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Vulvodynia: Research Activities and Scientific Advances

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Vulvodynia is a common problem among women, and the pain associated with this disorder can cause not only great physical anguish but also emotional distress. In the absence of effective treatments that can be applied widely, it is important that researchers gain a greater understanding of the disease's causes, develop better treatments, and, if possible, learn how to prevent vulvodynia altogether.

The NICHD conducts and supports research in a variety of areas related to vulvodynia, from basic science to clinical research.

Institute Activities and Advances

The Research Plan on Vulvodynia (PDF - 681 KB), developed by the NICHD in collaboration with other federal, private, and nonprofit agencies and researchers in the field, lays out an agenda for the rigorous scientific research needed to answer questions and fill in knowledge gaps about vulvodynia. The agenda builds on ongoing vulvodynia research and seeks to advance the field by enhancing capacity for conducting research related to vulvodynia. In addition, the plan aims to apprise the research community of scientific goals for vulvodynia research and to foster collaborations among agencies and organizations interested in the topic.

The Gynecologic Health and Disease Branch (GHDB) and the Fertility and Infertility (FI) Branch lead the Institute's research initiatives relative to vulvodynia. Research currently supported by these Branches includes the following initiatives:

  • Researchers are conducting a randomized, controlled trial of the drug gabapentin, which is currently used to control epileptic seizures, to treat pain among women with provoked vestibulodynia (PVD), a type of localized vulvar pain. Researchers selected this medication to study because of its efficacy in treating other neuropathic pain conditions and the promising data on its use in PVD.
  • A long-term, population-based study of genetic and hormonal influences on the occurrence and remission of vulvodynia, involving 2,500 women, is examining whether women with vulvodynia have an increased prevalence of one or more genetic polymorphisms that are associated with pain, and whether the risk of vulvodynia is influenced by the use of exogenous hormones, such as oral contraceptives and hormone therapy. The researchers recently found that women with vulvodynia are more likely than other women to also have another chronic pain condition, such as fibromyalgia, interstitial cystitis, or irritable bowel syndrome. Another recent finding showed that vulvodynia is a common condition among women in Detroit, but that most have never sought treatment and even fewer have been diagnosed.
  • A study of immune system factors and vulvodynia risk suggests that vulvodynia may result from an altered immune-inflammatory response mechanism that is a consequence of reproductive, gynecologic, environmental, or psychological exposures. Researchers are testing whether the first three of these exposures or psychological trauma and morbidity influence the odds of having vulvodynia. They are also examining markers of immuno-inflammation and the proliferation of nerve fibers.
  • Researchers are using a mouse model of vestibulodynia, the most common form of vulvodynia, to examine neural consequences of vestibular inflammation as well as the effect of estrogen on neuronal activity. The study will also assess the role of the angiotensin II receptor type 2, a potential therapeutic target for vulvodynia.
  • Investigators leading a study of methods of evaluating and classifying pelvic pain are assessing the physiology of pain in disease states and characterizing the psychological determinants of the pain experience. Having valid measures of pain in the pelvic floor will allow the rational application of a variety of treatments, such as physical therapy, medications, cognitive-behavioral therapy, and injections of botulinum toxins.
  • Currently, the diagnosis of vulvar vestibulitis syndrome, the most common form of vulvodynia, relies on rather crude measures, such as using a cotton swab to apply gentle pressure to various vulvar sites and relying on the patient's own reports of pain. NICHD-supported research aims to refine the diagnosis of chronic vulvar pain by establishing the reliability and reproducibility of quantitative assessment tools to evaluate vulvodynia.

The NICHD's Division of Intramural Research also contributes to vulvodynia research through research conducted through several units in the Program in Reproductive and Adult Endocrinology. These include studies on the underlying physiology, diagnosis, and treatment of reproductive disorders.

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Other Activities and Advances

  • On July 11 and 12, 2011, the NICHD and the NIH Office of Research on Women’s Health (ORWH) sponsored a meeting, Vulvodynia: A Chronic Pain Condition-Setting a Research Agenda, to continue focused efforts to understand vulvodynia. More than 75 researchers and members of organizations and agencies interested in the condition took part. This meeting was a key part of the process for developing the NIH Research Plan on Vulvodynia (PDF - 745 KB).
  • The NICHD participates in the NIH Pain Consortium, a multidisciplinary, trans-NIH effort to advance the agenda of pain research.
  • In 2007, the NICHD joined the NIH ORWH, the National Institute of Neurological Disorders and Stroke, the NIH Pain Consortium, and other partners to establish the Vulvodynia Awareness Campaign. The campaign aimed to raise awareness among women and health care providers about the condition to help improve care for women with vulvodynia.

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Last Updated Date: 04/28/2014
Last Reviewed Date: 04/22/2013
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