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Primary Ovarian Insufficiency (POI): Research Activities and Scientific Advances

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The causes of POI are still little understood. Although many of its symptoms can be treated successfully, infertility is unavoidable in most women with POI. Understanding more about the complex biology behind the condition will help scientists as they work to devise more effective ways to treat symptoms and, ultimately, to prevent the condition from developing. The NICHD conducts and supports research on genes, hormones, and other contributory factors in its push to improve understanding and make further headway against POI.

Institute Activities and Advances

Researchers in the NICHD’s Division of Intramural Research (DIR) are studying genetic factors that are known to cause or contribute to POI. NICHD researchers in the Program in Reproductive and Adult Endocrinology (PRAE) and those funded by the NICHD have identified several genes more common in women with POI than in women who do not have the disorder. One of these genes is FMR1, mutations in which are known to cause Fragile X syndrome; certain mutations in this gene have been linked to Fragile X-Associated POI (FXPOI). Other genes being investigated are BMP15, DAZL, and FOXO3.

Researchers are also investigating the causal role of autoimmunity in POI. Researchers in the NICHD’s Section on Epigenetics and Development compared women with and without POI. They discovered that several autoimmune diseases were more common among women with POI, especially if they also had Turner syndrome. The findings suggest that factors contributing to the ovarian insufficiency seen in POI also might play a role in autoimmunity.

PRAE researchers also identified a potential target of the autoimmune response that causes some cases of POI and were able to slow the immune system attack on the ovaries in mice with POI. For details on this finding, visit NIH Researchers Slow Immune Attack on Ovaries in Mice.

Other research supported by the Fertility and Infertility (FI) Branch has addressed issues related to eggs, their quality, and their quantity in POI, as well as ways to save the eggs as a way to preserve fertility. FI Branch research also examines various methods of assisted reproductive technology and their effectiveness.

In addition to the physical components of POI, the NICHD aims to reveal new evidence about the emotional aspects of the disorder so that health care providers can offer appropriate psychological support to women with POI. PRAE research has shown that women with POI are much more likely than other women to experience depression at some point during their lives.1 Future studies will investigate whether hormonal changes, perhaps combined with a particular genetic makeup, might predispose some women to depression and anxiety.

PRAE research also showed that two-thirds of women were dissatisfied with the way they received their POI diagnosis from their health care provider. In addition, research has pointed to the positive role spirituality plays in patients’ ability to cope with their diagnosis and suggest therapeutic avenues for reducing emotional suffering.2

Other Activities and Advances


  1. Schmidt, P. J., Luff, J. A., Haq, N. A., Vanderhoof, V. H., Koziol, D. E., Calis, K. A., et al. (2011). Depression in women with spontaneous 46, XX primary ovarian insufficiency. Journal of Clinical Endocrinology and Metabolism, 96, E278-E287. [top]
  2. Ventura, J. L., Fitzgerald, O. R., Koziol, D. E., Covington, S. N., Vanderhoof, V. H., Calis, K. A., et al. (2007). Functional well-being is positively correlated with spiritual well-being in women with spontaneous premature ovarian failure. Fertility and Sterility, 87, 584-490. [top]
  3. Cooper, A. R., Baker, V. L., Sterling, E. W., Ryan, M. E., Woodruff, T. K., & Nelson, L. M. (2010). The time is now for a new approach to primary ovarian insufficiency. Fertility and Sterility, 95, 1890–1897. [top] 

Last Updated Date: 06/26/2013
Last Reviewed Date: 04/12/2013
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