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Male Reproductive Health

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This program area, directed by Dr. Stuart Moss, supports research on the physiology and pathophysiology of male reproduction. Major areas of scientific interest include:

  • The process of spermatogenesis, including the acquisition of sperm structure and functional characteristics associated with normal fertility, and the result of perturbations in the process due to e.g. advanced age or exposure to environmental factors.
  • The identification and differentiation of spermatogenic stem cells.
  • The role of the epididymis and other components of the reproductive tract in sperm maturation and function.
  • The paracrine and endocrine mechanisms associated with the hypothalamus, pituitary, testes, and reproductive tract needed for successful male reproduction.
  • The genetics of male reproduction, including the identification of genes that are critical for fertility.
  • The epigenetics of male reproduction, including transgenerational inheritance and the identification of environmental factors that may affect the epigenome and be important for normal spermatogenesis, sperm function, and the health of the next generation.
  • Paternal age and its impact on sperm function and the health of the next generation.
  • The study of molecular mechanisms of fertilization, centering on sperm-egg interactions.
  • The translational and clinical aspects of male reproductive biology.
  • The training of investigators in the field of male reproductive health.
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