NICHD and NICHD-Sponsored Resources
The NICHD supports and maintains a number of valuable research projects and networks that are useful to neuroscientists and researchers. Some of these resources include:
The NICHD supports and maintains a number of valuable research projects and networks that are useful to neuroscientists and researchers. Some of these resources are listed below. For a complete list, visit Neuroscience Research Resources.
- DS Connect™: The Down Syndrome Registry
This patient registry is a secure, Web-based national resource for storing and sharing demographic and health information about individuals with Down syndrome. The Registry will help identify those people with Down syndrome who might be eligible to take part in research studies or clinical trials and connect them with the researchers leading those studies.
- Cincinnati Magnetic Resonance Imaging of Neurodevelopment (C-Mind) Project
This project aims to create standardized methods for recruiting, scanning, and processing data using functional magnetic resonance imaging (fMRI) coupled with arterial spin labeling perfusion and to investigate language development and attention brain processes of typically developing children using task fMRI. Software, manuals, and raw and processed data will be available to the scientific community. The C-Mind Project is led by the Pediatric Neuroimaging Research Consortium at Cincinnati Children’s Hospital Medical Center in collaboration with the laboratory of Neuroimaging at the University of California, Los Angeles.
- Intellectual and Developmental Disabilities Research Centers (IDDRCs)
This program provides core infrastructure and research support for investigators with independently funded projects to understand the causes of intellectual and developmental disabilities as well as their prevention, management, and treatment through biomedical and behavioral approaches. There are currently 15 IDDRCs at universities and children’s hospitals throughout the country. Several IDDRCs also house Fragile X Syndrome Research Centers or their affiliated sites, thus serving as a focus for Fragile X-related basic, clinical, and translational research.
- Jackson Laboratories Cytogenetic Models Resource
This resource maintains and distributes chromosome aberration stocks, which provide primarily mouse models for Down syndrome research.
- Medical Rehabilitation Research Infrastructure Network
This network of centralized research infrastructure assists young faculty at the formative stage of their careers. Seven centers across the country provide state-of-the-art research facilities, mentorship, pilot grants, and other opportunities particularly relevant to rehabilitation researchers. The network offers a broad range of expertise, including molecular/cellular biology, muscle physiology and function, biomechanical modeling, bioengineering and robotics, outcomes measures, analysis of large administrative and research datasets, and translation and commercialization of research.
- Newborn Screening Translational Research Network (NBSTRN)
The mission of the NBSTRN is to improve the health outcomes of newborns with genetic or congenital disorders by means of an infrastructure that allows investigators access to robust resources for newborn screening research.
- NICHD Brain and Tissue Bank for Developmental Disorders
This human tissue repository, located at the University of Maryland, Baltimore, provides resources to investigators who seek to advance research on developmental disorders. This tissue repository systematically collects, stores, and distributes brain and other tissues for research dedicated to the improved understanding, care, and treatment of individuals with developmental disabilities, including autism spectrum disorders.
- Xenbase: Xenopus Biology and Genomics Resource
Xenbase is an online resource for information about Xenopus biology, genomics, and the research community using this model organism.
Trans-NIH Sponsored Resources
In addition to resources primarily supported by NICHD, the NICHD contributes to other NIH resources related to the neurosciences. Selected resources are included below. Visit Neuroscience Research Resources for a complete list.
- Biomedical Informatics Research Network (BIRN)
The Biomedical Informatics Research Network (BIRN) is a geographically distributed virtual community of shared resources offering tremendous potential to advance the diagnosis and treatment of disease.
- Center for Inherited Disease Research (CIDR)
CIDR provides high-quality next-generation sequencing and genotyping services, as well as statistical genetics consultation, to investigators working to discover genes that contribute to common disease.
- Knockout Mouse Phenotyping Program (KOMP2)
KOMP2 provides broad, standardized phenotyping of a genome-wide collection of mouse knockouts generated by the International Knockout Mouse Consortium, funded by the NIH, the European Union, the Wellcome Trust, Canada, and the Texas Enterprise Fund.
- Mammalian Gene Collection (MGC)
The MGC provides full-length, open reading frame clones for human and mouse genes that are available for distribution to the scientific community.
- Model Organisms for Biomedical Research
This website provides information about national and international activities and major resources that are being developed to facilitate biomedical research using animal models, such as fruit fly, zebrafish, frog, mouse, and rat.
- MRI Study of Normal Brain Development
This multisite longitudinal study uses technologies like anatomical MRI, diffusion-tensor imaging [DTI], and magnetic resonance spectroscopy [MRS]) to map pediatric brain development. More than 500 children, ranging from infancy to young adulthood, were enrolled in the study. Clinical/behavioral assessment data and raw and volumetric brain MR data are available for download to researchers.
- National Database for Autism Research (NDAR)
The NDAR is an informatics platform for Autism Spectrum Disorders (ASDs). The platform includes relevant data at all levels of biological and behavioral organization, including molecules, genes, neural tissues, and social and environmental interactions, and for all data types, such as text, numeric, image, time series. The NDAR was developed to share data across the entire ASD field and to facilitate collaboration among laboratories and interconnectivity with other platforms.
- Therapeutics for Rare and Neglected Diseases (TRND)
The NIH TRND program is a congressionally mandated program designed to bridge the gap that often exists between basic research discoveries and testing of new drugs in humans. The work of the TRND program includes the discovery, optimization, and preclinical testing of therapies, with the ultimate goal of generating enough sufficient-quality data to support successful investigational new drug applications to the U.S. Food and Drug Administration, and in first-in-human studies (if necessary). The program aims to encourage biotechnology and pharmaceutical companies to take the therapeutic clinical candidate that reach this stage into clinical development.
- Xenopus Gene Collection (XGC)
The XGC supports the production of cDNA libraries, clones, and sequences to provide a set of full-length, open reading frame sequences and cDNA clones of expressed genes for Xenopus. All resources are publicly available for the biomedical scientific community.
- Zebrafish Gene Collection (ZGC)
The ZGC supports the production of cDNA libraries, clones, and sequences to provide a set of full-length, open reading frame sequences and cDNA clones of expressed genes for zebrafish. All resources are publicly available for the biomedical scientific community.
Neuroscience researchers and other scientists may find the following informational resources helpful.
- NIH Research Portfolio Online Reporting Tool Expenditures and Reports (RePORTER)
Like its predecessor CRISP, RePORTER is a database of funded projects that allows users to locate and view NIH awards using their own search criteria. RePORTER provides detailed budget information, research results, and products, including patents and publications. Data from 1985 to the present are available and searchable.
- NIH Common Fund
Developed with input from meetings with more than 300 nationally recognized leaders in academia, industry, government, and the public, the NIH Common Fund provides a framework of the priorities the NIH as a whole must address in order to optimize its entire research portfolio. The NIH Common Fund identifies the most compelling opportunities in three main areas: new pathways to discovery, research teams of the future, and re-engineering the clinical research enterprise.
- NIH Toolbox for Assessment of Neurological and Behavioral Function
The toolbox is a set of standard measures for assessing neurological and behavioral function in clinical studies. The NIH Toolbox generates data that can be used in and compared across diverse clinical studies.
- A series of articles published in a special issue of Neurology describes the tests within the Toolbox, how the Toolbox was constructed and validated, and efforts to establish norms for Toolbox data.
- The NIH Toolbox Resources page includes a complete list of NIH Toolbox measures and a Summary of NIH Toolbox.
- Visit the Demonstration Video page to view the administration of NIH Toolbox measures.
- The Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC)
NITRC now offers a cloud-based computing environment to help researchers manage and analyze large volumes of brain imaging data. With NITRC-CE, an analysis that would typically require 24 hours can be done in less than 10 minutes, for a nominal fee.
- The Neuroscience Information Framework (NIF)
The NIF is a dynamic inventory of Web-based neuroscience resources: data, materials, and tools accessible via any computer connected to the Internet. An initiative of the NIH Blueprint for Neuroscience Research, NIF advances neuroscience research by enabling discovery and access to public research data and tools worldwide through an open-source, networked environment.
Please note: Links to organizations and information included on this page do not indicate endorsement from the NICHD, NIH, or HHS.