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NIH/ACC 2001 Scientific Conference Agenda Potential Cellular & Molecular Mechanisms in Autism & Related Disorders

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Sponsored by NICHD and NIEHS, NIMH, NINDS, NIDCD, and the Office of Rare Diseases

September 6-7, 2001

Bethesda Marriott, Bethesda, Maryland

September 6, 2001

8:30 - 9:00 a.m. Welcome & Introductions
NIH Directors

Duane Alexander, NICHD
Kenneth Olden, NIEHS
Steven Hyman, NIMH
Audrey Penn, NINDS
James Battey, NIDCD

Conference Co-Chairs

Jean Lauder, University of North Carolina
Marie Bristol Power, NICHD
Cindy Lawler, NIEHS

Autism and Related Disorders

8:50 - 9:00 a.m. Overview
9:00 -10:20 a.m.

Session 1: Neuropathology of Autism: Chair, Anthony Bailey
Neuroanatomical Correlates of Autism
Anthony Bailey

Dysregulation of Reelin Protein in Autism
S. Hossein Fatemi

Cerebellar Neuropathology and Autistic Behaviors: Exploration of a Mouse Model System
Daniel Goldowitz

Reduced Number of Benzodiazepine Binding Sites and Decreased Density of GABAA Receptors in Hippocampal Formation of Autistic Individuals
Gene J. Blatt

10:20 - 10:35 a.m. Discussion
10:35-10:50 a.m. Coffee Break
Sponsored by the ASA Foundation
10:50 - 11:30 a.m.

Session 2: Cognitive and Social Phenotypes in Autism: Chair, Joseph Piven

Human Research

Social Intelligence in Normal and Autistic Brain
Helen Tager-Flusberg

fMRI Evidence for Differences in Social Affective Processing in Autism
Robert Schultz

11:30 - 11:45 a.m. Discussion
11:45 - 1:00 a.m. Working Lunch
1:00 - 2:00 a.m.

Animal Models
Social Interaction Abnormalities in Mice Lacking Dvl1
Anthony Wynshaw-Boris

Social Deficits in Oxytocin Knockout Mice
Larry Young

The Primate Temporal Lobe Structures: Maturation, Early Dysfunction, and Relationships to Human Developmental Disorders
Jocelyne Bachevalier

2:00 - 2:15 p.m. Discussion
2:15 - 3:15 p.m.

Session 3: Molecular Genetics of Autism: Chair, Edwin Cook

Functional and Positional Candidate Gene Studies of Autism
Edwin Cook

Evidence Supporting Wnt2 as an Autism Susceptibility Gene
Thomas Wassink

Rett Syndrome, MECP2 Mutations, and Autism
Ignatia Van den Veyver

3:15 - 3:30 p.m. Break
3:30 - 4:30 p.m.

Cellular Substrates of Fragile X Syndrome
William T. Greenough

Brain Abnormalities in a Mouse Model for Smith-Lemli-Opitz Syndrome: Implications for Autism
Heather Baudet and Kathy Sulik

Ch 15q 22-23 Deletion in Autism and Evidence for Location of Two Series of Chromosome 15 Specific Duplicons that Predispose to Chromosome Rearrangements
Moyra Smith

4:30 - 4:45 p.m. Discussion
4:45 - 5:00 p.m. General Discussion
6:30 p.m. Working Dinner (Session chairs and speakers only - reports)

September 7, 2001

8:00-9:40 a.m.

Session 4: Neurotransmitters Systems in Autism: Chair, Jean Lauder

Abnormal Serotonin Synthesis and GABAA Receptors Measure with PET in Autistic Children
Diane C. Chugani

Prenatal Serotonin in Rats as an Animal Model of Autism
Patricia Whitaker-Azmitia

Chronic Elevation of Serotonin and Norepinephrine in MAO-A and MAO-A/B Deficient Mice
Daniel Holschneider

Control of Central Serotonergic Neuron Phenotype by the ETS Domain Factor PET-1
Evan Deneris

Characteristics of Mice Lacking the gabrb3 Gene
Timothy DeLorey  

9:40 - 9:55 a.m. Discussion
9:55 -10:10 a.m. Break

Role of the Environment in Autism

10:10 - 12:10 a.m.

Session 5: Environmental Influences as Etiologic Factors in Autism: Chair, Stanley Barone

Developing Neurotransmitter Systems as Targets for Pesticide Exposure
Jean Lauder

Environmental Insults and Early Developmental Genes in Autism Etiology
Patricia Rodier

Regulation of Neurogenesis by Growth Factors and Neurotoxicants
Emanuel DiCicco-Bloom

Disruption of Synaptic Neural Cell Adhesion Molecules by Environmental Insults
Kenneth Reuhl

Multidisciplinary Analysis of the BDV Animal Model of Autism: Neuroanatomical, Neurochemical, Behavioral, and Genetic Features
Mikhail Pletnikov

Possible Environmental Risk Factors in the Etiology of Autism
Isaac Pessah

12:10 - 12:25 a.m. Discussion
12:25 - 1:20 a.m. Working Lunch
Sponsored by the Autism Tissue Program

Emerging Technologies and Strategies in Autism Research

1:20 - 2:40 p.m.

Session 6: Emerging Technologies: Chair, Clarence Schutt

Gene-based Mutagenesis for Functional Annotation in the Mouse
Terry Magnuson

Jeremy Nicholson

Microdissection and Laser Capture Micromanipulation
Chi'ming Huang

Structural Biology in Autism Research
Clarence Schutt

2:40 - 2:55 p.m. Discussion
2:55 - 3:10 p.m. Coffee Break
Sponsored by the National Association for Autism Research (NAAR)
3:10 - 4:00 p.m.

Session 7: Autism Brain Tissue Panel-Progress and Future Strategies: Chair, Jane Pickett

Brain and Tissue Donation - Issues Related to Children
Ronald Zielke

Margaret Bauman

Microarrays in Human Tissue/Tuberous Sclerosis/Seizures
Peter Crino

Tissue Based Data Warehousing to Maximize Collaboration by Divergent Laboratories
Harry Haroutunian

Robert Lopez

4:00 - 4:15 p.m. Discussion
4:15 - 4:40 p.m. Reports of Recommendations from Working Groups
4:40 - 5:00 p.m. Discussion of Reports from Working Groups

We would like to thank Jack Bishop, William McMahon, and Ute Schambra for serving as conference discussants

We would like to thank the Autism Tissue Program, The National Association for Autism Research (NAAR), and the ASA Foundation for sponsoring the refreshments for this conference.

Last Reviewed: 11/30/2012
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology