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Hypoxic Ischemic Encephalopathy (HIE): Opportunities & Challenges

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August 9-10, 2010


Pregnancy and Perinatology (PP) Branch, Center for Developmental Biology and Perinatal Medicine (CDBPM), NICHD; Office of Rare Diseases (ORD), NIH


Pooks Hill Marriott, Bethesda, Maryland


HIE occurs following acute perinatal asphyxia in approximately 0.5-1.0 per 1,000 infants. There have been no interventions which have successfully improved outcome (death and disability) until the recent advent of cooling therapy. In the past four years, several large trials, using head cooling and whole body hypothermia, have shown promising results with improvement in both rates of death and moderate to severe disability in survivors.

The goals of this meeting are to:

  • Review basic and clinical evidence for hypothermia as a treatment for HIE including recently completed trials as well as the animal literature.
  • Identify gaps in knowledge and future research directions by experts in the field.
  • Discuss the implementation of hypothermia therapies for infants with HIE, focusing on specific, practical aspects of patient care, follow up, and centralized registries.

The scope of the meeting will include a review of the basic and clinical information available for hypothermia treatment. In addition, an agenda on the impact of implementation of hypothermia therapies for infants with HIE will be discussed, focusing on specific, practical aspects of patient care, follow up and centralized registries. Experts in the field will be invited to discuss available evidence or research and identify research needs for translation of the research findings into clinical practice.


Dr. Rosemary Higgins, PP Branch, CDBPM, NICHD
Tel: (301) 435-7909

Last Reviewed: 11/30/2012
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