Neuroscience: Clinical Trials

The NICHD conducts and supports a variety of clinical research related to neuroscience. Select a link below to learn more about these projects.

Featured NICHD Clinical Trials related to neuroscience:

• Botulinum Toxin for Pelvic Pain in Women With Endometriosis This study is examining if botulinum toxin injections into the pelvic floor muscles can decrease pain and spasms in women with pelvic pain.
• Testing and Calibration of Non-Invasive Optical Imaging Technology for Functional Brain Imaging This study will examine the capabilities of non-invasive functional near infrared imaging techniques on healthy volunteers and compare the results with the existing outcomes of functional magnetic resonance imaging.
• Home-Based Automated Therapy of Arm Function After Stroke Via Tele-Rehabilitation Constraint-Induced Movement therapy, also known as CI therapy, is an approach for rehabilitating use of the more-affected arm in individuals more than one year after stroke with mild to moderate motor impairment. The purpose of this project is to develop and test a method for automating the delivery of this efficacious treatment in a way that the therapy can be provided in stroke patients’ homes.
• Methylphenidate (Ritalin) and Memory/Attention in Traumatic Brain Injury (TBI) This is a two-by-two design with medication (methylphenidate/placebo) and cognitive therapy (Memory and Attention Training [MAAT] or an Attention control intervention) as possible interventions. Using a randomized, placebo-controlled, double-blind design, 200 individuals with persistent cognitive deficits 6 to 12 months after MTBI will be randomized to receive a six week trial of either (1) MAAT and placebo, (2) MAAT and methylphenidate (0.3 mg/kg BID), (3) attention control intervention and methylphenidate (0.3 mg/kg BID), or (4) attention control intervention and placebo.
• Interventions for Children With Attention and Reading Disorders (ICARD) The objective of this randomized clinical trial is to address unanswered questions about the relative effectiveness of treatments for children with both Attention Deficit Hyperactivity Disorder (ADHD) and significant reading difficulties (RD). The study evaluates attentional and word reading outcomes for students with both conditions when provided with either (a) disorder-specific ADHD treatment (carefully managed stimulant medication + parent training), (b) disorder-specific RD treatment (intensive, individualized reading instruction), or (c) the combination of ADHD and RD treatment.
• Memantine Treatment in Fragile X-Associated Tremor/Ataxia Syndrome The purpose of this study is to determine if memantine is effective in treating symptoms of Fragile X-associated Tremor Ataxia Syndrome.
• Psychosocial Adjustment of Adolescents With Spina Bifida (CHATS)
The purpose of this longitudinal study is to evaluate a model of psychological adjustment in young adolescents with spina bifida. The proposed study will be the first to collect observed peer interaction data (target child with close friend) in adolescents with spina bifida. The degree to which neuropsychological limitations experienced by children with spina bifida contribute to their social difficulties and other psychological problems will also be examined. Participants will include a sample of 140 children and young adolescents with spina bifida (with meningomyelocele and shunted hydrocephalus) along with their parents, a close friend, teachers, and health professionals. Questionnaire, interview, neuropsychological testing, and observational methods will be employed during home visits. Findings of this study will provide information on the relevance of family relationships, peer relationships, neuropsychological factors, and biological factors for adjustment in adolescents with spina bifida.

NICHD Clinical Trials

• All NICHD Clinical Trials related to neuroscience

ClinicalTrials.gov Search Results

• All ClinicalTrials.gov Trials related to neuroscience