The GPN, funded through the NICHD’s Pregnancy and Perinatology Branch (PPB), was established in 2005 to concentrate on the most common form of preterm birth—spontaneous preterm delivery following the premature onset of labor—at a stage of pregnancy associated with the highest mortality and morbidity rates for the infant, that is, at less than 34 weeks of gestational age.
The goal is to study the genetic and environmental causes and mechanisms of spontaneous preterm birth to understand why and how a mother’s body goes into labor prematurely. Using state-of-the-art genome-wide association studies and protein profiling, the GPN hopes to identify new biomarkers of and find molecular mechanisms responsible for preterm birth to better predict spontaneous preterm birth and design prevention and treatment strategies.
The GPN has completed recruitment into three studies:
GPN has completed recruitment in these studies, and it is now conducting specimen and data analyses.
Following publication of results from the GPN, the genomic and proteomic data will be placed in anonymized databases for data mining by the research community. Any remaining samples will become available to the research community for further research into preterm birth.
Parry S; et al. Maternal Serum Serpin B7 Is Associated With Early Spontaneous Preterm Birth. Am J Obstet Gynecol. 2014 Jun 19. PMID24954659.