The goal of treatment for hypoparathyroidism is to restore the body’s calcium, magnesium, and phosphorus levels in the blood and urine to normal levels. This may be challenging, especially with conventional therapy.
The only therapies that are approved by the Food and Drug Administration (FDA) for hypoparathyroidism (from any cause) are synthetic forms of vitamin D and calcium and magnesium supplements.
Hypoparathyroidism is one of the few hormone deficiency diseases that are not usually treated with the missing hormone. However, greater availability of various forms of parathyroid hormone (PTH) has led to several studies of investigational drugs for this condition.2
Studies from the NICHD and other research centers have shown the investigational drugs PTH 1-34 or PTH 1-84 injections work well as an alternative to conventional therapy. Research shows that PTH 1-34 given as an injection twice daily or through a pump (originally designed for diabetics) is an effective way to treat most forms of congenital hypoparathyroidism.3,4,5
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