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How many people are affected by or at risk of Rett syndrome?

Current estimates suggest that Rett syndrome occurs in one out of every 10,000 to 15,000 girls born and affects 1 in 10,000 to 22,000 females in the U.S.1,2,3


  1. Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H.Y. (1999). Rett syndrome is caused by mutations in X-linked MECP2. Nature Genetics, Oct;23(2), 185–188. [top]
  2. Zoghbi, H. Y. (2005). MeCP2 dysfunction in humans and mice. Journal of Child Neurology, 20, 736–740. [top]
  3. RD. (2012). Prevalence and incidence of Rett's syndrome. Retrieved June 21, 2012, from http://www.rightdiagnosis.com/r/retts_syndrome/prevalence.htm#prevalence_intro [top]

Last Updated Date: 11/30/2012
Last Reviewed Date: 11/30/2012
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