Curriculum Vitae

Aiyi Liu, PhD

Work Address

Biostatistics and Bioinformatics Branch
Division of Intramural Population Health Research
Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, 6100 Executive Blvd., Room 7B05D, Rockville, MD 20892

Telephones (301) 435-6952 (office)     (301) 825-2245 (cell)
Emails liua@mail.nih.gov   aiyiliu65@gmail.com   aiyiliu@gwu.edu

Education and Training

B.S. in Mathematics (Statistics Major), 1986; M.S. in Statistics, 1988; Department of Mathematics, University of Science and Technology of China, Hefei, Anhui, China

Ph.D. in Statistics, 1997, Department of Statistics, University of Rochester, Rochester, NY, U.S.A.

Postdoctoral Research Fellow, 1997-1999, Department of Biostatistics and Epidemiology, St. Jude Children's Research Hospital, Memphis, TN, U.S.A.

Current Position

2007-Present

Senior Investigator (with Tenure) Biostatistics and Bioinformatics Branch
Division of Intramural Population Health Research
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health

Past Academic/Research Appointment

Investigator (Tenure Track), 2002-2007, Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health

Assistant Professor of Biostatistics (Tenure Track), 1999-2002, Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University; Faculty member, 1988-1993, Department of Mathematics, University of Science and Technology of China

Membership in Professional Societies

American Statistical Association, International Biometric Society (ENAR), International Chinese Statistical Association, International Indian Statistical Association, International Statistical Institute, Institute of Mathematical Statistics, and Korean International Statistical Society

Honors and Awards

Jiuzhang Mathematical Prize, University of Science and Technology of China, 1991

Graduate Fellowships, University of Rochester, 1993-1997
Time-Off Award in Recognition and Appreciation of Special Act or Service, NICHD, NIH, 2002

Elected member, International Statistical Institute, 2006

National Institutes of Health Merit Award, 2007, 2009

Fellow, American Statistical Association, 2011 (For major contributions to sequential methods, especially in the area of statistical inference following sequential tests, for contributions to statistical research in diagnostic medicine, and for innovative applications of statistics to biomedical research)

National Institutes of Health Director's Award, 2013, 2015

Professional Service

Associate Editor, Clinical Trials: Journal of the Society for Clinical Trials, 2014-Present

Member, Committee on Award of an Outstanding Statistical Application, the American Statistical Association (ASA), 2011-Present

Chair, Program Committee and Executive Committee, International Chinese Statistical Association 2013 Applied Statistics Symposium

Member, Program Committee, International Chinese Statistical Association 2011 Applied Statistics Symposium

Associate Editor, Journal of Statistical Planning and Inference, 2009-2012.

Member, Program Committee, International Chinese Statistical Association 2005 Applied Statistics Symposium

Member, Board of Directors, International Chinese Statistical Association, 2007-2009

Short course instructor on “Sequential Statistical Methods in the Design and Analysis of Clinical Trials”, at The 15th International Conference on Interdisciplinary Mathematical and Statistical Techniques, Shanghai, China, June 2007

Guest Editor for “Mathematical and Statistical Methods for Diagnoses and Therapies”. Philosophical Transaction of the Royal Society A, Number 1874, Volume 366, July 2008

Short course instructor on “Evaluation of the Performance of Diagnostic Tests and Biomarkers Using ROC Analysis”, Society for Clinical Trials (SCT) 35th Annual Meeting, Philadelphia, PA, May 2014.

Member, Program Committee, International Chinese Statistical Association 2015 Applied Statistics Symposium

Peer referee for American Journal of Epidemiology, Biometrics, Biometrika, Biostatistics, Cancer Research, Communications in Statistics, Controlled Clinical Trials, Computational Statistics & Data Analysis, Epidemiology, Journal of Biopharmaceutical Statistics, Journal of Statistical Planning and Inference, Journal of the American Statistical Association, Journal of Multivariate Analysis, Medical and Pediatric Oncology, Pharmacotherapy, Statistics in Biosciences, Statistics in Biopharmaceutical Research, Statistics in Medicine, Statistics and Probability Letters, Statistical Science, Statistica Sinica

Research Interest

General statistical theory and methods
Sequential and adaptive methods in clinical trials and biomedical research
Multivariate data analysis and related topics
Statistical methodology for diagnostic biomarkers (ROC curve analysis; methods for pooled biospecimens; evaluation of measurement errors; limit of detection and left truncation)
Semiparametric and nonparametric methods for multidimensional data
Genome-wide association studies
Group testing methodology

Teaching, Training and Mentoring

Teaching various undergraduate and graduate statistics courses, including Statistics for Biological Sciences, Linear Models and its Applications, Regression Analysis. Department of Mathematics, University of Science and Technology of China, August 1988-July 1993

Teaching Assistant in various undergraduate statistics courses. University of Rochester, Department of Statistics, September 1993-August 1997

Teaching in the MS program of biostatistics in the Department of Biostatistics and Epidemiology of Georgetown University Medical Center, participating lecture series for staff and postdoctoral fellows in the Department of Oncology and Lombardi Cancer Center, March 1999-February 2002.

Teaching Applied Biostatistics (19 students, 4 classes), January–February 2002

Teaching “Applied Multivariate Statistical Analysis” (Stat6215, graduate level), Fall 2011, Spring 2015, Department of Statistics, George Washington University

Teaching “Clinical Trials” (STAT6289-13, graduate level), Spring 2012, Fall 2015, Spring 2016, Department of Statistics, George Washington University

Teaching “Regression Analysis” (STAT2118, graduate level), Spring 2013, Fall 2013, Department of Statistics, George Washington University

Co-Mentor (with Enrique Schisterman) to summer students at NICHD: Eric Teoh (University of Alabama), 2002; Howard Bondell (Rutgers University), Neil Perkins (American University), 2003

Mentor to summer interns at NICHD: Yan Zhu (University of Virginia), 2003; Helen Guo (Thomas Jefferson High School for Science and Technology), 2004; Elizabeth Schofield Dahlquist (University of South Florida), 2005; Ekaterina Eliseeva (University of Chicago), 2006; Helen Guo (University o2f Virginia), 2007; Xiaoshu Feng (University of Maryland), 2008, Angel Davalos (University of Texas-El Paso), 2009; Robert Ashmead (The Ohio State University), 2011; Le Chen (Gallaudet University) 2013; Gregory Haber (University of Maryland Baltimore County), 2014;

Mentor to postdoctoral fellows at NICHD: Chengqing Wu (University of Science and Technology of China), October 2003-October 2007; Albert Vexler (Hebrew University), June 2004-June 2007; Catherine Chunling Liu (University of Hong Kong), October 2008-July 2010; Jared Foster (University of Michigan), August 2013-August 2015; Wondwosen Kassahun Yimer (Hasselt University, Belgium), August 2015-August 2017.

Ph.D. thesis advisor (with Professor Zhaohai Li) to Yu Shu, Department of Statistics, George Washington University.

Ph.D. thesis advisor (with Professor Zhaohai Li) to Mei Jin, Department of Statistics, George Washington University

Ph.D. thesis advisor (with Professor Zhaohai Li) to Xian Sun, Department of Statistics, George Washington University

Ph.D. thesis advisor (with Professor Zhaohai Li) to Xiaoyu Cai, Department of Statistics, George Washington University

Ph.D. thesis advisor (with Professor Daniel Q. Naiman) to Jiang Hu, Department of Applied Mathematics and Statistics, the Johns Hopkins University.

Services at NIH

Committee on Division of Intramural Population Health Research Retreat, 2002

Search Committee for Staff Scientist, Division of Intramural Population Health Research, 2003

Ph.D. Thesis Committee for Jiaquan Fan, Department of Statistics, George Washington University, March 2004

Ph.D. Thesis Committee for Dennis Buckman, Department of Statistics, George Washington University, June 2005

Judge for the Fellows Award for Research Excellence (FARE) 2005, Gene Expression Section

Search Committee for Statistician Staff Scientist– Facility Head Recruitment, Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 2005, 2006

Search Committee member for tenure-track/tenured investigator, Epidemiology Branch, Division of Intramural Population Health Research, 2006

Data Safety and Monitoring Board (DSMB) for “S.japonicum and Pregnancy Outcomes: A Randomized, Double Blind, Placebo Controlled Trial”, National Institute of Allergy and Infectious Diseases (NIAID), 2006-Present

Ad hoc Reviewer, National Institute on Aging Board of Scientific Counselors’ (BSC) Meeting, May, 2008

Member, Search Committee for Tenure-Track Investigators, Division of Intramural Population Health Research, 2009

Member, Search Committee for Tenure-Track/Tenure-Eligible Investigators, Division of Intramural Population Health Research, 2010

Member, Professional Development Committee, Division of Intramural Population Health Research, 2010

Member, Institutional Review Board (IRB), National Institute of Child Health and Human Development, 2011-Present

Member, Search Committee for Tenure-Track/Tenure-Eligible Investigators, Division of Intramural Population Health Research, 2012

Ad hoc Reviewer, National Institute on Aging Board of Scientific Counselors’ (BSC) Meeting, May, 2012

Member, Search Committee for Staff Scientist, Division of Intramural Population Health Research, 2013

Member, Mentoring Committee, Division of Intramural Population Health Research, 2013

Invited Presentations

“Secondary analysis following sequential clinical trials”. Western Tennessee Chapter of ASA, Memphis, TN, April 1998

“Sequential tests and estimates after overrunning”. Statistical Research Symposium in Honor of W. Jackson Hall’s 70th Birthday. University of Rochester, Rochester, NY, September 1999

“Molecular classification of stage I breast cancer using gene microarray technology”. International Chinese Statistical Association Applied Statistics Symposium, Piscataway, NJ, June 1999

“Sample size calculation for planning group sequential longitudinal trials”. CDER, Food and Drug Administration (FDA), Rockville, MD, March 2000

“Analyzing data from a sequential clinical trial”. Workshop on Current Advances in Interim Analysis and Design Modifications, CDER, Food and Drug Administration (FDA), Rockville, MD, September 2000

“Block principal component analysis with application to gene microarray data classification”. Office of Biostatistics Research, National Heart Lung and Blood Institute, April 2003

“Unbiased estimation following a group sequential test for distributions in the exponential family”. Department of Mathematics and Statistics, York University, Canada, November 2003

“Estimation following a multivariate group sequential test”. International Chinese Statistical Association Applied Statistics Symposium, San Diego, CA, June 2004

“On linear combinations of biomarkers to improve diagnostic accuracy”. Department of Epidemiology and Biostatistics, Medical University of South Carolina, September 2004

“On linear combinations of biomarkers to improve diagnostic accuracy”. Division of Cancer Epidemiology and Genetics, National Cancer Institute, January 2005

“Estimation following a group sequential test for distributions in the one-parameter exponential family”. Department of Mathematics, University of Maryland, February 2005

“Local maximization of linear combination of biomarkers to improve diagnostic accuracy”. International Chinese Statistical Association Applied Statistics Symposium, Washington, DC, June 2005

“Sequential evaluation of time varying, non-transient treatment effects in clinical trials”. International Biometric Society–WNAR/IMS Meeting, Fairbanks, Alaska, June 2005

“Estimation following a group sequential test for distributions in the one-parameter exponential family”. Department of Statistics, George Washington University, September 2005

“Estimating rates at the termination of a group sequential phase II trial”. Department of Statistics, University of Virginia, October 2005

“Estimation following a group sequential test for distributions in the one-parameter exponential family”. Department of Mathematics and Statistics, McMaster University, Canada, February 2006

“Non-parametric sequential testing of the area under the ROC curves”. International Biometric Society (ENAR) Spring Meeting, Tampa, FL, March 2006

“Multistage evaluation of measurement error in a reliability study”. International Chinese Statistical Association Applied Statistics Symposium, University of Connecticut, June 2006

“Multistage evaluation of measurement error in a reliability study”. Department of Applied Mathematics, Beijing University of Technology, China, July 2006

“Multistage evaluation of measurement error in a reliability study”. Department of Statistics, George Mason University, October 2006

“Multistage evaluation of measurement error in a reliability study”. Department of Biostatistics, Columbia University, February 2007

“An adaptive approach for bivariate phase II clinical trial designs”. The 15th International Conference on Interdisciplinary Mathematical and Statistical Techniques, Shanghai, China, June 2007

“Sequential methods for evaluation of medical tests” (Invited Plenary Speech). The 15th International Conference on Interdisciplinary Mathematical and Statistical Techniques, Shanghai, China, June 2007

“Sample Size for a logistic regression with a covariate subject to detection limit”. International Chinese Statistical Association Applied Statistics Symposium, Raleigh, NC, June 2007

“A two-stage procedure for selecting the best diagnostic biomarker with dichotomous outcomes”. The First International Workshop in Sequential Methodologies, Auburn, Alabama, July 2007

“An adaptive approach for testing two correlated proportions with application to bivariate phase II clinical trial designs”. Department of Biostatistics, State University of New York at Buffalo, September 2007

“Sequential evaluation of measurement error in a reliability study”. Department of Biostatistics and Computational Biology, University of Rochester, NY, November, 2007

“A threshold sample-enrichment approach in a clinical trial with heterogeneous subpopulations”. Division of Biostatistics, University of Maryland School of Medicine, Baltimore, MD, May 2008

“Sequential evaluation of measurement error in a reliability study”. International Chinese Statistical Association Applied Statistics Symposium, Piscataway, NJ, June 2008

“Two-stage procedures in statistical experiments and analysis”. Department of Mathematics and Statistics, University of South Alabama, Mobile, October 2008

“A threshold sample-enrichment approach in a clinical trial with heterogeneous subpopulations”. Symposium in Honor of Dr. Edmund Gehan, Georgetown University Medical Center, Washington, DC, April 27, 2009

“Threshold sample enrichment approach with heterogeneous populations in a clinical trial for preeclampsia”. University of Pennsylvania Conference on Statistical Issues in Clinical Trials: From Bench to Bedside to Community, Philadelphia, PA, April 29, 2009

“An efficient rank-based test for comparison of multidimensional outcomes”. International Chinese Statistical Association Applied Statistics Symposium, San Francisco, CA, June 2009

“A threshold sample-enrichment approach in a clinical trial with heterogeneous subpopulations”. International Biometric Society (ENAR) Spring Meeting, New Orleans, LA, March, 2010

“A rank-based test for comparison of multidimensional outcomes”. Department of Biostatistics and Bioinformatics, Duke University. April 2010

“A min-max combination of biomarkers to improve diagnostic accuracy”. First Joint Biostatistics symposium, Beijing, China, July 2010

