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Program on Fragile X Syndrome (FXS) and Associated Disorders

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The FXS Research Centers (FXSRC) Program supports multidisciplinary research that will improve the diagnosis of and treatments for FXS and its related conditions, Fragile X Tremor-Ataxia Syndrome (FXTAS) and Fragile X Premature Ovarian Insufficiency (FXPOI). 

In 2014, this program was recompeted as U54 cooperative agreements with funding sources that include the National Institute of Mental Health and the National Institute of Neurological Diseases and Stroke. Three centers were funded under this new mechanism. The FXSRCs stimulate the formation of multidisciplinary, multi-institutional teams with the common goal of facilitating the translation of basic research findings from bench to bedside to community.

Three FXSRCs were initially funded in fiscal year 2003 in response to the Children’s Health Act of 2000 (P.L. 106-310), which provided for the establishment of at least three centers to conduct and support basic and biomedical research into the detection and treatment of FXS.  The Centers were refunded in early fiscal year 2008 and included projects that focused on newborn screening and its impact on the family, improved diagnosis of FXS, and the development of assays to test the efficacy of interventions in murine models of the condition.  

The NIH Research Plan on Fragile X Syndrome and Associated Disorders (PDF - 440 KB) was published in 2009 and outlines research objectives for each of the three Fragile X disorders, FXS, FXTAS, and FXPOI. This plan was revisited in 2012 and those revised objectives formed the basis of the most recent Request for Applications for the FXCRC Program.

For more information on the FXSRCs, visit ​​

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