pregnancy losses at high and low extremes of maternal glucose in early normal and diabetic pregnancy: Evidence for a protective adaptation in diabetes. Diabetes Care 2005 May; 28(5):1113-1117. PMID: 15855575
  133. O’Leary VB, Mills JL, Pangilinan F, Kirke PN, Cox C, Conley M, Weiler A, Peng K, Shane B, Scott JM, Parle-McDermott A, Molloy AM, Brody LC; Members of the Birth Defects Research Group. Analysis of methionine synthase reductase polymorphisms for neural tube defect association. Mol Genet Metab 2005 Jul; 85(3):220-227. PMID: 15979034. DOI: 10.1016/j.ymgme.2005.02.003 External Web Site Policy
  134. Parle-McDermott A, Pangilinan F, Mills JL, Signore CC, Molloy AM, Cotter A, Conley M, Cox C, Kirke PN, Scott JM, Brody LC. A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss. Mol Hum Reprod 2005 Jul; 11(7):477-480. PMID: 16123074. DOI: 10.1093/molehr/gah204 External Web Site Policy
  135. Mills JL, Druschel CM, Pangilinan F, Pass K, Cox C, Seltzer RR, Conley MR, Brody LC. Folate-related genes and omphalocele. Am J Med Genet A 2005 Jul 1; 136(1):8-11. PMID: 15937947. DOI: 10.1002/ajmg.a.30772 External Web Site Policy
  136. O'Leary VB, Mills JL, Parle-McDermott A, Pangilinan F, Molloy AM, Cox C, Weiler A, Conley M, Kirke PN, Scott JM, Brody LC; Birth Defects Research Group. Screening for new MTHFR polymorphisms and NTD risk. Am J Med Genet A 2005 Oct 1; 138A(2):99-106. PMID: 16145688. DOI: 10.1002/ajmg.a.30846 External Web Site Policy
  137. Molloy AM, Mills JL, Cox C, Daly SF, Conley M, Brody LC, Kirke PN, Scott JM, Ueland PM. Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery. Am J Clin Nutr 2005 Oct; 82(4):836-842. PMID: 16210714
  138. O'Leary VB, Pangilinan F, Cox C, Parle-McDermott A, Conley M, Molloy AM, Kirke PN, Mills JL, Brody LC, Scott JM; Members of the Birth Defects Research Group. Reduced folate carrier polymorphisms and neural tube defect risk. Mol Genet Metab 2006 Apr; 87(4):364-369. PMID: 16343969. DOI: 10.1016/j.ymgme.2005.09.024 External Web Site Policy
  139. Aros S, Mills JL, Torres C, Henriquez C, Fuentes A, Capurro T, Mena M, Conley M, Cox C, Signore C, Klebanoff M, Cassorla F. Prospective identification of pregnant women drinking four or more standard drinks (> or = 48 g) of alcohol per day. Subst Use Misuse 2006; 41(2):183-197. PMID: 16479683
  140. Parle-McDermott A, Kirke PN, Mills JL, Molloy AM, Cox C, O'Leary VB, Pangilinan F, Conley M, Cleary L, Brody LC, Scott JM. Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population. Eur J Hum Genet 2006 Jun; 14(6):768-772. PMID: 16552426. DOI: 10.1038/sj.ejhg.5201603 External Web Site Policy
  141. Parle-McDermott A, Mills JL, Molloy AM, Carroll N, Kirke PN, Cox C, Conley MR, Pangilinan FJ, Brody LC, Scott JM. The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels. Mol Genet Metab 2006 Jul; 88(3):290-294. PMID: 16621645. DOI: 10.1016/j.ymgme.2006.02.011 External Web Site Policy
  142. Signore C, Mills JL, Qian C, Yu K, Lam C, Epstein FH, Karumanchi SA, Levine RJ. Circulating angiogenic factors and placental abruption. Obstet Gynecol 2006 Aug; 108(2):338-344. PMID: 16880304. DOI: 10.1097/01.AOG.0000216014.72503.09 External Web Site Policy
  143. Parle-McDermott A, Pangilinan F, Mills JL, Kirke PN, Gibney ER, Troendle J, O'Leary VB, Molloy AM, Conley M, Scott JM, Brody LC. The 19-bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR) may decrease rather than increase risk for spina bifida in the Irish population. Am J Med Genet A 2007 Jun 1; 143A(11):1174-1180. PMID: 17486595. DOI: 10.1002/ajmg.a.31725 External Web Site Policy
  144. Mills JL, Hediger ML, Molloy CA, Chrousos GP, Manning-Courtney P, Yu KF, Brasington M, England LJ. Elevated levels of growth-related hormones in autism and autism spectrum disorder. Clin Endocrinol (Oxf) 2007 Aug; 67(2):230-237. PMID: 17547689. DOI: 10.1111/j.1365-2265.2007.02868.x External Web Site Policy
  145. Signore C, Ueland PM, Troendle J, Mills JL. Choline concentrations in human maternal and cord blood and intelligence at 5 y of age. Am J Clin Nutr 2008 Apr; 87(4):896-902. PMID: 18400712. PMCID: PMC2423009
  146. Hediger ML, England LJ, Molloy CA, Yu KF, Manning-Courtney P, Mills JL. Reduced bone cortical thickness in boys with autism or autism spectrum disorder. J Autism Dev Disord 2008 May; 38(5):848-856. PMID: 17879151. DOI: 10.1007/s10803-007-0453-6 External Web Site Policy
  147. Mills JL, Molloy AM, Parle-McDermott A, Troendle JF, Brody LC, Conley MR, Cox C, Pangilinan F, Orr DJ, Earley M, McKiernan E, Lynn EC, Doyle A, Scott JM, Kirke PN. Folate-Related Gene Polymorphisms as Risk Factors for Cleft Lip and Cleft Palate. Birth Defects Res A Clin Mol Teratol 2008 Sep; 82(9):636-643. PMID: 18661527. PMCID: PMC2670560. DOI: 10.1002/bdra.20491 External Web Site Policy
  148. Signore C, Mills JL, Qian C, Yu KF, Rana S, Karumanchi SA, Levine RJ. Circulating soluble endoglin and placental abruption. Prenat Diagn 2008 Sep; 28(9):852-858. PMID: 18702104. PMCID: PMC2574843. DOI: 10.1002/pd.2065 External Web Site Policy
  149. Flanigan EY, Aros S, Bueno MF, Conley M, Troendle JF, Cassorla F, Mills JL. Eye malformations in children with heavy alcohol exposure in utero. J Pediatr 2008 Sep; 153(3):391-395. PMID: 18571671. PMCID: PMC2570183. DOI: 10.1016/j.jpeds.2008.04.024 External Web Site Policy
  150. Pangilinan F, Geiler K, Dolle J, Troendle J, Swanson DA, Molloy AM, Sutton M, Conley M, Kirke PN, Scott JM, Mills JL, Brody LC. Construction of a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population. Am J Med Genet A 2008 Oct 15; 146A(20):2617-2625. PMID: 18798306. PMCID: PMC2836760. DOI: 10.1002/ajmg.a.32504 External Web Site Policy
  151. Signore C, Aros S, Morrow JD, Troendle J, Conley MR, Flanigan EY, Cassorla F, Mills JL. Markers of oxidative stress and systemic vasoconstriction in pregnant women drinking > or = 48 g of alcohol per day. Alcohol Clin Exp Res 2008 Nov; 32(11):1893-1898. PMID: 18715278. PMCID: PMC2615682. DOI: 10.1111/j.1530-0277.2008.00773.x External Web Site Policy
  152. Mitchell A, Pangilinan P, VanderMeer J, Molloy AM, Troendle J, Conley M, Kirke PN, Scott JM, Brody LC, Mills JL. Uncoupling protein 2 polymorphisms as risk factors for NTDs. Birth Defects Res A Clin Mol Teratol 2009 Feb; 85(2):156-160. PMID: 19137581. PMCID: PMC2724655. DOI: 10.1002/bdra.20520 External Web Site Policy
  153. Molloy AM, Kirke PN, Troendle JF, Burke H, Sutton M, Brody LC, Scott JM, Mills JL. Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic acid fortification. Pediatr 2009 Mar; 123(3):917-923. PMID: 19255021. PMCID: PMC4161975. DOI: 10.1542/peds.2008-1173 External Web Site Policy
  154. Troendle JF, Yu KF, Mills JL. Testing for genetic association with constrained models using triads. Ann Hum Genet 2009 Mar; 73(2):225-230. PMID: 19178434. PMCID: PMC2657230. DOI: 10.1111/j.1469-1809.2008.00494.x External Web Site Policy
  155. Carroll N, Pangilinan F, Molloy AM, Troendle J, Mills JL, Kirke PN, Brody LC, Scott JM, Parle-McDermott A. Analysis of the MTHFD1 promoter and risk of neural tube defects. Hum Genet 2009 Apr; 125(3):247-256. PMID: 19130090. PMCID: PMC2732995. DOI: 10.1007/s00439-008-0616-3 External Web Site Policy
  156. Molloy AM, Brody LC, Mills JL, Scott JM, Kirke PN. The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects. Birth Defects Res A Clin Mol Teratol 2009 Apr; 85(4):285-294. PMID: 19235830. DOI: 10.1002/bdra.20566 External Web Site Policy
  157. Molloy AM, Quadros EV, Sequeira JM, Troendle JF, Scott JM, Kirke PN, Mills JL. Lack of association between folate-receptor autoantibodies and neural-tube defects. N Engl J Med 2009 Jul 9; 361(2):152-160. PMID: 19587340. PMCID: PMC4149290. DOI: 10.1056/NEJMoa0803783 External Web Site Policy
  158. Parle-McDermott A, Pangilinan F, O'Brien KK, Mills JL, Magee AM, Troendle J, Sutton M, Scott JM, Kirke PN, Molloy AM, Brody LC. A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency. Hum Mutat 2009 Dec; 30(12):1650-1656. PMID: 19777576. PMCID: PMC2787683. DOI: 10.1002/humu.21109 External Web Site Policy
  159. Carter TC, Molloy AM, Pangilinan F, Troendle JF, Kirke PN, Conley MR, Orr DJ, Earley M, McKiernan E, Lynn EC, Doyle A, Scott JM, Brody LC, Mills JL. Testing reported associations of genetic risk factors for oral clefts in a large Irish study population. Birth Defects Res A Clin Mol Teratol 2010 Feb; 88(2):84-93. PMID: 19937600. PMCID: PMC3503531. DOI: 10.1002/bdra.20639 External Web Site Policy
  160. Moslehi R, Signore C, Tamura D, Mills JL, Digiovanna JJ, Tucker MA, Troendle J, Ueda T, Boyle J, Khan SG, Oh KS, Goldstein AM, Kraemer KH. Adverse effects of trichothiodystrophy DNA repair and transcription gene disorder on human fetal development. Clin Genet 2010 Apr; 77(4):365-373. PMID: 20002457. PMCID: PMC3463936. DOI: 10.1111/j.1399-0004.2009.01336.x External Web Site Policy
  161. Beaty TH, Murray JC, Marazita ML, Munger RG, Ruczinski I, Hetmanski JB, Liang KY, Wu T, Murray T, Fallin MD, Redett RA, Raymond G, Schwender H, Jin SC, Cooper ME, Dunnwald M, Mansilla MA, Leslie E, Bullard S, Lidral AC, Moreno LM, Menezes R, Vieira AR, Petrin A, Wilcox AJ, Lie RT, Jabs EW, Wu-Chou YH, Chen PK, Wang H, Ye X, Huang S, Yeow V, Chong SS, Jee SH, Shi B, Christensen K, Melbye M, Doheny KF, Pugh EW, Ling H, Castilla EE, Czeizel AE, Ma L, Field LL, Brody L, Pangilinan F, Mills JL, Molloy AM, Kirke PN, Scott JM, Arcos-Burgos M, Scott AF. A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. Nat Genet 2010 Jun; 42(6):525-529. PMID: 20436469. PMCID: PMC2941216. DOI: 10.1038/ng.580 External Web Site Policy
  162. Bloom MS, Houston AS, Mills JL, Molloy CA, Hediger ML. Finger bone immaturity and 2D:4D ratio measurement error in the assessment of the hyperandrogenic hypothesis for the etiology of autism spectrum disorders. Physiol Behav 2010 Jun 1; 100(3):221-224. PMID: 20093135. PMCID: PMC2897171. DOI: 10.1016/j.physbeh.2010.01.005 External Web Site Policy
  163. Mills JL, Troendle J, Conley MR, Carter T, Druschel CM. Maternal obesity and congenital heart defects: a population-based study. Am J Clin Nutr 2010 Jun; 91(6):1543-1549. PMID: 20375192. PMCID: PMC2869507. DOI: 10.3945/ajcn.2009.28865 External Web Site Policy
  164. Bailey RL, Mills JL, Yetley EA, Gahche JJ, Pfeiffer CM, Dwyer JT, Dodd KW, Sempos CT, Betz JM, Picciano MF. Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged > or =60 y in the United States. Am J Clin Nutr 2010 Aug; 92(2):383-389. PMID: 20573790. PMCID: PMC2904036. DOI: 10.3945/ajcn.2010.29499 External Web Site Policy
  165. Mills JL. Malformations in infants of diabetic mothers. Teratology 25:385-94. 1982. Birth Defects Res A Clin Mol Teratol. 2010 Oct; 88(10):769-778. PMID: 20973049. PMCID: PMCID: PMC4158942. DOI: 10.1002/bdra.20757 External Web Site Policy
  166. Pangilinan F, Mitchell A, VanderMeer J, Molloy AM, Troendle J, Conley M, Kirke PN, Sutton M, Sequeira JM, Quadros EV, Scott JM, Mills JL, Brody LC. Transcobalamin II receptor polymorphisms are associated with increased risk for neural tube defects. J Med Genet 2010 Oct; 47(1):677-685. PMID: 20577008. PMCID: PMC4112773. DOI: 10.1136/jmg.2009.073775 External Web Site Policy
  167. Molloy CA, Kalkwarf HJ, Manning-Courtney P, Mills JL, Hediger ML. Plasma 25(OH)D concentration in children with autism spectrum disorder. Dev Med Child Neurol 2010 Oct; 52(10):969-971. PMID: 20497452. PMCID: PMC2939162. DOI: 10.1111/j.1469-8749.2010.03704.x External Web Site Policy
  168. Obican SG, Finnell RH, Mills JL, Shaw GM, Scialli AR. Folic acid in early pregnancy: a public health success story. FASEB J. 2010 Nov; 24(11):4167-4174. PMID: 20631328. PMCID: PMC2974421. DOI: 10.1096/fj.10-165084 External Web Site Policy
  169. Carter TC, Pangilinan F, Troendle JF, Molloy AM, VanderMeer J, Mitchell A, Kirke PN, Conley MR, Shane B, Scott JM, Brody LC, Mills JL. Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population. Am J Med Genet A 2011 Jan; 155A(1):14-21. PMID: 21204206. PMCID: PMC3503244. DOI: 10.1002/ajmg.a.33755 External Web Site Policy
  170. Troendle JF, Mills JL. Correction for multiplicity in genetic association studies of triads: the permutation TDT. Ann Hum Genet 2011 Mar; 75(2):284-291. PMID: 21108625. PMCID: PMC3117224. DOI: 10.1111/j.1469-1809.2010.00626.x External Web Site Policy
  171. Aros S, Mills JL, Iñiguez G, Avila A, Conley MR, Troendle J, Cox C, Cassorla F. Effects of prenatal ethanol exposure on postnatal growth and the insulin-like growth factor axis. Horm Res Paediatr 2011; 75(3):166-173. PMID: 20847545. PMCID: PMC3068754. DOI: 10.1159/000319706 External Web Site Policy
  172. Sutton M, Mills JL, Molloy AM, Troendle JF, Brody LC, Conley M, Mc Donnell R, Scott JM, Kirke PN. Maternal folate, vitamin B12 and homocysteine levels in pregnancies affected by congenital malformations other than neural tube defects. Birth Defects Res A Clin Mol Teratol 2011 Jul; 91(7):610-615. PMID: 21591245. PMCID: PMC3372895. DOI: 10.1002/bdra.20817 External Web Site Policy
  173. Yetley EA, Pfeiffer CM, Phinney KW, Bailey RL, Blackmore S, Bock JL, Brody LC, Carmel R, Curtin LR, Durazo-Arvizu RA, Eckfeldt JH, Green R, Gregory JF 3rd, Hoofnagle AN, Jacobsen DW, Jacques PF, Lacher DA, Molloy AM, Massaro J, Mills JL, Nexo E, Rader JI, Selhub J, Sempos C, Shane B, Stabler S, Stover P, Tamura T, Tedstone A, Thorpe SJ, Coates PM, Johnson CL, Picciano MF. Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr 2011 Jul; 94(1):313S-321S. PMID: 21593502. PMCID: PMC3127527. DOI: 10.3945/ajcn.111.013243 External Web Site Policy
  174. Stone N, Pangilinan F, Molloy AM, Shane B, Scott JM, Ueland PM, Mills JL, Kirke PN, Sethupathy P, Brody LC. Bioinformatic and genetic association analysis of microRNA target sites in one-carbon metabolism genes. PLoS One 2011; 6(7):e21851. PMID: 21765920. PMCID: PMC3134459. DOI: 10.1371/journal.pone.0021851 External Web Site Policy
  175. Mills JL, Carter TC, Scott JM, Troendle JF, Gibney ER, Shane B, Kirke PN, Ueland PM, Brody LC, Molloy AM. Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status? Am J Clin Nutr 2011 Aug; 94(2):495-500. PMID: 21653798. PMCID: PMC3142724. DOI: 10.3945/ajcn.111.014621 External Web Site Policy
  176. Abrams JY, Schonberger LB, Belay ED, Maddox RA, Leschek EW, Mills JL, Wysowski DK, Fradkin JE. Lower risk of Creutzfeldt-Jakob disease in pituitary growth hormone recipients initiating treatment after 1977. J Clin Endocrinol Metab 2011 Oct; 96(10):E1666-E1669. PMID: 21816775. DOI: 10.1210/jc.2011-1357 External Web Site Policy
  177. Murphy LE, Mills JL, Molloy AM, Qian C, Carter TC, Strevens H, Wide-Swensson D, Giwercman A, Levine RJ. Folate and vitamin B12 in idiopathic male infertility. Asian J Androl 2011 Nov; 13(6):856-861. PMID: 21857689. PMCID: PMC3372894. DOI: 10.1038/aja.2011.96 External Web Site Policy
  178. Bailey RL, Mills JL, Yetley EA, Gahche JJ, Pfeiffer CM, Dwyer JT, Dodd KW, Sempos CT, Betz JM, Picciano MF. Serum unmetabolized folic acid in a nationally representative sample of adults ≥60 years in the United States, 2001-2002. Food Nutr Res 2012;56. PMID: 22489216. PMCID: PMC3321249. DOI: 10.3402/fnr.v56i0.5616 External Web Site Policy
  179. Minguzzi S, Molloy AM, Peadar K, Mills J, Scott JM, Troendle J, Pangilinan F, Brody L, Parle-McDermott A. Genotyping of a tri-allelic polymorphism by a novel melting curve assay in MTHFD1L: an association study of nonsyndromic Cleft in Ireland. BMC Med Genet 2012 Apr 20; 13:29. PMID: 22520921. PMCID: PMC3419639. DOI: 10.1186/1471-2350-13-29 External Web Site Policy
  180. Cornman-Homonoff J, Kuehn D, Aros S, Carter TC, Conley MR, Troendle J, Cassorla F, Mills JL. Heavy prenatal alcohol exposure and risk of stillbirth and preterm delivery. J Matern Fetal Neonatal Med 2012 Jun; 25(6):860-863. PMID: 21728738. PMCID: PMC4148070. DOI: 10.3109/14767058.2011.587559 External Web Site Policy
  181. Moslehi R, Kumar A, Mills JL, Ambroggio X, Signore C, Dzutsev A. Phenotype-specific adverse effects of XPD mutations on human prenatal development implicate impairment of TFIIH-mediated functions in placenta. Eur J Hum Genet 2012 Jun; 20(6):626-631. PMID: 22234153. PMCID: PMC3355251. DOI: 10.1038/ejhg.2011.249 External Web Site Policy
  182. Mills JL, Carter TC, Kay DM, Browne ML, Brody LC, Liu A, Romitti PA, Caggana M, Druschel CM. Folate and vitamin B12-related genes and risk for omphalocele. Hum Genet 2012; 131(5):739-746. PMID: 22116453. PMCID: PMC3374579. DOI: 10.1007/s00439-011-1117-3 External Web Site Policy
  183. Minguzzi S, Molloy AM, Kirke PN, Mills JL, Scott JM, Troendle J, Pangilinan F, Brody LC, Parle-McDermott A. Development of a melting curve assay to genotype a tri-allelic polymorphism of MTHFD1L: an association study of nonsyndromic Cleft in Ireland. BMC Med Genet 2012; 13:29.
  184. Carter TC, Kay DM, Browne ML, Liu A, Romitti PA, Kuehn D, Conley MR, Caggana M, Druschel CM, Brody LC, Mills JL. Hirschsprung's disease and variants in genes that regulate enteric neural crest cell proliferation, migration and differentiation. J Hum Genet 2012 Aug; 57(8):485-493. PMID: 22648184. PMCID: PMC3503526. DOI: 10.1038/jhg.2012.54 External Web Site Policy
  185. Pangilinan F, Molloy AM, Mills JL, Troendle JF, Parle-McDermott A, Signore C, O'Leary VB, Chines P, Seay JM, Geiler-Samerotte K, Mitchell A, VanderMeer JE, Krebs KM, Sanchez A, Cornman-Homonoff J, Stone N, Conley M, Kirke PN, Shane B, Scott JM, Brody LC. Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects. BMC Med Genet 2012 Aug 2; 13:62. PMID: 22856873. PMCID: PMC3458983. DOI: 10.1186/1471-2350-13-62 External Web Site Policy
  186. Kuehn D*, Aros S*, Cassorla C, Avaria M, Unanue N, Henriquez C, Kleinsteuber K, Conca B, Avila A, Carter TC, Conley MR, Troendle J, Mills JL. *These authors contributed equally to this manuscript. A prospective cohort study of the prevalence of growth, facial, and central nervous system abnormalities in children with heavy prenatal alcohol exposure. Alcohol Clin Exp Res 2012 Oct; 36(10):1811-1819. PMID: 22823161. PMCID: PMC4162305. DOI: 10.1111/j.1530-0277.2012.01794.x External Web Site Policy
  187. Browne ML, Carter TC, Kay DM, Kuehn D, Brody LC, Romitti PA, Liu A, Caggana M, Druschel CM, Mills JL. Evaluation of genes involved in limb development, angiogenesis, and coagulation as risk factors for congenital limb deficiencies. Am J Med Genet A 2012 Oct; 158A(10):2463-2472. PMID: 22965740. PMCID: PMC3448837. DOI: 10.1002/ajmg.a.35565 External Web Site Policy
  188. Justice CM, Yagnik G, Kim Y, Peter I, Jabs EW, Erazo M, Ye X, Ainehsazan E, Shi L, Cunningham ML, Kimonis V, Roscioli T, Wall SA, Wilkie AO, Stoler J, Richtsmeier JT, Heuzé Y, Sanchez-Lara PA, Buckley MF, Druschel CM, Mills JL, Caggana M, Romitti PA, Kay DM, Senders C, Taub PJ, Klein OD, Boggan J, Zwienenberg-Lee M, Naydenov C, Kim J, Wilson AF, Boyadjiev SA. A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9. Nat Genet 2012 Dec; 44(12):1360-1364. PMID: 23160099. PMCID: PMC3736322. DOI: 10.1038/ng.2463
  189. Carter TC, Kay DM, Browne ML, Liu A, Romitti PA, Kuehn D, Conley MR, Caggana M, Druschel CM, Brody LC, Mills JL. Anorectal atresia and variants at predicted regulatory sites in candidate genes. Ann Hum Genet 2013 Jan; 77(1):31-46. PMID: 23127126. PMCID: PMC3535506. DOI: 10.1111/j.1469-1809.2012.00734.x External Web Site Policy
  190. Desch KC, Ozel AB, Siemieniak D, Kalish Y, Shavit JA, Thornburg CD, Sharathkumar AA, McHugh CP, Laurie CC, Crenshaw A, Mirel DB, Kim Y, Cropp CD, Molloy AM, Kirke PN, Bailey-Wilson JE, Wilson AF, Mills JL, Scott JM, Brody LC, Li JZ, Ginsburg D. Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Proc Natl Acad Sci U S A 2013 Jan 8; 110(2):588-593. PMID: 23267103. PMCID: PMC3545809. DOI: 10.1073/pnas.1219885110 External Web Site Policy
  191. Irwin DJ, Abrams JY, Schonberger LB, Leschek EW, Mills JL, Lee VM, Trojanowski JQ. Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone. JAMA Neurol 2013 Apr; 70(4):462-468. PMID: 23380910. PMCID: PMC3678373. DOI: 10.1001/jamaneurol.2013.1933 External Web Site Policy
  192. Moslehi R, Mills JL, Signore C, Kumar A, Ambroggio X, Dzutsev A. Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia. Sci Rep 2013; 3:2407. PMID: 23989136. PMCID: PMC3757356. DOI: 10.1038/srep02407 External Web Site Policy
  193. Brite J, Laughon SK, Troendle J, Mills J. Maternal overweight and obesity and risk of congenital heart defects in offspring. Int J Obes (Lond) 2013 Jun; 38(6):878-882. PMID: 24362506. PMCID: PMC4053485. DOI: 10.1038/ijo.2013.244 External Web Site Policy
  194. Mamasoula C, Prentice RR, Pierscionek T, Pangilinan F, Mills JL, Druschel C, Pass K, Russell MW, Hall D, Töpf A, Brown DL, Zelenika D, Bentham J, Cosgrove C, Bhattacharya S, Riveron JG, Setchfield K, Brook JD, Bu'Lock FA, Thornborough C, Rahman TJ, Doza JP, Tan HL, O'Sullivan J, Stuart AG, Blue G, Winlaw D, Postma AV, Mulder BJ, Zwinderman AH, van Engelen K, Moorman AF, Rauch A, Gewillig M, Breckpot J, Devriendt K, Lathrop GM, Farrall M, Goodship JA, Cordell HJ, Brody LC, Keavney BD. Association between C677T polymorphism of methylene tetrahydrofolate reductase and congenital heart disease: meta-analysis of 7697 cases and 13,125 controls. Circ Cardiovasc Genet 2013 Aug; 6(4):347-353. PMID: 23876493. PMCID: PMC3855044. DOI: 10.1161/CIRCGENETICS.113.000191
  195. Feenstra B, Geller F, Carstensen L, Romitti PA, Körberg IB, Bedell B, Krogh C, Fan R, Svenningsson A, Caggana M, Nordenskjöld A, Mills JL, Murray JC, Melbye M. Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis. JAMA 2013 Aug 21; 310(7):714-721. PMID: 23989729. PMCID: PMC4031654. DOI: 10.1001/jama.2013.242978 External Web Site Policy
  196. Fan R, Lee A, Lu Z, Liu A, Troendle JF, Mills JL. Association analysis of complex diseases using triads, parent-child dyads and singleton monads. BMC Genetics 2013 Sep 4; 14:78. PMID: 24007308. PMCID: PMC3844511. DOI: 10.1186/1471-2156-14-78 External Web Site Policy
  197. Fan R, Wang Y, Mills JL, Wilson AF, Bailey-Wilson JE, Xiong M. Functional linear models for association analysis of quantitative traits. Genet Epidemiol 2013 Nov; 37(7):726-742. PMID: 24130119. PMCID: PMC4163942. DOI: 10.1002/gepi.21757 External Web Site Policy
  198. Li Q, Xiong W, Chen JB, Zheng G, Li Z, Mills JL, Liu A. A robust test for quantitative trait analysis with model uncertainty in genetic association studies. Statistics and Its Interface 2014 Jan 1; 7:61-68.
  199. Molloy AM, Einri CN, Jain D, Laird E, Fan R, Wang Y, Scott JM, Shane B, Brody LC, Kirke PN, Mills JL. Is low iron status a risk factor for neural tube defects? Birth Defects Res A Clin Mol Teratol 2014 Feb; 100(2):100-106. PMID: 24535840. PMCID: PMC4018583. DOI: 10.1002/bdra.23223 External Web Site Policy
  200. Bao W, Tobias DK, Bowers K, Chavarro J, Vaag A, Grunnet LG, StrØm M, Mills J, Liu A, Kiely M, Zhang C. Physical activity and sedentary behaviors associated with risk of progression from gestational diabetes mellitus to type 2 diabetes mellitus: a prospective cohort study. JAMA Intern Med 2014 Jul;174(7):1047-1055. PMID: 24841449. PMCID: PMC4209161. DOI: 10.1001/jamainternmed.2014.1795 External Web Site Policy
  201. International League Against Epilepsy Consortium on Complex Epilepsies (Anney RJ, Avbersek A, Balding D, Baum L, Becker F, Berkovic SF, Bradfield JP, Brody LC, Buono RJ, Catarino CB, Cavalleri GL, Cherny SS, Chinthapalli K, Coffey AJ, Compston A, Cossette P, de Haan GJ, De Jonghe P, de Kovel CG, Delanty N, Depondt C, Dlugos DJ, Doherty CP, Elger CE, Ferraro TN, Feucht M, Franke A, French J, Gaus V, Goldstein DB, Gui H, Guo Y, Hakonarson H, Hallmann K, Heinzen EL, Helbig I, Hjalgrim H, Jackson M, Jamnadas-Khoda J, Janz D, Johnson MR, Kälviäinen R, Kantanen AM, Kasperavičiūte D, Trenite DK, Koeleman BP, Kunz WS, Kwan P, Lau YL, Lehesjoki AE, Lerche H, Leu C, Lieb W, Lindhout D, Lo W, Lowenstein DH, Malovini A, Marson AG, McCormack M, Mills JL, Moerzinger M, MØller RS, Molloy AM, Muhle H, Newton M, Ng PW, Nöthen MM, Nürnberg P, O'Brien TJ, Oliver KL, Palotie A, Pangilinan F, Pernhorst K, Petrovski S, Privitera M, Radtke R, Reif PS, Rosenow F, Ruppert AK, Sander T, Scattergood T, Schachter S, Schankin C, Scheffer IE, Schmitz B, Schoch S, Sham PC, Sisodiya S, Smith DF, Smith PE, Speed D, Sperling MR, Steffens M, Stephani U, Striano P, Stroink H, Surges R, Tan KM, Thomas GN, Todaro M, Tostevin A, Tozzi R, Trucks H, Visscher F, von Spiczak S, Walley NM, Weber YG, Wei Z, Whelan C, Yang W, Zara F, Zimprich F). Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies. Lancet Neurol 2014 Sep; 13(9):893-903. PMID: 25087078. PMCID: PMC4189926. DOI: 10.1016/S1474-4422(14)70171-1 External Web Site Policy
  202. Pangilinan F, Molloy AM, Mills JL, Troendle JF, Parle-McDermott A, Kay DM, Browne ML, McGrath EC, Abaan HO, Sutton M, Kirke PN, Caggana M, Shane B, Scott JM, Brody LC. Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects. BMC Med Genet 2014 Oct 8; 15:102. PMID: 25293959. PMCID: PMC4411759. DOI: 10.1186/s12881-014-0102-9 External Web Site Policy
  203. Mills JL, Fan R, Brody LC, Liu A, Ueland PM, Wang Y, Kirke PN, Shane B, Molloy AM. Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects. Am J Clin Nutr 2014 Oct; 100(4):1069-1074. PMID: 25240073. PMCID: PMC4163794. DOI: 10.3945/ajcn.113.079319 External Web Site Policy
  204. Zhang C, Hu FB, Olsen SF, Vaag A, Gore-Langton R, Chavarro JE, Bao W, Yeung E, Bowers K, Grunnet LG, Sherman S, Kiely M, StrØm M, Hansen S, Liu A, Mills J, Fan R; DWH study team. Rationale, design, and method of the Diabetes & Women's Health Study - a study of long-term health implications of glucose intolerance in pregnancy and their determinants. Acta Obstet Gynecol Scand 2014 Nov; 93(11):1123-1130. PMID: 24828694. PMCID: PMC4205761. DOI: 10.1111/aogs.12425 External Web Site Policy
  205. Ma Q, Ozel AB, Ramdas S, McGee B, Khoriaty R, Siemieniak D, Li HD, Guan Y, Brody LC, Mills JL, Molloy AM, Ginsburg D, Li JZ, Desch KC. Genetic variants in PLG, LPA and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels. Blood 2014 Nov 13; 124(20):3155-3164. PMID: 25208887. PMCID: PMC4231423. DOI: 10.1182/blood-2014-03-560086 External Web Site Policy
  206. Fan R, Wang Y, Mills JL, Carter TC, Lobach I, Wilson AF, Bailey-Wilson JE, Weeks DE, Xiong M. Generalized functional linear models for gene-based case-control association studies. Genet Epidemiol 2014 Nov; 38(7):622-637. PMID: 25203683. PMCID: PMC4189986. DOI: 10.1002/gepi.21840 External Web Site Policy
  207. Yeung EH, Liu A, Mills JL, Zhang C, Männistö T, Lu Z, Tsai MY, Mendola P. Increased Levels of Copeptin Before Clinical Diagnosis of Preeclampsia. Hypertension 2014 Dec; 64(6):1362-1367. PMID: 25225209. DOI: 10.1161/HYPERTENSIONAHA.114.03762 External Web Site Policy
  208. Deac OM, Mills JL, Shane B, Midttun Ø, Ueland PM, Brosnan JT, Brosnan ME, Laird E, Gibney ER, Fan R, Wang Y, Brody LC, Molloy AM. Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults. J Nutr 2015 Apr; 145(4):701-707. PMID: 25833774. PMCID: PMC4381767. DOI: 10.3945/jn.114.203091 External Web Site Policy
  209. Wang Y, Liu A, Mills JL, Boehnke M, Wilson AF, Bailey-Wilson JE, Xiong M, Wu CO, Fan R. Pleiotropy analysis of quantitative traits at gene level by multivariate functional linear models. Genet Epidemiol 2015 May; 39(4):259-275. PMID: 25809955. PMCID: PMC4443751. DOI: 10.1002/gepi.21895 External Web Site Policy
  210. Rigler SL, Kay DM, Sicko RJ, Fan R, Liu A, Caggana M, Browne ML, Druschel CM, Romitti PA, Brody LC, Mills JL. Novel copy-number variants in a population-based investigation of classic heterotaxy. Genet Med 2015 May; 17(5):348-357. PMID: 25232849. DOI: 10.1038/gim.2014.112 External Web Site Policy
  211. Bao W, Yeung E, Tobias DK, Hu FB, Vaag AA, Chavarro JE, Mills JL, Grunnet LG, Bowers K, Ley SH, Kiely M, Olsen SF, Zhang C. Long-term risk of type 2 diabetes mellitus in relation to BMI and weight change among women with a history of gestational diabetes mellitus: a prospective cohort study. Diabetologia 2015 Jun; 58(6):1212-1219. PMID: 25796371. PMCID: PMC4629783. DOI: 10.1007/s00125-015-3537-4 External Web Site Policy
  212. Carter TC, Pangilinan F, Molloy AM, Fan R, Wang Y, Shane B, Gibney ER, Midttun Ø, Ueland PM, Cropp CD, Kim Y, Wilson AF, Bailey-Wilson JE, Brody LC, Mills JL. Common Variants at Putative Regulatory Sites of the Tissue Nonspecific Alkaline Phosphatase Gene Influence Circulating Pyridoxal 5'-Phosphate Concentration in Healthy Adults. J Nutr 2015 Jul; 145(7):1386-1393. PMID: 25972531. PMCID: PMC4478949. DOI: 10.3945/jn.114.208769 External Web Site Policy
  213. Bailey LB, Stover PJ, McNulty H, Fenech MF, Gregory JF 3rd, Mills JL, Pfeiffer CM, Fazili Z, Zhang M, Ueland PM, Molloy AM, Caudill MA, Shane B, Berry RJ, Bailey RL, Hausman DB, Raghavan R, Raiten DJ. Biomarkers of Nutrition for Development-Folate Review. J Nutr 2015 Jul; 145(7):1636S-1680S. PMID: 26451605. PMCID: PMC4478945. DOI: 10.3945/jn.114.206599 External Web Site Policy
  214. Bailey RL, Looker AC, Lu Z, Fan R, Eicher-Miller HA, Fakhouri TH, Gahche JJ, Weaver CM, Mills JL. B-vitamin status and bone mineral density and risk of lumbar osteoporosis in older females in the United States. Am J Clin Nutr 2015 Sep; 102(3):687-694. PMID: 26224297. PMCID: PMC4548174. DOI: 10.3945/ajcn.115.108787 External Web Site Policy
  215. Ozaki M, Molloy AM, Mills JL, Fan R, Wang Y, Gibney ER, Shane B, Brody LC, Parle-McDermott A. The Dihydrofolate Reductase 19 bp Polymorphism Is Not Associated with Biomarkers of Folate Status in Healthy Young Adults, Irrespective of Folic Acid Intake. J Nutr 2015 Oct;145(10):2207-2211. PMID: 26269242. PMCID: PMC4580961. DOI: 10.3945/jn.115.216101 External Web Site Policy
  216. Mills JL, Dimopoulos A. Authors' reply to Smith and colleagues. BMJ 2016 Feb 16; 352:i746. PMID: 26882916
  217. Szymczak S, Holzinger E, Dasgupta A, Malley JD, Molloy AM, Mills JL, Brody LC, Stambolian D, Bailey-Wilson JE. r2VIM: A new variable selection method for random forests in genome-wide association studies. BioData Min 2016 Feb 1; 9:7. PMID: 26839594. PMCID: PMC4736152. DOI: 10.1186/s13040-016-0087-3 External Web Site Policy
  218. Boghossian NS, Sicko RJ, Kay DM, Rigler SL, Caggana M, Tsai MY, Yeung EH, Pankratz N, Cole BR, Druschel CM, Romitti PA, Browne ML, Fan R, Liu A, Brody LC, Mills JL. Rare copy number variants implicated in posterior urethral valves. Am J Med Genet A. 2016 Mar: 170(3):622-633. PMID: 26663319. DOI: 10.1002/ajmg.a.37493 External Web Site Policy
  219. VanderMeer JE, Carter TC, Pangilinan F, Mitchell A, Kurnat-Thoma E, Kirke PN, Troendle JF, Molloy AM, Munger RG, Feldkamp ML, Mansilla MA, Mills JL, Murray JC, Brody LC. Evaluation of proton-coupled folate transporter (SLC46A1) polymorphisms as risk factors for neural tube defects and oral clefts. Am J Med Genet A. 2016 Apr; 170A(4):1007-1016. PMID: 26789141. DOI: 10.1002/ajmg.a.37539 External Web Site Policy
  220. Molloy AM, Pangilinan F, Mills JL, Shane B, O'Neill MB, McGaughey DM, Abaan HO, Ueland PM, McNulty H, Ward M, Strain JJ, Cunningham C, Casey M, Cropp CD, Kim Y, Bailey-Wilson JE, Wilson AF, Brody LC . A Common Polymorphism in HIBCH Influences Methylmalonic Acid Concentrations in Blood Independently of Cobalamin. Am J Hum Genet. 2016 May 5; 98(5):869-882. PMID: 27132595. PMCID: PMC4863564. DOI: 10.1016/j.ajhg.2016.03.005 External Web Site Policy
  221. Li S, Zhu Y, Chavarro JE, Bao W, Tobias DK, Ley SH, Forman JP, Liu A, Mills J, Bowers K, StrØm M, Hansen S, Hu FB, Zhang C. Healthful dietary patterns and the risk of hypertension among women with a history of gestational diabetes: A prospective cohort study. Hypertension 2016 Jun; 67(6):1157-1165. PMID: 27091899. PMCID: PMC4865422. DOI: 10.1161/HYPERTENSIONAHA.115.06747 External Web Site Policy
  222. Mills JL, Dimopoulos A, Bailey RL. What is standing in the way of complete prevention of folate preventable neural tube defects? Birth Defects Res A Clin Mol Teratol 2016 Jul; 106(7):517-519. PMID: 27418028. PMCID: PMC4948865. DOI: 10.1002/bdra.23518 External Web Site Policy
  223. Ozel AB, McGee B, Siemieniak D, Jacobi PM, Haberichter SL, Brody LC, Mills JL, Molloy AM, Ginsburg D, Li JZ, Desch KC. Genome-wide studies of von Willebrand factor propeptide identify loci contributing to variation in propeptide levels and von Willebrand factor clearance. J Thromb Haemost 2016 Sep; 14(9):1888-1898. PMID: 27359253. PMCID: PMC5035595. DOI: 10.1111/jth.13401 External Web Site Policy
  224. Deac OM, Mills JL, Gardiner CM, Shane B, Quinn L, Midttun Ø, McCann A, Meyer K, Ueland PM, Fan R, Lu Z, Brody LC, Molloy AM. Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults. J Nutr 2016 Sep; 146(9):1801-1806. PMID: 27489009. PMCID: PMC4997280. DOI: 10.3945/jn.116.230698 External Web Site Policy
  225. Sicko RJ, Browne ML, Rigler SL, Druschel CM, Liu G, Fan R, Romitti PA, Caggana M, Kay DM, Brody LC, Mills JL. Genetic Variants in Isolated Ebstein Anomaly Implicated in Myocardial Development Pathways. PLoS One 2016 Oct 27; 11(10):e0165174. PMID: 27788187. PMCID: PMC5082909. DOI: 10.1371/journal.pone.0165174 External Web Site Policy
  226. Fan R, Chiu CY, Jung J, Weeks DE, Wilson AF, Bailey-Wilson JE, Amos CI, Chen Z, Mills JL, Xiong M. A Comparison Study of Fixed and Mixed Effect Models for Gene Level Association Studies of Complex Traits. Genet Epidemiol. 2016 Dec; 40(8):702-721. PMID: 27374056. DOI: 10.1002/gepi.21984 External Web Site Policy
  227. Hagen EM, Sicko RJ, Kay DM, Rigler SL, Dimopoulos A, Ahmad S, Doleman MH, Fan R, Romitti PA, Browne ML, Caggana M, Brody LC, Shaw GM, Jelliffe-Pawlowski LL, Mills JL. Copy-number variant analysis of classic heterotaxy highlights the importance of body patterning pathways. Hum Genet 2016 Dec; 135(12):1355-1364. PMID: 27637763. PMCID: PMC5065782. DOI: 10.1007/s00439-016-1727-x External Web Site Policy
  228. Chiu CY, Jung J, Wang Y, Weeks DE, Wilson AF, Bailey-Wilson JE, Amos CI, Mills JL, Boehnke M, Xiong M, Fan R. A comparison study of multivariate fixed models and Gene Association with Multiple Traits (GAMuT) for next-generation sequencing. Genet Epidemiol 2017 Jan; 41(1):18-34. PMID: 27917525. PMCID: PMC5154843. DOI: 10.1002/gepi.22014 External Web Site Policy
  229. Dimopoulos A, Sicko RJ, Kay DM, Rigler SL, Druschel CM, Caggana M, Browne ML, Fan R, Romitti PA, Brody LC, Mills JL. Rare copy number variants in a population-based investigation of hypoplastic right heart syndrome. Birth Defects Res 2017 Jan 20; 109(1):8-15. PMID: 28009100. PMCID: PMC5388571. DOI: 10.1002/bdra.23586
  230. Mendola P, Ghassabian A, Mills JL, Zhang C, Tsai MY, Liu A, Yeung EH. Retinol-Binding Protein 4 and Lipids Prospectively Measured During Early to Mid-Pregnancy in Relation to Preeclampsia and Preterm Birth Risk. Am J Hypertens 2017 Feb 16. PMID: 28338737. DOI: 10.1093/ajh/hpx020 External Web Site Policy
  231. Dimopoulos A, Sicko RJ, Kay DM, Rigler SL, Fan R, Romitti PA, Browne ML, Druschel CM, Caggana M, Brody LC, Mills JL. Copy number variants in a population-based investigation of Klippel-Trenaunay syndrome. Am J Med Genet A 2017 Feb. PMID: 27901321. DOI: 10.1002/ajmg.a.37868 External Web Site Policy
  232. Chiu CY, Jung J, Chen W, Weeks DE, Ren H, Boehnke M, Amos CI, Liu A, Mills JL, Ting Lee ML, Xiong M, Fan R. Meta-analysis of quantitative pleiotropic traits for next-generation sequencing with multivariate functional linear models. Eur J Hum Genet 2017 Feb; 25(3):350-359. PMID: 28000696. PMCID: PMC5315507. DOI: 10.1038/ejhg.2016.170 External Web Site Policy
  233. Faucz FR, Tirosh A, Tatsi C, Berthon A, Hernández-Ramírez LC, Settas N, Angelousi A, Correa R, Papadakis GZ, Chittiboina P, Quezado M, Pankratz N, Lane J, Dimopoulos A, Mills JL, Lodish M, Stratakis CA. Somatic USP8 gene mutations are a common cause of pediatric Cushing disease. J Clin Endocrinol Metab 2017 May 12. PMID: 28505279. DOI: 10.1210/jc.2017-00161
  234. Carter TC, Sicko RJ, Kay DM, Browne ML, Romitti PA, Edmunds ZL, Liu A, Fan R, Druschel CM, Caggana M, Brody LC, Mills JL. Copy-number variants and candidate gene mutations in isolated split hand/foot malformation. J Hum Genet 2017 May 25. PMID: 28539665. DOI: 10.1038/jhg.2017.56.
  235. Zhang W, Yang L, Tang LL, Liu A, Mills JL, Sun Y, Li Q. GATE: an efficient procedure in study of pleiotropic genetic associations. BMC Genomics 2017 Jul 21; 18(1):552. PMID: 28732532. PMCID: PMC5521155. DOI: 10.1186/s12864-017-3928-7 External Web Site Policy
  236. Hernández-Ramírez LC, Gam R, Valdés N, Lodish MB, Pankratz N, Balsalobre A, Gauthier Y, Faucz FR, Trivellin G, Chittiboina P, Lane J, Kay DM, Dimopoulos A, Gaillard S, Neou M, Bertherat J, Assié G, Villa C, Mills JL, Drouin J, Stratakis CA. Loss-of-function mutations in the CABLES1 gene are a novel cause of Cushing's disease. J Clin Endocrinol Metab 2017 Aug; 24(8):379-392. PMID: 28533356. PMCID: PMC5510591. DOI: 10.1530/ERC-17-0131.

Non-refereed Manuscripts

  1. Mills JL, Bongiovanni AM. Effect of prenatal estrogen exposure on male genitalia. Pediatrics 1978 Dec; 62(6 Pt 2):1160-1165. PMID: 724353
  2. O'Sullivan J, Harris MI, Mills JL. Diabetes in pregnancy. In: Diabetes in America. Diabetes Data Compiled 1984. Department of Health and Human Services. NIH Publication No. 85-1468, Chapter XX, 1985, pp. 1-17.
  3. Mills JL, O'Sullivan J. Infants of diabetic mothers. In: Diabetes in America. Diabetes Data Compiled 1984. Department of Health and Human Services. NIH Publication No. 85-1468, Chapter XXI, 1985, pp. 1-19.
  4. Report of the Second International Workshop - Conference on Gestational Diabetes. Summary and recommendations IV. Prognostic considerations. Diabetes 1986; 34:126 (suppl. 2).
  5. Mills JL. Reporting provocative results: Can we publish "hot" papers without getting burned? (Commentary). JAMA 1987 Dec 18; 258(23):3428-3429. PMID: 3682142
  6. Mills JL. Commentary. Diabetes Spectrum: From Research to Practice 1990; 3:165-166.
  7. Mills JL. Fertility drugs and neural tube defects: Why can't we make up our minds? Teratol 1990 Dec; 42(6):595-596. (Invited Commentary incorrectly listed as Letter). PMID: 2087680. DOI: 10.1002/tera.1420420603 External Web Site Policy
  8. Mills JL. Commentary. Diabetes Spectrum: From Research to Practice 4:218, 1991.
  9. Mills JL. Protecting the embryo from x-rated drugs. N Engl J Med 1995 Jul 13; 333(2):124-125. PMID: 7777019. DOI: 10.1056/NEJM199507133330211 External Web Site Policy
  10. Mills JL. Cocaine, smoking, and spontaneous abortion. N Engl J Med 1999 Feb 4; 340(5):380-1. PMID: 9929530. DOI: 10.1056/NEJM199902043400509 External Web Site Policy
  11. Mills JL. Folate and oral clefts: where do we go from here? New directions in oral clefts research. Teratol 1999 Nov; 60(5):251-2. PMID: 10525200. DOI: 10.1002/(SICI)1096-9926(199911)60:5<251::AID-TERA3>3.0.CO;2-# External Web Site Policy
  12. Mills JL, England L. Food fortification to prevent neural tube defects: is it working? JAMA 2001 Jun 20; 285(23):3022-3. PMID: 11410102
  13. Statement of the Public Affairs Committee of the Teratology Society on the Importance of Smoking Cessation During Pregnancy [contributing author and committee member]. Jane Adams, lead author. Birth Defects Res A Clin Mol Teratol 2003 Nov; 67(11):895-9. PMID: 14745924. DOI: 10.1002/bdra.10140 External Web Site Policy
  14. The Public Affairs Committee of the Teratology Society [Member of the Committee]. Causation in teratology-related litigation. Birth Defects Res A Clin Mol Teratol 2005 Jun; 73(6):421-3. PMID: 15880786. DOI: 10.1002/bdra.20139 External Web Site Policy
  15. Scialli AR, Public Affairs Committee of the Teratology Society [Member of the Committee]. Teratology Public Affairs Committee Position Paper: Maternal Obesity and Pregnancy. Birth Defects ResA Clin Mol Teratol 2006 Feb; 76(2):73-7. PMID: 16463272. DOI: 10.1002/bdra.20236 External Web Site Policy
  16. Mills JL. Depressing observations on the use of selective serotonin-reuptake inhibitors during pregnancy. N Engl J Med 2006 Feb 9; 354(6):636-8. PMID: 16467553. DOI: 10.1056/NEJMe058311 External Web Site Policy
  17. Molloy AM, Kirke PN, Brody LC, Scott JM, Mills JL. Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. Food and Nutrition Bulletin 2008 Jun; 29(2 Suppl):S101-11. PMID: 18709885. DOI: 10.1177/15648265080292S114 External Web Site Policy
  18. Mills JL, Carter TC. Invited commentary: Preventing neural tube defects and more via food fortification? Am J Epidemiol 2009 Jan 1; 169(1):18-21; discussion 22-3. PMID: 18953060. PMCID: PMC2720707. DOI: 10.1093/aje/kwn329 External Web Site Policy
  19. Mills JL, Carter TC. Acyclovir exposure and birth defects: an important advance, but more are needed. JAMA 2010 Aug 25; 304(8):905-6. PMID: 20736478. PMCID: PMC4158607. DOI: 10.1001/jama.2010.1214 External Web Site Policy
  20. Mills JL. Malformations in infants of diabetic mothers. Teratology 25: 385-94. 1982. Birth Defects Res A Clin Mol Teratol. 2010;88:769-78 [Selected “Classic Paper” celebrating 50th anniversary of the Teratology Society]
  21. Mills JL. Preventing folate-related neural tube defects: Problem solved, or not? Birth Defects Res A Clin Mol Teratol 2015 Jun; 103(6):469-70. PMID: 25884960. DOI: 10.1002/bdra.23380 External Web Site Policy
  22. Mills JL, Dimopoulos A. Folic acid fortification for Europe? BMJ 2015 Nov 24; 351:h6198. PMID: 26602789
  23. Mills JL. Strategies for Preventing Folate-Related Neural Tube Defects: Supplements, Fortified Foods, or Both? JAMA 2017 Jan 10; 317(2):144-5. PMID: 28097344. DOI: 10.1001/jama.2016.19894 External Web Site Policy

Invited Book Chapters

  1. Koppe J, Smorenberg-Schoorl M, van den Berg-Loonen E, Mills JL. Diabetes, congenital malformations and HLA types. In: Stern L, Bard H, and Friis-Hansen B (eds.). Intensive Care in the Newborn, vol. 4. Masson Publishing, New York, 1983, pp. 15-18.
  2. Workgroup - National Diabetes Advisory Board. Pregnancy and fetal malformations. In: Progress and Promise in Diabetes Research: Report of the Second National Diabetes Research Conference. National Diabetes Advisory Board. Department of Health and Human Services. NIH Publication No. 84-661, 1984, pp. 87-95.
  3. Simpson JL, Mills JL. Methodologic problems in determining fetal loss rates: Relevance to chorionic villi sampling. In: Fraccaro M, Simoni G, Brambati B (eds.). First Trimester Fetal Diagnosis. Springer-Verlag, New York, 1985, pp. 321-333.
  4. Mills JL. Endocrinology of premature thelarche. In: John McLachlan (ed.). Estrogens in the Environment II: Influences on Development. Elsevier, New York, 1985, pp. 412-427.
  5. Cordero JF, Haddock L, Lebron G, Martinez R, Freni-Titulaer LW, Mills JL. Premature thelarche in Puerto Rico: Design of a case-control study. In: John McLachlan (ed.). Estrogens in the Environment II. Elsevier, New York, 1985, pp. 380-395.
  6. Simpson JL, Mills JL. Methodologic problems in determining fetal loss rates. In: Brambati B, Simoni G, Fabro (eds.). Chorionic Villus Sampling: Fetal Diagnosis of Genetic Diseases in the First Trimester. Marcel Dekkar, New York, 1986, pp. 227-257.
  7. Rotter J, Mills JL. Diabetes mellitus. In: Berini RY, Kahn E (eds.). Clinical Genetics Handbook. Medical Economics, Oradell, New Jersey, 1986, pp. 227-234.
  8. Mills JL, Withiam M. Diabetes, pregnancy, and malformations: An epidemiologic perspective. In: Jovanovic L, Peterson CM, Fuhrmann K (eds.). Diabetes and Pregnancy: Teratology, Toxicity and Treatment. Praeger, New York, 1986, pp. 3-14.
  9. Jovanovic L, Mills JL, Peterson CM. Rationale for the use of human insulin in pregnancy. In: Jovanovic L, Peterson CM, Fuhrmann K (eds.). Diabetes and Pregnancy: Teratology, Toxicity and Treatment. Praeger, New York, 1986, pp. 157-167.
  10. Mills JL, Graubard BI. La controversia sugli effetti del bere moderatamente durante la gravidanza. In: Pachi A, Astrei G (eds.). Tutela Della Salute Della Gestante e del Concepito. Acta Medica, Rome, 1986, pp. 123-128.
  11. Simpson JL, Mills JL, Knopp RH, Jovanovic L, Metzger BE, NICHD-DIEP. Congenital anomalies and type I diabetes mellitus. Proceedings of 12th Meeting International Federation Obstetrics and Gynecology. Rio de Janeiro, 1988, J.A. Pinotti, P. Belfort, eds., Parthenon, Lancaster, U.K.
  12. Mills JL. Spermicides and Birth Defects. In: Phantom Risk: Scientific Inference and the Law, Foster KR, Bernstein DE, Huber PW (eds.). MIT Press, 1993, pp. 87-100.
  13. Simpson JL, Mills JL, Ober C, Holmes L, Knopp R, Jovanovic-Peterson L, Metzger B, Aarons J, Conley M, Reed G, and the NICHD-DIEP. Is there a genetic basis for diabetic teratogenicity? In: The Current Status of Gynaecology and Obstetric Series, Proceedings of the XIIIth World Congress of Gynaecology and Obstetrics, Singapore, September 1991, Volume 2: Fetal Physiology and Pathology, Teoh E-S, Ratnam SS, Macnaughton M (eds.). Parthenon Publishing Group, 1993, pp. 119-125.
  14. Simpson JL, Mills JL, Rhoads G, Cunningham G. Genetic heterogeneity and neural tube defects: relevance to folate-responsiveness. Care, Concern and Cure. Proceedings of the XIII European Congress on Perinatal Medicine, Amsterdam, May 1992, Parthenon Publ.
  15. Mills JL. Birth defects. Congressional Record 1996; 141:E1743-4.
  16. Klebanoff MA, Read J, Mills JL, Shiono PH. Neonatal vitamin K administration and cancer during childhood. In: Sutor A, Hathaway W, eds. Proceedings of the International Symposium on Vitamin K in Infancy. Stuttgart, Germany: 1995, 303-313.
  17. Carson SA, Mills JL, Metzger B, Jovanovic-Peterson L, Knopp R, Conley M, Simpson JL. How significant are non-genetic factors in spontaneous abortions? In: New Horizons in Reproductive Medicine, Parthenon Publishing Group, New York, C. Coutifaris and L. Mastroianni, eds., 1997, pp 501-506.
  18. Molloy AM, Ramsbottom D, McPartlin J, Whitehead AS, Weir DG, Scott JM, Kirke PN, Burke H, Daly S, Mills JL, Conley M. 5,10-Methylenetetrahydrofolate reductases C677T genotypes and folate related risk factors for neural tube defects. In:W. Pfleiderer, H. Rokos, eds. Chemistry and Biology of Pteridines and Folates 1997: Proceedings of the Eleventh International Symposium on Pteridines and Folates, Berchtesgaden, Germany, June 15-20, 1997. Berlin: Blackwell Science; 1997: 291-296.