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Video Text Alternative: Meet Our Researchers: Dr. Reijo Pera on timing and rating embryos in IVF

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Meet Our Researchers

Dr. Reijo Pera describes the developmental steps they look for in rating embryos

NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development logo
GRAPHIC SLIDE: Renee A. Reijo Pera, Ph.D.

Dr. Reijo Pera on camera.
Dr. Reijo Pera: We published a paper in Nature Biotechnology in 2010. It was really a culmination of almost a decade of work.
Camera Cut.

Dr. Reijo Pera on camera.
Dr. Reijo Pera: You can see more things, so, and you can capture it on film. So what we did is, if you want to just run through the human embryo development, the sperm and the egg come together and you get the first cell is called a zygote. That cell will begin to divide into two, and when it begins to divide into two, at the time that you see a waist until you get two cells should be just 15 plus or minus 5 minutes. If an embryo is going to make it, it will do this very cleanly and very quickly. Embryos that are going to ultimately arrest or not make it developmentally, they’ll sometimes move around more, they’ll take longer in cytokinesis, or they will instead of going one to two cells, they’ll go one to three cells. And then once the embryo has formed two cells, it should just be 11 hours plus or minus 4 hours until you see the third cell. And then the third and the fourth cells should appear simultaneously.

Why I’m telling you this is, you could imagine that you might be able to see these things if you just walked into the lab and looked at the embryo occasionally, but it's much easier to measure those precise intervals if you have a movie that you can actually look at. And more importantly, we've written computer software that allows us to automatically track the process of the embryo going from one cell to two and two to four.
Last Updated Date: 12/18/2013
Last Reviewed Date: 12/18/2013
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