“Optimality of group testing in the presence of misclassification”. International Workshop on the Frontier of Statistics, Beijing, China, July 2010

“Using group testing to evaluate gene-environment interaction”. International Chinese Statistical Association Applied Statistics Symposium, New York City, NY, June 2011

“Optimality of group testing in the presence of misclassification”. Department of Statistics, Pennsylvania State University, September 2011

“A nonparametric procedure to compare clustered multiple endpoints”. Department of Mathematics and Statistics, University of Maryland at Baltimore County, Baltimore, MD, October 2011

“Combining biomarkers to improve diagnostic accuracy”. International Biometric Society (ENAR) Spring Meeting, Washington, DC, April 2012

“Adjusting for misclassification in stratified biomarker clinical trials”. Department of Biostatistics and Bioinformatics, Duke University, May 2012

“Optimality of group testing in the presence of misclassification”. International Chinese Statistical Association Applied Statistics Symposium, Boston, MA, June 2012

“From diagnostic biomarkers to innovative clinical trials-A statistician’s perspective”. Division of Biostatistics, UMD Marlene and Stewart Greenebaum Cancer Center, April 2013

“Some statistical challenges in the design and analysis of gestational diabetes studies”. Joint Statistical Meetings, Montreal, Canada, August 2013

“A nonparametric procedure to compare clustered multiple endpoints”. Department of Biostatistics-SLAM Working Group, Johns Hopkins University, September 2013

“Group testing in the presence of misclassification”. Department of Mathematical Sciences, New Jersey Institute of Technology, November 2015

“On design and analysis of a stratified biomarker time-to-event clinical trial in the presence of measurement Error”. International Chinese Statistical Association Applied Statistics Symposium, Fort Collins, CO, June 2015

Contributed Presentations

“Uniformly minimum variance unbiased estimation of the drift of Brownian motion with parallel or triangular stopping boundaries.” International Chinese Statistical Association Applied Statistics Symposium, Baltimore, MD, June 1996

“Uniformly minimum variance unbiased estimation of the drift of Brownian motion with parallel or triangular stopping boundaries.” Joint Statistical Meetings, Chicago, IL, August 1996

“Unbiased estimation following sequential tests”. International Biometric Society (ENAR) Spring Meeting, Memphis, TN, March 1997

“Two simple estimates following a sequential test”. International Biometric Society (ENAR) Spring Meeting, Pittsburgh, PA, March 1998

“Sequential tests and estimates after overrunning”. Joint Statistical Meetings, Baltimore, MD, August 1999

“Analysis of secondary endpoints following sequential clinical trials”. International Biometric Society (ENAR) Spring Meeting, Atlanta, GA, March 1999

“Analysis of secondary endpoints following sequential clinical trials”. International Chinese Statistical Association Applied Statistics Symposium, Washington, DC, June 1999

“Sample size and power determination for clustered repeated measurements”. International Biometric Society (ENAR) Spring Meeting, Chicago, IL, March 2000

“Visualization of gene microarray data using block principal component analysis”. International Biometric Society (ENAR) Spring Meeting, Charlotte, NC, March 2001

“Visualization of gene microarray data using block principal component analysis”. National Cancer Institute SPORE Microarray Workshop on Informatics, San Francisco, CA, June 2001

“Nonparametric inference on the partial area under receiver operating characteristic curves”. Mid- Atlantic Probability and Statistics Day, George Washington University, Washington, DC, November 2002

“Conditional receiver operating characteristic curves for evaluation of diagnostic accuracy in matched case-control studies”. The 2nd International Biometric Society Conference of the Eastern Mediterranean Region (EMR), Antalya, Turkey, January 2003

“Design and analysis of comparative diagnostic accuracy studies with multiple correlated test results”. International Biometric Society (ENAR) Spring Meeting, Tampa, FL, March 2003

“Conditional receiver operating characteristic curves for evaluation of diagnostic accuracy with clustered data”. Joint Statistical Meetings, San Francisco, CA, August 2003

“Unbiased estimation following a group sequential test for distributions in the exponential family”. Joint Statistical Meetings, Toronto, Canada, August 2004

“Estimating rates in a multistage phase II trial” (poster presentation). National Institutes of Health Research Festival, September 2004

“Supplementary analysis of probabilities at the termination of a group sequential phase II trial”. International Biometric Society (ENAR) Spring Meeting, Austin, TX, March 2005

“Multistage evaluation of measurement error in a reliability study” (poster presentation). National Institutes of Health Research Festival, October 2005

“Multistage evaluation of measurement error in a reliability study”. International Conference on Design and Experiments, Tianjin, China, July 2006

“Nonparametric procedures for comparing correlated multiple endpoints with applications to oxidative stress biomarkers”. International Biometric Society (ENAR) Spring Meeting, San Antonio, TX, March 2009

“Two-stage procedures for selecting the best diagnostic biomarkers” (Topic Contributed). Joint Statistical Meetings, Washington, DC, August 2009

“A Nonparametric Procedure to Compare Clustered Multiple Endpoints”. 7th International Conference on Multiple Comparison Procedures (MCP), Washington, DC, August 2011

“Adjusting for misclassification in stratified biomarker clinical trials”. (Topic-Contributed) Joint Statistical Meeting, San Diego, CA, August 2012

“Nonparametric Comparison of Longitudinal Profiles of Healthy Eating Index Scores”. ) Joint Statistical Meeting, Seattle, WA, August 2015

Past Collaborative Research Prior to NIH

University of Rochester Medical Center (September 1993-July 1997)

Research Associate (June 1997-July 1998) and Consultant (August 1998-June 2000) on “Secondary inference in cardiovascular clinical trials” (NIH/R01 HL58751), NHLBI (July 1, 1997 to June 30, 2000). Principal Investigator: W. Jack Hall, Department of Biostatistics

St. Jude Children's Research Hospital (August 1997-March 1999)

Co-Investigator on “Nutrient intakes of hospitalized pediatric patients on oncology services: A comparison of patients dinning with caregivers versus patients dinning independently”. Principal Investigator: Ruth Williams, Department of Clinical Nutrition

Co-Investigator on “Nutritional, clinical and biological effects of glutamine supplementation in children with sickle cell disease”. Principal Investigator: Ruth Williams, Department of Clinical Nutrition

Georgetown University Lombardi Cancer Center (March 1999-Februray 2002)

Biostatistics Core Grant (30%) on “Cancer center support grant” (NIH/5P30 CA51008, $1,653,617), NCI (May 1, 1997-April 30, 2002). Principal Investigator: Marc Lippman

Co-Investigator (5%) on “Breast cancer center grant” (CC950002, $1,200,038), DOD (July 1, 1996-June 30, 2000). Principal Investigator: Marc Lippman

Co-Investigator (5%) on “PKC modulation in patients with advanced cancer” (NIH/R01 CA71856, $123,000), NCI (July 1, 1996-June 30, 2000). Principal Investigator: John Marshall

Co-Investigator (5%) on “Health promotion for women at risk for breast cancer” (NIH/R01 CA74869, $74,307), NCI (August 1, 1998-May 5, 2003). Principal Investigator: Janet Audrain

Co-Investigator (5% in years 1-2 and 10% in years 3-5) on “Transdisciplinary Tobacco Use Research Center (TTURC)” (NIH/1p50 CA84718-01, $2,207,020), NCI (September 30, 1999- September 29, 2004). Principal Investigator: Caryn Lerman

Co-Investigator (5%) on “Genetic counseling for breast cancer susceptibility in African American women”, DOD (July 2000-June 2005). Principal Investigator: Chanita Hughes

Co-Investigator (5%) on “Anticancer therapeutic potential of VEGI, an antiangiogenic cytokine”, DOD (March 2001-February 2004). Principal Investigator: Luyuan Li

Co-Investigator (5%) on “Polymorphic polyglutamine of A1B1 and its relationship to breast cancer”, DOD (March 2001-February 2004). Principal Investigator: Lee-Jun Wong

Co-Investigator (5%) on “Mitochondrial DNA mutations in breast cancer”, DOD (March 2001- February 2004). Principal Investigator: Lee-Jun Wong

Co-investigator (20% in year three) on “Mutagen sensitivity, apoptosis, and polymorphism in DNA repair as measures of prostate cancer risk”, DOD (November 2001-October 2004). Principal Investigator: Radoslav Goldman

Major Collaborative Studies at NICHD

Family Management of Diabetes Multisite Main Trial (FMOD), PI: Tonja Nansel, HBB

Cultivating Healthy Environments in Families with Type 1 Diabetes (CHEF), PI: Tonja Nansel, HBB

Trinity Students Study (TSS), PI: Jim Mills, EB Genetic Factors in Birth Defects, PI: Jim Mills, EB

Diabetes & Women's Health: A Study of Long-Term Health Implications of Glucose Intolerance in Pregnancy (DWH), PI: Cuilin Zhang, EB

Transgenerational Study of GDM and Obesity, PI: Cuilin Zhang, EB. Pregnancy Eating Attributes Study (PEAS), PI: Tonja Nansel, HBB

2-hydroxypropyl-β-cyclodextrin in Patients with Niemann-Pick Disease Type C1, PI: Forbes Porter, DIR

Peer-Reviewed Research Articles

  1. Liu A. On the best estimation of variance in linear models. Mathematical Statistics and Applied Probability 1988; 3: 232-236.
  2. Wang S, Liu A. Relative efficiency of two-stage estimators. Acta Mathematica Sinica 1989; 32: 42-54.
  3. Liu A, Wang S. A new relative efficiency of least squares estimates in linear models. Chinese Journal of Applied Probability and Statistics 1989; 5: 97-104.
  4. Liu A, Wang, S. Biased estimators for the parameters of a class of related regression system. Chinese Journal of Applied Probability and Statistics 1991; 7: 266-274.
  5. Liu A. An improvement of principal components estimator for seemingly unrelated regression equations. Mathematical Statistics and Applied Probability 1993; 8: 70-75.
  6. Liu A. An efficient estimation of seemingly unrelated multivariate regression models with application to growth curves analysis. Statistica Sinica 1993; 3: 421-434.
  7. Liu A. Selection of covariates and estimation of parameters in growth curve models. Acta Mathematica Sinica 1994; 37: 362-372.
  8. Liu A. Estimation of the parameters in two linear models with only some of the parameter vectors identical. Statistics and Probability Letters 1996; 29: 369-375.
  9. Liu A. On the maximum likelihood estimate for the drift of Brownian motion following a symmetric sequential probability ratio test. Communications in Statistics---Theory and Methods 1997; 26: 977-989.
  10. Liu A. Detecting influential covariates in a growth curve model. Computational Statistics and Data Analysis 1998; 28: 105-113.
  11. Liu A, Hall WJ. Minimum variance unbiased estimation of the drift of Brownian motion with linear stopping boundaries. Sequential Analysis 1998; 17: 91-107.
  12. Liu A, Hall WJ. Unbiased estimation following a group sequential test. Biometrika 1999; 86: 71-78.
  13. Gajjar A, Fouladi M, Walter A, Thompson S, Reardon D, Merchant T, Jenkins J, Liu A, Boyett J, Kun L, Heideman R. Comparison of lumbar and shunt cerebrospinal fluid specimens for cytologic detection of leptomeningeal disease in pediatric patients with brain tumors. Journal of Clinical Oncology 1999; 17: 1825-1828.
  14. Fouladi M, Gajjar A, Boyett J, Walter W, Thompson S, Merchant T, Jenkins J, Langston J, Liu A, Kun L, Heideman R. Comparison of CSF cytology and spinal magnetic resonance imaging in the detection of leptomeningeal disease in pediatric medullblastoma or primitive neuroectodermal tumor. Journal of Clinical Oncology 1999; 17: 3234-3237.
  15. Liu A, Boyett J, Xiong XP. Sample size calculation for planning group sequential longitudinal trials. Statistics in Medicine 2000; 19: 205-220.
  16. Liu A, Tan M, Boyett J, Xiong XP. Testing secondary hypotheses following sequential clinical trials. Biometrics 2000; 56: 640-644.
  17. Liu A. Maximum likelihood estimate following sequential probability ratio tests. Sequential Analysis 2000; 19: 63-75.
  18. Smith K, Hale GM, Williams R, Ludwig M, Thompson A, Bowman L, Shochat S, Liu A, Barkley C. Comparison of two different low profile gastrostomy enteral feeding devices in pediatric oncology patients. Nutrition and Clinical Practice 2000; 15: 189-192.
  19. Hayes AJ, Huang W, Yu J, Maisonpierre PC, Liu A, Kern FG, Lippman ME, McLeskey SW, Li L. Expression and function of angiopoietin-1 breast cancer. British Journal of Cancer 2000; 83: 1154-1160.
  20. Pedrosa F, Bonilla M, Liu A, Smith K, Davis D, Ribeiro RC, Wilimas JA.. Effect of malnutrition at the time of diagnosis on the survival of children treated for cancer in El Salvador and northern Brazil. Journal of Pediatric Hematology/Oncology 2000; 22: 502-505.
  21. Liu A, Hall WJ. Unbiased estimation of secondary parameters following a sequential test. Biometrika2000; 88: 895-900.
  22. Liu A, Shih WJ, Gehan E. Sample size and power determination for clustered repeated measurements. Statistics in Medicine 2002; 21: 1787-1801.
  23. Liu A. Efficient estimation of two seemingly unrelated regression equations. Journal of Multivariate Analysis 2002; 82: 445-456.
  24. Liu A, Zhang Y, Gehan E, Clarke R. Block principal component analysis with application to gene microarray data classification. Statistics in Medicine 2002; 21: 3465-3474.
  25. Hall WJ, Liu A. Sequential tests and estimates after overrunning based on maximum- likelihood ordering. Biometrika 2002; 89: 699-70.
  26. Poola I, Abraham J, Liu A. Estrogen receptor beta splice variant mRNAs are differentially altered during breast carcinogenesis. Journal of Steroid Biochemistry and Molecular Biology 2002; 82: 169-179.
  27. Lerman C, Roth D, Kaufmann V, Audrain J, Hawk L, Liu A, Niaura R, Epstein L. Mediating mechanisms for the impact of bupropion in smoking cessation treatment. Drug and Alcohol Dependence 2002; 67: 219-223.
  28. Gu Z, Lee RY, Skaar TC, Bouker KB, Welch JN, Lu J, Liu A, Zhu Y, Davis N, Leonessa F, Brunner N, Wang Y, Clarke R. Association of interferon regulatory Factor-1, Nucleophosmin, nuclear Factor-kB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780). Cancer Research 2002; 62: 3428-3437.
  29. Ellis M, Davis N, Coop A, Liu M, Schumaker L, Lee RY, Srikanchana R, Russell CG, Singh B, Miller WR, Stearns V, Pennanen M, Tsangaris T, Gallagher A, Liu A, Zwart A, Hayes DF, Lippman ME, Wang Y, Clarke R. Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses. Clinical Cancer Research 20002; 8: 1155-1166.
  30. Wong LJ, Wong IH, Liu A. Intergenerational transmission of pathogenic heteroplasmic mitochondrial DNA. Genetics in Medicine 2002; 4: 78-83.
  31. Liu A. A simple low-bias estimate following a sequential test with linear boundaries. In: Crossing Boundaries: Statistical Essays in Honor of Jack Hall, IMS Monograph Series, Kolassa J and Oakes D, Editors, 2003; p 47-58.
  32. Mazumdar M, Liu A. Group sequential design for comparative diagnostic accuracy studies. Statistics in Medicine 2003; 22: 727-739.
  33. Liu A, Schisterman EF. Comparison of diagnostic accuracy of biomarkers with pooled assessments. Biometrical Journal 2003; 45: 631-644.
  34. Liu A, Troendle JF, Yu KF, Yuan V. Conditional maximum likelihood estimation following a group sequential test. Biometrical Journal 2004; 46: 760-768.
  35. Liu A, Schisterman EF, Teoh E. Sample size and power calculation in comparing diagnostic accuracy of biomarkers with pooled assessments. Journal of Applied Statistics 2004; 31: 49-59.
  36. Blancato J, Singh B, Liu A, Liao DJ, Dickson RB. Correlation of amplification and over- expression of the c-myc oncogene in high-grade breast cancer: FISH, in situ hybridisation, and immunohistochemical analyses. British Journal of Cancer 2004; 90:1612-1619.
  37. Dimitrakakis C, Jones RA, Liu A, Bondy CA. Breast cancer incidence in menopausal women using testosterone in addition to usual hormone therapy. Menopause 2004; 11:531-535.
  38. Liu A, Schisterman EF, Zhu Y. On linear combinations of biomarkers to improve diagnostic accuracy. Statistics in Medicine 2005; 24: 37-47.
  39. Liu A, Wu CQ, Yu KF, Gehan E. Supplementary analysis of probabilities at the termination of a group sequential phase II trial. Statistics in Medicine 2005; 24: 1009-1027
  40. Troendle, JF, Liu A, Wu CQ, Yu KF. Sequential testing for efficiency in clinical trials with non-transient effects. Statistics in Medicine 2005; 24: 3239-3250.
  41. Liu A, Schisterman EF, Mazumdar M, Hu J. Power and sample size calculation of comparative diagnostic accuracy studies with multiple correlated test results. Biometrical Journal 2005; 47: 140-150.
  42. Liu A, Schisterman EF, Wu CQ. Nonparametric estimation and hypothesis testing on the partial area under receiver operating characteristic curves. Communications in Statistics---Theory and Methods 2005; 34: 2077-2088.
  43. Guo H, Liu A. A simple and efficient bias-reduced estimator of response probability following a group sequential phase II trial. Journal of Biopharmaceutical Statistics 2005; 15: 773–781.
  44. Schisterman EF, Perkins N, Liu A, Bondell H. Optimal cut-point and its corresponding Youden index to discriminate individuals using pooled blood samples. Epidemiology 2005; 16: 73-81.
  45. Wu CQ, Liu A, Yu KF. Estimation of secondary parameters after a multivariate group sequential test. In Contemporary Multivariate Analysis and Experimental Designs-In Celebration of Professor Kai-Tai Fang's 65th Birthday, 2005; pp. 337-350. Fan J, Li G, Editors. The World Scientific Publisher.
  46. Poola I, Fuqua SAW, DeWitty RL, Abraham J, Marshallack JJ, Liu A. ERα- negative breast cancer tissues express significant level of ERβ1 and ERβ5: potential molecular targets(s) for chemo-prevention. Clinical Cancer Research 2005; 1, 7579-7585.
  47. Zhu Y, Singh B, Hewitt S, Liu A, Gomez B, Wang A, Clarker R. Expression patterns among interferon regulatory factor-1, human X-box binding protein-1, nuclear factor kappa B, nucleophosmin, estrogen receptor-alpha and progesterone receptor proteins in breast cancer tissue microarrays. International Journal of Oncology 2006; 28: 67-76.
  48. Liu A, Hall WJ, Yu KF, Wu CQ. Estimation following a group sequential test for distributions in the one-parameter exponential family. Statistica Sinica 2006; 16: 165-181.
  49. Liu A, Schisterman EF, Wu CQ. Multistage evaluation of measurement error in a reliability study. Biometrics2006; 62:1190–1196.
  50. Schisterman EF, Vexler A, Whitcomb BW, Liu A. The limitations due to exposure detection limits for regression models. American Journal of Epidemiology 2006; 163: 374-383.
  51. Vexler A, Liu A, Schisterman EF, Wu CQ. Note on distribution-free estimation of maximum linear separation of two multivariate distributions. Journal of Nonparametric Statistics 2006; 18: 145-158.
  52. Mumford SL, Schisterman EF, Vexler A, Liu A. Pooling biospecimens and limits of detection: Effects on ROC curve analysis. Biostatistics2006; 7: 585-598.
  53. Vexler A, Liu A, Schisterman EF. Efficient design and analysis of biospecimens with measurements subject to detection limit. Biometrical Journal 2006; 7: 780-791.
  54. Liu A, Wu CQ, Yu KF, Yuan, V. Estimation following a multivariate group sequential test. Journal of Multivariate Analysis 2007; 98: 505-516.
  55. Wu CQ, Liu A. An adaptive approach for bivariate phase II clinical trial designs. Contemporary Clinical Trials 2007; 28: 482-486.
  56. Ferrari RM, Cooney MA, Vexler A, Liu A, Buck Louis GM. Time-to-pregnancy multiple births. Human Reproduction 2007; 22: 407-413.
  57. Bondell HD, Liu A, Schisterman EF. Statistical inference based on pooled data: A moment- based estimating equation approach. Journal of Applied Statistics 2007; 34: 129-140.
  58. Bai RK, Leal SM, Covarrubias D, Liu A, Wong LJ. Mitochondrial genetic background modifies breast cancer risk. Cancer Research 2007; 67: 4687-4694.
  59. Liu A, Wu CQ, Yu KF. Incorporating overrunning data into the analysis of both primary and secondary endpoints in a sequential trial. In Random Walk, Sequential Analysis and Related Topics- A Festschrift in Honor of Yuan-Shih Chow. Ying ZL, Zhang CH Editors. The World Scientific Publisher: New Jersey, 2007; pp. 56-68.
  60. Bloom MS, Buck Louis GM, Schisterman EF, Liu A, Kostyniak PK. Maternal serum polychlorinated biphenyl concentrations across critical windows of human development. Environmental Health Perspectives 2007; 115: 1320-1324.
  61. Shu Y, Liu A, Li ZH. Sequential evaluation of a medical diagnostic test with binary outcomes. Statistics in Medicine 2007; 26: 4416-4427.
  62. Vexler A, Schisterman EF, Liu A. Estimation of ROC based on stably distributed biomarkers subject to measurement error and pooling mixtures. Statistics in Medicine 2008; 27:280–296.
  63. Wu CQ, Liu A, Yu KF. An adaptive approach to designing comparative diagnostic accuracy studies. Journal of Biopharmaceutical Statistics 2008; 18: 116-125.
  64. Browne RW, Bloom MS, Schisterman EF, Hovey K, Trevisan M, Wu CQ, Liu A, Wactawski- Wende J. Analytical and biological variation of biomarkers of oxidative stress during the menstrual cycle. Biomarkers 2008; 13:160-183.
  65. Liu A, Wu CQ, Yu KF. Point and interval estimation of primary and secondary parameters in a two-stage adaptive clinical trial. Journal of Biopharmaceutical Statistics 2008; 18:211-226.
  66. Liu A, Wu CQ, Schisterman EF. Nonparametric sequential evaluation of diagnostic biomarkers. Statistics in Medicine 2008; 27:1667-1678.
  67. Liu A, Wu CQ, Yu KF. Two-stage procedures for selecting the best diagnostic biomarkers. Philosophical Transaction of the Royal Society A 2008; 366: 2293-2299.
  68. Shu Y, Liu A, Li ZH. Point and interval estimates of accuracies of a binary medical diagnostic test in group sequential designs. Philosophical Transaction of the Royal Society A 2008; 366:2335- 2345.
  69. Vexler A, Liu A, Eliseeva E, Schisterman EF. Maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection. Biometrics 2008; 64: 895-903.
  70. Zhang J, Masciocchi M, Lewis D, Sun W, Liu A, Wang Y. Placental anti-oxidant gene polymorphisms, enzyme activity, and oxidative stress in preeclampsia. Placenta 2008; 29: 439-443.
  71. Poola I, Abraham J, Liu A, Marshalleck J, DeWitty R. The cell surface estrogen receptor, G protein-coupled receptor 30 (GPR30), is markedly down-regulated During Breast Tumorigenesis. Breast Cancer: Basic and Clinical Research 2008; 1: 65-78.
  72. Wactawski-Wende J, Schisterman EF, Hovey KM, Howards P, Browne RW, Hediger M, Liu A, Trevisan M ; BioCycle Stusy Group. BioCycle Study: Design of the longitudinal study of the oxidative stress and hormone variation during the menstrual cycle. Paediatric and Perinatal Epidemiology 2009; 23: 171-184.
  73. Wu MX, Yu KF, Liu A. Exact inference on contrasts in means of intraclass correlation models with missing responses. Journal of Multivariate Analysis 2009; 100: 301-308.
  74. Li, QZ, Liu A, Yu K, Yu, KF. A weighted rank-sum procedure for comparing samples with multiple endpoints. Statistics and Its Interface 2009; 2: 197-201.
  75. Wu MX, Yu KF, Liu A. Estimation of variance components in the mixed-effects models: A comparison between analysis of variance and spectral decomposition. Journal of Statistical Planning and Inference 2009; 139: 3962-3973.
  76. Yang S, Liu A, Weidenhammer A, Cooksey RC, McClain D, Kim MK, Aguilera G, Abel ED, Chung JH. (2009). The role of mPer2clock gene in glucocorticoid and feeding rhythms. Endocrinology 2009; 150: 2153-2160.
  77. Vexler A, Wu CQ, Liu A, Whitcomb BW, Schisterman EF. An extension of a change point problem. Statistics 2009; 3: 213-225.
  78. Tang L, Liu A. Sample size recalculation in sequential diagnostic trials. Biostatistics 2010; 11: 151-163.
  79. Li QZ, Zheng G, Liu A, Xiong SF, Li ZH, Yu K. The limiting bound of Efron's W-formula for hypothesis testing when a nuisance parameter is present only under the alternative. Journal of Statistical Planning and Inference 2010; 140: 1610–1617.
  80. Liu A, Li QZ, Liu CL, Yu K, Yu KF. A Rank-Based test for comparison of multidimensional outcomes. Journal of the American Statistical Association 2010; 105: 578-587.
  81. Whitcomb BW, Bodach SD, Mumford SL, Perkins NJ, Trevisan M, Wactawski-Wende J, Liu A, Schisterman EF. Ovarian function and cigarette smoking. Paediatric and Perinatal Epidemiology 2010; 25: 433-440.
  82. Vexler A, Liu A, Schisterman EF. Nonparametric deconvolution of density estimation based on observed sums. Journal of Nonparametric Statistics 2010; 22: 23-29.
  83. Liu A, Liu CL, Li, QZ, Yu KF, Yuan V. A threshold sample-enrichment approach in a clinical trial with heterogeneous populations. Clinical Trials 2010; 7:537-545.
  84. Li QZ, Zheng G, Liu A, Li ZH, Yu K. Approximating probabilities of correlated events with applications to multiple testing. Science in China A 2010; 53:2937-2948.
  85. Liu CL, Liu A, Halabi S. Min-max combination of biomarkers to improve diagnostic accuracy. Statistics in Medicine 2011; 30: 2005–2014.
  86. Pan D, Li, QZ, Jiang N, Liu A, Yu K. Robust joint analysis allowing for model uncertainty in two-stage genetic association studies. BMC Bioinformatics 2011; 12(1):9.
  87. Yan LK, Liu A, Li ZH, Zheng G. Optimal two-stage sequential design for case-control genetic association studies. Statistics and Its Interface 2011; 4:431–441.
  88. Liu A, Liu CL, Zhang Z, Albert PF. Optimality of group testing in the presence of misclassification. Biometrika2012; 99:245–251. [DOI: 10.1093/biomet/asr064 ; PMID: 23049137; PMCID: PMC3412609]
  89. Mills JL, Carter TC, Kay DM, Browne ML, Brody LC, Liu A, Romitti PA, Caggana M, Druschel CM. Folate and vitamin B12 related genes and risk for omphalocele. Human Genetics 2012; 131:739–746. [DOI: 10.1007/s00439-011-1117-3; PMID: 22116453; PMCID: PMC3374579]
  90. Nansel TR, Iannotti RJ, Liu A. Clinic-integrated behavioral intervention for families of youth with type 1 diabetes: A Randomized Clinical Trial. Pediatrics 2012; 129:866-873. [DOI: 10.1542/peds.2011-2858; PMID: 22392172; PMCID: PMC3313642]
  91. Wu MX, Yu KF, Liu A, Ma TF. Simultaneous optimal estimation in linear mixed effects models. Metrika2012; 75:471–489. [DOI: 10.1007/s00184-010-0337-1]
  92. Browne ML, Caner TC, Kay DM, Kuehn D, Brody LC, Romitti PA, Liu A, Caggana M, Druschel CM, Mills JM. Evaluation of genes involved in limb development, angiogenesis, and coagulation as risk factors for congenital limb deficiencies. American Journal of Medical Genetics A: 2012; 2643-2472. [DOI: 10.1002/ajmg.a.35565; PMID: 22965740; PMCID: PMC3448837]
  93. Fan R, Zhang Y, Albert PS, Liu A, Wang Y, Xiong M. Longitudinal association analysis of quantitative traits. Genetic Epidemiology 2012; 36:856–869. [DOI: 10.1002/gepi.21673; PMID: 22965819; PMCID: PMC4444073]
  94. Zhang Z, Liu A, Lyles RH, Mukherjee B. Logistic regression analysis of biomarker data subject to pooling and dichotomization. Statistics in Medicine 2012; 31:2473-2484. [DOI: 10.1002/sim.4367; PMID: 21953741]
  95. Song Y, Yeung E, Liu A, VanderWeele TJ, Chen L, Lu C, Liu C, Schisterman EF, Ning Yi, Zhang C. Pancreatic beta-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses. Human Molecular Genetics 2012; 21(22):5010-5018. [DOI: 10.1093/hmg/dds339; PMID: 22936689; PMCID: PMC3607483]
  96. Carter TC, Kay DM Brownw ML, Liu A, Romitti PA, Kuehn D, Conley MR, Caggana M, Druschel CM, Brody LC, Mills JL. Hirschsprung's disease and variants in genes that regulate enteric neural crest cell proliferation, migration, and differentiation. Journal of Human Genetics 2012; 57:485-493. [DOI: 10.1038/jhg.2012.54; PMID: 22648184; PMCID: PMC3503526]
  97. Tang LL, Liu A, Schisterman EF, Zhou XH, Liu CC. Homogeneity tests of clustered diagnostic markers with applications to the BioCycle Study. Statistics in Medicine 2012; 31:3638-3648. [DOI: 10.1002/sim.5391; PMID: 22733707; PMCID: PMC4084872]
  98. Carter TC, Kay DM, Browne ML, Liu A, Romitti PA, Kuehn D, Conley MR, Caggana M, Druschel CM, Brody LC, Mills JL. Anorectal atresia and variants at predicted regulatory sites in candidate genes. Annals of Human Genetics 2013; 77:31-46. [DOI: 10.1111/j.1469- 1809.2012.00734.x; PMID: 23127126]
  99. Tang LL, Kang L, Liu C, Schisterman EF, Liu A. An additive selection of markers to improve diagnostic accuracy based on a discriminatory measure. Academic Radiology 2013; 20:854–862. [DOI: 10.1016/j.acra.2013.02.009; PMID: 23611438; PMCID: PMC4172320]
  100. Fan R, Lee A, Lu Z, Liu A, Troendle JF, Mills JL. Association analysis of complex disease using triads, parent-child dyads and singleton monads. BMC Genetics 2013; 14:78. [DOI: 10.1186/1471-2156-14-78; PMID: 24007308; PMCID: PMC3844511]
  101. Tang L, Liu A, Chen Z, Schisterman EF, Zhang B, Miao Z. Nonparametric ROC summary statistics for clustered diagnostic marker data. Statistics in Medicine 2013; 32: 2209-2220. [DOI: 10.1002/sim.5654; PMID: 23055248; PMCID: PMC3578098]
  102. Jin M, Liu A, Chen Z, Li ZH. Sequential testing of measurement errors in inter-rater reliability studies. Statistica Sinica 2013; 23:1743-1759. [DOI: http://www3.stat.sinica.edu.tw/statistica/J23N4/J23N415/J23N415.html External Web Site Policy PMID: 25525316; PMCID: PMC4267541]
  103. Sarkar C, Chandra G, Peng S, Zhang Z, Liu A, and Mukherjee AB. Neuroprotection and lifespan extension in Ppt1(-/-) mice by NtBuHA: therapeutic implications for INCL. Nature Neuroscience 2013; 16:1608-1617. [DOI: 10.1038/nn.3526; PMID: 24056696; PMCID: PMC3812271]
  104. Liu C, Liu A, Zhang B, Zhang Z. Improved confidence intervals of a small probability from pooled testing with misclassification. Frontiers in Public Health 2013; 1-39. [DOI: 10.3389/fpubh.2013.00039; PMID: 24350208; PMCID: PMC3859966]
  105. Kang L, Liu A, Tian L. Linear combination methods to improve diagnostic/prognostic accuracy on future observations. Statistical Methods in Medical Research 2013. [PMID: 23592714; PMCID: PMC4180010]
  106. Li ZB, Liu A, Li ZH, LI QZ. Rank-based tests for comparison of multiple endpoints among several populations. Statistics and Its Interface 2014; 7: 9-18. [DOI: http://dx.doi.org/10.4310/SII.2014.v7.n1.a2 External Web Site Policy]
  107. Li QZ, Xiong WJ, Chen J, Zheng G, Li ZH, Mills JM, Liu A. A robust test for quantitative trait in genetic association studies. Statistics and Its Interface 2014; 7:61-68. [DOI: http://dx.doi.org/10.4310/SII.2014.v7.n1.a7 External Web Site Policy]
  108. Albert PS, Liu A, Nansel T. Efficient logistic regression designs under an imperfect population identifier. Biometrics 2014; 70:175-184. [DOI: 10.1111/biom.12106; PMID: 24261471; PMCID: PMC3954435]
  109. Nansel TR, Lipsky LM, Liu A, Laffel L, Mehta S. Contextual factors are associated with diet quality in youth with type 1 diabetes. Journal of the Academy of Nutrition and Dietetics 2014; 114:1223-1229. [DOI: 10.1016/j.jand.2014.01.012; PMID: 24651028; PMCID: PMC4111984]
  110. Liu C, Liu A, Hu J, Yuan V, Halabi S. Adjusting for misclassification in stratified biomarker clinical trials. Statistics in Medicine 2014; 33:3100-3113. [DOI: 10.1002/sim.6164; PMID: 24733510; PMCID: PMC4107031]
  111. Mills JL, Fan R, Brody LC, Liu A, Ueland PM, Wang Y, Kirke PN, Shane B, Anne Molloy AM. Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects. The American Journal of Clinical Nutrition 2014; 100:1069-1074. [DOI: 10.3945/ajcn.113.079319; PMID: 25240073; PMCID: PMC4163794]
