Skip Navigation

2nd International Workshop on Cyclic AMP, Phosphodiesterases, & Human Disease

Skip sharing on social media links

June 8-10, 2011


Program in Developmental Endocrinology and Genetics (PDEGEN), Division of Intramural Research (DIR), NICHD


Building 60 (The Cloisters), NIH Main Campus; Bethesda, Maryland


Phosphodiesterases (PDEs) are unique molecules that bind to cyclic Adenosine Monophosphate (cAMP), which is involved in multiple biochemical processes, such as the regulation of metabolism, and Guanosine Monophosphate (GMP), which is found in RNA. Some of the most successful drugs on the market today affect PDE function. Recently, mutations in PDE genes were identified in human genetic diseases, and researchers found that PDEs had a potential role in predisposition to tumors and/or cancer. Studies of PDEs in mouse models point to a variety of developmental effects, from heart function to reproduction. This workshop aims to:

  • Bring together PDE and cAMP experts from a variety of disciplines, including: endocrinology, pharmacology and biochemistry, dietary medicine, reproductive science, and cancer.
  • Discuss refocusing research on PDEs to a more translational approach , and identify genetic components of the activity of PDEs that may affect disease susceptibility in many systems.
  • Identify pharmacological and/or dietary supplement compounds that could enhance or inhibit activity in tissues that were not known previously to be affected.

Attendance at the workshop is by invitation only.


Dr. Constantine Stratakis, PDEGEN, DIR, NICHD
Tel: 301-402-1998

Last Reviewed: 11/30/2012
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology