The first sign of POI is usually menstrual irregularities or missed periods,1 which is sometimes called amenorrhea (pronounced ey-men-uh-REE-uh or uh-men-uh-REE-uh).
In addition, some women with POI have symptoms similar to those experienced by women who are going through natural menopause, including:
For many women with POI, trouble getting pregnant or infertility is the first symptom they experience and is what leads them to visit their health care provider. This is sometimes called “occult” (hidden) or early POI.4
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