TBI is a leading cause of death and disability in children and adults. Improvements in treatment and care have increased survival rates for those with TBI, while also increasing the rates of TBI patients with persistent physical, cognitive, behavioral and social deficits. Despite dramatic increases in our understanding of TBI during the past two decades, there is still much to learn about this complex condition.
The NICHD’s National Center for Medical Rehabilitation Research (NCMRR) established the TBI-CT Network in 2002 to conduct multicenter observational studies and clinical trials of patients with TBI. The overarching goal of the network is to:
Researchers in the TBI-CT Network are still conducting data analyses and other activities related to Network studies, but the Network itself is not currently receiving additional NICHD funding.
The TBI-CT Network included research teams at eight sites and a Data Coordinating Center (DCC). Staff from the NCMRR’s Traumatic Brain Injury (TBI) and Stroke Rehabilitation (TSR) Program provided scientific oversight for the Network.
One of the primary activities of the TBI-CT Network was to create a working definition of TBI. In addition, the Network aimed to:
Other research topics studied through the TBI-CT Network included (but were not limited to):
In addition, Network researchers initiated and successfully enrolled patients in the Citicoline Brain Injury Trial (COBRIT) to evaluate the effect of 90 days of citicoline on the functional outcomes of patients with complicated mild, moderate, and severe TBI. Citicoline, a compound found throughout the body, offers potential neuroprotective properties as well as facilitating neurorepair post injury. Citicoline was approved for use in TBI in 59 countries. COBRIT is a two-arm, double-blind, placebo-controlled, phase III, multicenter trial that employs stringent neuroimaging and clinical criteria to assure accurate enrollment. Functional outcomes are assessed at 30, 90, and 180 days after injury. A corollary study is evaluating the role of genetic markers to establish a TBI genetics database. Analysis of data from COBRIT and the related study are currently underway; findings will be published once the analysis is complete. For more information on COBRIT, visit http://www.ncbi.nlm.nih.gov/pubmed/19803786.
The TBI-CT Network no longer receives funding, but data analysis activities are ongoing. Funded clinical sites within the Network included:
Columbia University served as the DCC for the Network.