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Male Reproductive Health

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This Program area, directed by Dr. Stuart Moss, supports research on the physiology and pathophysiology of human male reproduction. Studies in this portfolio focus on the functions of the hypothalamus, pituitary, testes, and reproductive tract needed in the male for successful reproduction and the perturbations in this axis that compromise virilization and fertility. Scientific areas of particular emphasis include:

  • The identification and differentiation of spermatogenic stem cells
  • The acquisition of sperm structure and functional characteristics associated with normal fertility
  • Epigenetic mechanisms important for normal sperm function and transgenerational inheritance
  • Endocrine and paracrine mechanisms governing spermatogenesis
  • Sperm maturation in the reproductive tract in both the male and female
  • Molecular mechanisms of fertilization with an emphasis on sperm-egginteractions,
  • The role of paternal aging in proper sperm function
  • The identification of genes involved in these processes

Additional interest is centered on clinical and translational aspects of male reproductive biology.

Last Reviewed: 09/15/2014
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology