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Gordon Research Conference on Mutagenesis

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July 20-25, 2008


Mutagenesis plays a central role in our lives. A low level of mutagenesis is advantageous, and ensures the survival of species by promoting evolution. Programmed mutagenesis of immunoglobulin genes promotes diversity and provides a dynamic defense against invading pathogens. However, many human diseases, including most cancers, arise as a consequence of mutations that occur either spontaneously, or are induced by environmental chemical/physical mutagens. Accumulation of oxidative lesions as a result of normal metabolism has been implicated in premature aging and neurodegeneration. Mutagenesis also drives the evolution of virulent bacterial and viral pathogens, allowing them to evolve resistance to therapeutics and thwart the immune response.

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Last Reviewed: 11/30/2012
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology