Workshop

February 14-15, 2011

Workshop Organizers

*co-chair

  • *Kjersti Aagaard-Tillery, M.D.—Baylor College of Medicine
  • *Kent L. Thornburg, Ph.D.—Oregon Health & Science University
  • Ira M. Bernstein, M.D.—University of Vermont
  • David A. Washburn, Ph.D.—Georgia State University

Background

From a life-course perspective, although we know that influences in early development can have long-term health impacts, we still have much to learn about the specific factors and mechanisms related to the developmental origins of health and disease and the markers for these phenomena. Key to this knowledge is understanding how specific genetic, biological, environmental, behavioral, and social factors interact over time to influence health and disease susceptibility, particularly in a developing organism and through epigenetic mechanisms. Such an understanding can help to prevent child and adult disease, prevent and reduce disability, and promote lifelong health and habilitation.

As examples, discussions of this theme could include:

  • Examining epigenetic, meta-genomic, and other molecular mechanisms in relation to a wide range of physiological, therapeutic, behavioral, social, and other environmental exposures and interactions across development and generations
  • Understanding the impact of specific exposures, during the course of development, on subsequent health, disease, and disability outcomes, including the mechanisms through which these exposures influence subsequent outcomes and the impact of nutrition over the life course
  • Identifying the appropriate bio- and other markers for the developmental origins of specific conditions that can be used to help identify points of intervention and to monitor health and functional outcomes
  • Determining how best to apply and translate findings into novel ways to prevent, reverse, or otherwise treat specific conditions, prevent adverse health outcomes, or prevent or reduce disability
Questions? Email us at NICHDvision@mail.nih.gov
Last Updated Date: 05/23/2011
Last Reviewed Date: 05/23/2011