  112. Chen L, Yuan A, Liu A, Chen G. Longitudinal data analysis using Bayesian-frequentist hybrid random effects model. Journal of Applied Statistics 2014; 41:2001-2010. [DOI:10.1080/02664763.2014.898137; PMID: 25143663; PMCID: PMC4133133]
  113. Levin SW, Baker EH, Zein WM, Zhongjian Zhang Z, Quezado ZMH, Miao N, Gropman A, KJ, Bianconi S, Chandra G, Khan OI, Caruso RC, Liu A, Mukherjee AB. Oral cysteamine bitartrate and N-acetylcysteine for patients with infantile neuronal ceroid lipofuscinosis: a pilot study. Lancet Neurology 2014; 13:777-787. [DOI: 10.1001/archneurol.2009.263; PMID: 24997880; PMCID: PMC4139936]
  114. Bao W, Tobias DK, Bowers K, Chavarro J, Vaag A, Grunnet LG, Strøm M, Mills J, Liu A, Kiely M, Zhang C. Physical activity and sedentary behaviors associated with risk of progression from gestational diabetes mellitus to type 2 diabetes mellitus: a prospective cohort study. JAMA Internal Medicine 2014; 174:1047-1055. [DOI: 10.1001/jamainternmed.2014.1795; PMID: 24841449; PMCID: PMC4209161]
  115. Zhang Z, Nie L, Soon G, Liu A. The use of covariates and random effects in evaluating predictive biomarkers under a potential outcome framework. Annual of Applied Statistics 2014; 8:2336–2355. [DOI: 10.1214/14-AOAS773; PMID: 26779295]
  116. Zhang CL, Hu FB, Olsen SF, Vaag A, Gore-Langton R, Cbavarro JE, Bao W, Yeung E, Bowers K, Grunnet LG, Sherman S, Kiely M, Strom M, Hansen S, Liu A, Mills J, Fan R, on behalf of the DWH study team. Rationale, design, and method of the Diabetes & Women's Health study--a study of long-term health implications of glucose intolerance in pregnancy and their determinants. Acta Obstetricia et Gynecologica Scandinavica 2014; 93:1123-1130. [DOI: 10.1111/aogs.12425; PMID: 24828694; PMCID: PMC4205761]
  117. Yeung EH, Liu A, James Mills J, Zhang C, Männistö T, Lu Z, Tsai MY, Pauline Mendola P. Increased levels of copeptin before clinical diagnosis of preeclampsia. Hypertension 2014; 64:1362-1367. [DOI: 10.1161/HYPERTENSIONAHA.114.03762; PMID: 25225209]
  118. Zhang Z, Liu C, Kim S, Liu A. Prevalence estimation subject to misclassification: the misspecification bias and some remedies. Statistics in Medicine 2014; 33:4482-4500. [DOI: 10.1002/sim.6268; PMID: 25043925; PMCID: PMC4184986]
  119. Wang Y, Liu A, Mills JL, Boehnke M, Wilson AF, Bailey-Wilson JE, Xiong M, Wu CO, Fan R. Pleiotropy analysis of quantitative traits at gene level by multivariate functional linear models. Genetic Epidemiology 2015; 39:259-275. [DOI: 10.1002/gepi.21895; PMID: 25809955; PMCID: PMC4443751]
  120. Nansel TR, Laffel LMB, Haynie DL, Mehta SN, Lipsky LM, Volkening LK, Butler DA, Higgins LA, Liu A. Improving dietary quality in youth with type 1 diabetes: randomized clinical trial of a family-based behavioral intervention. International Journal of Behavioral Nutrition and Physical Activity 2015; 12(1):58. [DOI: 10.1186/s12966-015-0214-4; PMID: 25952160; PMCID: PMC4436744]
  121. Nansel TR, Thomas DM, Liu A. Efficacy of a behavioral intervention across income in pediatric type 1 diabetes. American Journal of Preventive Medicine 2015; 49: 930-934. [DOI: 10.1016/j.amepre.2015.05.006; PMID: 26231856]
  122. Rigler SL, Kay DM, Sicko RJ, Fan R, Liu A, Caggana M, Browne ML, Druschel CM, Romitti PA, Brody LC, Mills JL. Novel copy number variants in a population-based investigation of classic heterotaxy. Genetics in Medicine 2015; 17: 348-357. [DOI: 10.1038/gim.2014.112; PMID: 25232849]
  123. Boghossian NS, Sicko RJ, Kay DM, Rigler SL, Caggana M, Tsai M, Yeung EH, Pankratz N, Cole BR, Druschel CM, Romitti PA, Browne ML, Fan RZ, Liu A, Brody LC, Mills JM. Rare copy number variants implicated in posterior urethral valves. American Journal of Medical Genetics 2015; 170: 622-633. [DOI: 10.1002/ajmg.a.37493; PMID: 26663319]
  124. Zhu Y, Olsen SF, Mendola P, Yeung EH, Vaag A, Bowers K, Liu A, Bao W, Li S, Madsen C, Grunnet LG, Granström C, Hansen S, Martin K, Chavarro JE, Hu FB, Langhoff-Roos J, Damm P, Zhang CL. Growth and obesity through the first 7 years of life in association with levels of maternal glycemia during pregnancy: A prospective cohort study. The American Journal of Clinical Nutrition 2016; 103:794-800. [DOI: 10.3945/ajcn.115.121780; PMID: 26817507].
  125. Li S, Zhu Y, Chavarro JE, Bao W, Tobias DK, Ley SH, Forman JP, Liu A, Mills J, Bowers K, Strøm M, Hansen S, Hu FB, Zhang C. Healthful dietary patterns and the risk of hypertension among women with a history of gestational diabetes mellitus: A prospective cohort study. Hypertension 2016. [DOI: 10.1161/HYPERTENSIONAHA.115.06747; PMID: 27091899]
  126. Cai XY, Li HY, Liu A. A marginal rank-based inverse normal transformation approach to comparing multiple clinical trial endpoints. Statistics in Medicine 2016. [DOI: doi: 10.1002/sim.6928; PMID:26990442]
  127. Wu MX, Shu Y, Li Z, Liu A. Repeated significance tests of linear combinations of sensitivity and specificity of a diagnostic biomarker. Statistics in Medicine 2016. [DOI: 10.1002/sim.6932; PMID: 26947768].
  128. Gee BT, Nansel TN, Liu A. The reduction of hypoglycemic events with a behavioral intervention: A randomized clinical trial for pediatric patients with Type I diabetes mellitus. Diabetic Medicine. (In press).
  129. Lipsky LM, Gee B, Liu A, Nansel TN. Body mass index and adiposity indicators associated with cardiovascular biomarkers in youth with type 1 diabetes followed prospectively. Pediatric Obesity. (In press).
  130. Wang Y, Sun H, Wang H, Liu A. Efficiency of targeted clinical trials with pre-post designs for a binary endpoint. Statistics in Biosciences. (In press).
  131. Foster J, Liu D, Albert PS, Liu A. Identifying subgroups of enhanced predictive accuracy from longitudinal biomarker data using tree-based approaches: applications to fetal growth. Journal of the Royal Statistical Society: Series A. (In press).
  132. Li QZ, Liu A, Xiong WJ. D-optimality of group testing for estimation of correlated rare diseases with misclassification. Statistica Sinica. (In press).
  133. Nansel TR, Lipsky LM, Eisenberg MH, Liu A, Mehta S, Laffel L. Can families eat better without spending more? Effect of improving diet quality on diet cost in a randomized trial among youth with type 1 diabetes and their parents. Journal of the Academy of Nutrition and Dietetics. (In press).
  134. Nansel TR, Lipsky LM, Liu A. Greater diet quality is associated with more optimal glycemic control in a longitudinal study of youth with type 1 diabetes. The American Journal of Clinical Nutrition. (In press).

Books and Book Chapters

  1. Liu A, Schisterman EF. Principal component analysis. In Encyclopedia of Biopharmaceutical Statistics, 2nd ed. 2004
  2. Liu A, Yu KF. Inference following a sequential clinical trial. In Clinical Trials Handbook, Wiley, 2009
  3. Liu A, Liu CL, Yu KF. Group-Sequential methods in biomedical research. In Methods and Applications of Statistics in the Life and Health Sciences. Wiley, 2009
  4. Liu A, Liu CL, Yu KF. Group-Sequential methods in biomedical research. In Encyclopedia of Statistical Sciences. Wiley, 2010
  5. Zou KH, Liu A, Bandos A, Ohno-Machado L, Rockette H. Statistical Evaluation of Diagnostic Performance: Topics in ROC Analysis. Chapman & Hall/CRC, New York, 2011
  6. Chen Z, Liu A, Qu Y, Tang L, Ting N, Tsong Y (editors). Applied Statistics in Biomedicine and Clinical Trials Design: Selected Papers from 2013 ICSA/ISBS Joint Statistical Meetings. Springer, New York, 2015.