A major focus of the Branch is the prevention of MTCT both domestically and internationally. MTCT studies in pregnant women must consider potential effects of in utero drug exposures on the fetus and possible delayed effects in later childhood. Therefore, studies must conduct long-term follow-up of uninfected children who are perinatally exposed to increasingly complex antiretroviral regimens to evaluate for delayed adverse consequences of such exposure.
The MPIDB supports a large portfolio of domestic and international investigator-initiated grants in addition to studies within clinical trials networks the Branch supports, including the NICHD Domestic and International Pediatric and Maternal HIV Clinical Studies Network in collaboration with the International Maternal, Pediatric, Adolescent AIDS Clinical Trials (IMPAACT) Network, observational studies in the Pediatric HIV/AIDS Cohort Study, and through collaborations with the President's Emergency Plan for AIDS Relief (PEPFAR). These projects are pursuing research focused on, but not limited to, the following areas:
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