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Osteogenesis Imperfecta (OI): Other FAQs

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Basic information for topics, such as “What is it?” and “How many people are affected?” is available in the Condition Information section. In addition, Frequently Asked Questions (FAQs) that are specific to a certain topic are answered in this section.

Can OI lead to cancer?

Studies comparing people with and without OI have found no differences in cancer risks between the two groups.

What if I have OI and want to get pregnant?

OI does not affect fertility. However, about one-half of women with OI give birth by cesarean section. This is because they often have pelvic bone abnormalities that prevent vaginal birth. Women with OI also are more likely to have infants who present in the breech position (feet first).1

Women who have OI, have partners with OI, or have already had a child with OI should consider genetic counseling. A genetic counselor is a health care professional who understands the risks of having an infant with OI and can explain prenatal tests that can identify this disorder so that the family can provide care.


  1. Cubert, R., Cheng, E. Y., Mack, S., Pepin, M. G., Byers, P. H. (2001). Osteogenesis imperfecta: Mode of delivery and neonatal outcome. Obstetrics & Gynecology, 97, 66–69. [top]

Last Updated Date: 03/06/2014
Last Reviewed Date: 12/16/2013
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology