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Featured Articles

The following featured articles include those from NICHD researchers or NICHD-supported researchers.

  • Introini, A., Vanpouille, C., Lisco, A., Grivel, J.C., & Margolis, L. (2013). Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo. PLoS Pathogens, 9(2), e1003148. PMID: 23408885
  • Kreitchmann, R., Best, B. M., Wang, J., Stek, A., Caparelli, E., Watts, D. H., et al. (2013). Pharmacokinetics of an i ncreased atazanavir dose with and without tenofovir during the third trimester of pregnancy. Journal of Acquired Immune Deficiency Syndromes, 63(1), 59–66. PMID: 23392467
  • Margolis, L. (2013). It takes more than two for this tango. Cell Host Microbe, 13(1), 1– 3. PMID:23332149
  • Saba, E., Origoni, M., Taccagni, G., Ferrari, D., Doglioni, C., Nava, A., et al. (2013). Productive HIV-1 infection of human cervical tissue ex vivo is associated with the secretory phase of the menstrual cycle. Mucosal Immunology, doi: 10.1038/mi.2013.2. PMID:23385427
  • Lisco, A., Introini, A., Munawwar, A., Vanpouille, C., Grivel, J.C., Blank, P., et al. (2012). HIV-1 imposes rigidity on blood and semen cytokine networks. American Journal of Reproductive Immunology, 68(6), 515–5 21. PMID: 23006048
  • Merbah, M., Arakelyan, A., Edmonds, T., Ochsenbauer, C., Kappes, J. C., Shattock, R. J., et al. (2012). HIV-1 expressing the envelopes of transmitted/founder or control/reference viruses have similar infection patterns of CD4 T-cells in human cervical tissue ex vivo. PLoS One, 7(12), e50839. PMID: 23236398
  • Read, J. S ., Cohen, R. A., Hance, L. F., Machado, E. S., Mussi-Pinhata, M. M., Ceriotto, M., et al. (2012). Missed opportunities for prevention of mother-to-child transmission of HIV-1 in the NISDI Perinatal and LILAC cohorts. International Journal of Gynaecology and Obstetrics, 119(1), 70 –75. PMID: 22819316
  • Vanpouille, C., Arakelyan, A., & Margolis, L. (2012). Microbicides: still a long road to success. Trends in Microbiology, 20(8), 369–3 75. PMID: 22705107
  • Davies, M. A., Moultrie, H., Eley, B., Rabie, H., Van Cutsem, G., Giddy, J., et al., International Epidemiologic Databases to Evaluate AIDS Southern Africa (IeDEA-SA) Collaboration. (2011). Virologic failure and second-line antiretroviral therapy in children in South Africa-the IeDEA Southern Africa collaboration. Journal of Acquired Immune Deficiency Syndromes, 56(3), 270– 278. PMID: 21107266

Here is a selection of recent papers, listed by the following themes:
Pediatric Treatment
Complications of HIV or Treatment in Children
HIV in Children
Antiretroviral Drugs in Pregnancy
Prevention of Mother-to-Child HIV Transmission
Adolescents
HIV and Women
Co-Infections

Pediatric Treatment

  • Palumbo, P., Lindsey, J. C., Hughes, M. D., Cotton, M. F., Bobat, R., Meyers, T., et al. (2010). Antiretroviral treatment for children with peripartum nevirapine exposure. N Engl J Med. Oct 14;363(16):1510-20. PMID: 20942667
  • Babiker, A., Castro, nee Green, H., Compagnucci, A., Fiscus, S., Giaquinto, C., Gibb, D. M., et al. (2011). First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: an open-label, randomised phase 2/3 trial. Lancet Infect Dis. Apr;11(4):273-83. PMID: 21288774
  • Kuhn, L., Coovadia, A., Strehlau, R., Martens, L., Hu, C. C., Meyers, T., et al. (2012). Switching children previously exposed to nevirapine to nevirapine-based treatment after initial suppression with a protease-inhibitor-based regimen: long-term follow-up of a randomised, open-label trial. Lancet Infect Dis. Mar 15. [Epub ahead of print] PMID: 22424722
  • Violari, A., Lindsey, J. C., Hughes, M. D., Mujuru, H. A., Barlow-Mosha, L., Kamthunzi, P., et al. (2012). Nevirapine verus ritonavir-boosted lopinavir for HIV-infected children. New England Journal of Medicine, 366(25), 2380–238 9. PMID 22716976
  • Puthanakit, T., Saphonn, V., Ananworanich, J., Kosalaraksa, P., Hansudewechakul, R., Vibol, U., et al.; PREDICT Study Group. (2012). Early versus deferred antiretroviral therapy for children older than 1 year infected with HIV (PREDICT): a multicentre, randomised, open-label trial. Lancet Infectious Diseases,12(12), 933–9 41. PMID: 23059199
  • Coovadia, A., Abrams, E. J., Stehlau, R., Meyers, T., Martens, L., Sherman, G., et al. (2010). Reuse of nevirapine in exposed HIV-infected children after protease inhibitor-based viral suppression: a randomized controlled trial. JAMA, 304(10), 1082 –1090. PMID: 20823434

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Complications of HIV or Treatment in Children

  • Hazra, R., Cohen, R. A., Gonin, R., Monteiro, J. P., Hofer, C. B., Negra, M. D., et al. (2012). Lipid levels in the second year of life among HIV-infected and HIV-exposed uninfected Latin American children. AIDS. Jan 14;26(2):235-40. PMID: 22008654
  • Purswani, M., Patel, K., Kopp, J. B., Seage, G. R. 3rd, Chernoff, M. C., Hazra, R., et al.; for the Pediatric HIVAIDS Cohort Study. (2012). Tenofovir treatment duration predicts proteinuria in a multi-ethnic United States cohort of children and adolescents with perinatal HIV-1 infection. Pediatric Infectious Disease Journal, [Epub ahead of print] PMID: 23249917
  • Torre, P. 3rd, Zeldow, B., Hoffman, H. J., Buchanan, A., Siberry, G. K., Rice, M., et al.; Pediatric HIVAIDS Cohort Study. (2012). Hearing loss in perinatally HIV-infected and HIV-exposed but uninfected children and adolescents. Pediatric Infectious Disease Journal, 31(8), 835 –841. PMID: 22549437
  • Miller, T., Borkowsky, W., Dimeglio, L., Dooley, L., Geffner, M., Hazra, R., et al. (2012). Metabolic abnormalities and viral replication are associated with biomarkers of vascular dysfunction in HIV-infected children. HIV Medicine,13(5), 264– 275. PMID: 22136114
  • Lipshultz, S. E., Williams, P. L., Wilkinson, J. D., Leister, E. C., Van Dyke, R. B., Shearer, W. T., et al.; for the Pediatric HIV/AIDS Cohort Study (PHACS). (2013). Cardiac status of children infected with human immunodeficiency virus who are receiving long-term combination antiretroviral therapy: results from the Adolescent Master Protocol of the Multicenter Pediatric HIV/AIDS Cohort Study. JAMA Pediatrics, 167(6), 520 –527. PMID: 23608879
  • Wilkinson, J. D., Williams, P. L., Leister, E., Zeldow, B., Shearer, W. T., Colan, S. D., et al.; for the Pediatric HIVAIDS Cohort Study (PHACS). (2012). Cardiac biomarkers in HIV-exposed uninfected children: The Pediatric HIV/AIDS Cohort Study (PHACS). AIDS, 2012 Dec 3. [Epub ahead of print] PMID: 2321177

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HIV in Children

  • Puthanakit, T., Ananworanich, J., Vonthanak, S., Kosalaraksa, P., Hansudewechakul, R., van der Lugt, J., et al. (2013). Cognitive function and neurodevelopmental outcomes in HIV-infected children older than 1 year of age randomized to early versus deferred antiretroviral therapy: The PREDICT Neurodevelopmental Study. Pediatric Infectious Diseases Journal, 2013 Jan 2. [Epub ahead of print] PMID: 23263176
  • Leroy, V., Malateste, K., Rabie, H., Lumbiganon, P., Ayaya, S., Dicko, F., et al.; International IeDEA Pediatric Working Group. (2013). Outcomes of antiretroviral therapy in children in Asia and Africa: a comparative analysis of the IeDEA pediatric multiregional collaboration. Journal of Acquired Immune Deficiency Syndromes, 62(2), 208–219. PMID: 23187940
  • Siberry, G. K., Harris, D. R., Oliveira, R. H., Krauss, M. R., Hofer, C. B., Tiraboschi, A. A., et al. (2012). Evaluation of viral load thresholds for predicting new WHO Stage 3 and 4 events in HIV-infected children receiving highly active antiretroviral therapy. J Acquir Immune Defic Syndr. Feb 16. [Epub ahead of print] PMID: 22343177
  • Ruel, T. D., Boivin, M. J., Boal, H. E., Bangirana, P., Charlebois, E., Havlir, D. V., et al. (2012). Neurocognitive and Motor Deficits in HIV-Infected Ugandan Children With High CD4 Cell Counts. Clin Infect Dis. Apr;54(7):1001-9. PMID: 22308272
  • Davies, M. A., Boulle, A., Eley, B., Moultrie, H., Technau, K., Rabie, H., et al. (2011). Accuracy of immunological criteria for identifying virological failure in children on antiretroviral therapy - The IeDEA Southern Africa Collaboration. Trop Med Int Health. 2011 Aug 11. doi: 10.1111/j.1365-3156.2011.02854.x. PMID: 21834797

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Antiretroviral Drugs in Pregnancy

  • Watts, D. H., Williams, P. L., Kacanek, D., Griner, R., Rich, K., Hazra, R., et al.; Pediatric HIV/AIDS Cohort Study. (2013). Combination antiretroviral use and preterm birth. Journal of Infectious Diseases, 207(4), 612–621. PMID: 23204173
  • Siberry, G. K., Williams, P. L., Mendez, H., Seage, G. R. 3rd, Jacobson, D. L., Hazra, R., et al. (2012). Safety of tenofovir use during pregnancy: early growth outcomes in HIV-exposed uninfected infants. AIDS. 2012 Feb 29. [Epub ahead of print] PMID: 22382151
  • Watts, D. H., & Mofenson, L. M. (2012). Antiretrovirals in pregnancy: a note of caution. Journal of Infectious Diseases, 206(11), 1639–1641. PMID: 23066163
  • Ford, N., Calmy, A., & Mofenson, L. (2011). Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis. AIDS. Nov 28;25(18):2301-4. PMID: 21918421
  • Rice, M. L., Buchanan, A.L., Siberry, G. K., Malee, K. M., Zeldow, B., Frederick, T., et al. (2012). Language impairment in children perinatally infected with HIV compared to children who were HIV-exposed and uninfected. J Dev Behav Pediatr. Feb;33(2):112-23. PMID: 22179050

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Prevention of Mother-to-Child HIV Transmission

  • Fogel, J. M., Mwatha, A., Richardson, P., Brown, E. R., Chipato, T., Alexandre, M., et al. (2013). Impact of maternal and infant antiretroviral drug regimens on drug resistance in HIV-infected breastfeeding infants. Pediatric Infectious Disease Journal, 32(4), e164–e169. PMID: 23249916
  • Nielsen-Saines, K., Watts, D. H., Veloso, V. G., Bryson, Y. J., Joao, E. C., Pilotto, J. H., et al.; NICHD HPTN 040/PACTG 1043 Protocol Team. (2012). Three postpartum antiretroviral regimens to prevent intrapartum HIV infection. New England Journal of Medicine, 366(25), 2368–2379. PMID: 22716975
  • Coovadia, H. M., Brown, E. R., Fowler, M. G., Chipato, T., Moodley, D., Manji, K., et al. (2012). Efficacy and safety of an extended nevirapine regimen in infant children of breastfeeding mothers with HIV-1 infection for prevention of postnatal HIV-1 transmission (HPTN 046): a randomised, double-blind, placebo-controlled trial. Lancet. Jan 21;379(9812):221-8. PMID: 22196945
  • Nachega, J. B., Uthman, O. A., Anderson, J., Peltzer, K., Wampold, S., Cotton, M. F., et al. (2012). Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis. AIDS, 26(16), 2039–2052. PMID: 2951634

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Adolescents

  • Tassiopoulos, K., Moscicki, A. B., Mellins, C., Kacanek, D., Malee, K., Allison, S., et al.; Pediatric HIV/AIDS Cohort Study. (2013). Sexual risk behavior among youth with perinatal HIV infection in the United States: predictors and implications for intervention development. Clinical Infectious Diseases, 56(2), 283–290. PMID: 23139252
  • Havens, P. L., Stephensen, C. B., Hazra, R., Flynn, P. M., Wilson, C. M., Rutledge, B., et al. (2012). Vitamin D3 Decreases Parathyroid Hormone in HIV-Infected Youth Being Treated With Tenofovir: A Randomized, Placebo-Controlled Trial. Clin Infect Dis. Apr;54(7):1013-1025. PMID: 22267714
  • Kapogiannis, B. G., Handelsman, E., Ruiz, M. S., & Lee, S. J. (2010). Paving the way for biomedical HIV prevention interventions in youth. Acquir Immune Defic Syndr. Jul;54 Suppl 1:S1-4. PMID: 20571417
  • Arrivé, E., Dicko, F., Amghar, H., Aka, A. E., Dior, H., Bouah, B., et al. (2012). HIV Status Disclosure and Retention in Care in HIV-Infected Adolescents on Antiretroviral Therapy (ART) in West Africa. PLoS One. 7(3):e33690. Epub 2012 Mar 21. PMID: 22457782

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HIV and Women

  • Massad, L. S., Xie, X., Greenblatt, R. M., Minkoff, H., Sanchez-Keeland, L., Watts, D. H., et al. (2012). Effect of human immunodeficiency virus infection on the prevalence and incidence of vaginal intraepithelial neoplasia. Obstet Gynecol. Mar;119(3):582-9. PMID: 22353957
  • Beigi, R., Noguchi, L., Parsons, T., Macio, I., Kunjara Na Ayudhya, R. P., Chen, J., et al. (2011). Pharmacokinetics and placental transfer of single-dose tenofovir 1% vaginal gel in term pregnancy. J Infect Dis. Nov 15;204(10):1527-31. PMID: 21930612
  • Bambha, K., Pierce, C., Cox, C., French, A. L., Tien, P. C., Sharp, G. B., et al. (2012). Assessing mortality in women with hepatitis C virus and HIV using indirect markers of fibrosis. AIDS, 26(5), 599– 607. PMID: 22156972
  • Gandhi, M., Ameli, N., Bacchetti, P., Anastos, K., Gange, S. J., Minkoff, H., et al. (2011). Atazanavir concentration in hair is the strongest predictor of outcomes on antiretroviral therapy. Clin Infect Dis. May;52(10):1267-75. PMID: 21507924

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Co-Infections

  • Nicol, M. P., Spiers, K., Workman, L., Isaacs, W., Munro, J., Black, F., et al. (2013). Xpert MTB/RIF testing of stool samples for the diagnosis of pulmonary tuberculosis in children. Clinical Infectious Diseases, [Epub ahead of print]. PMID: 23580738
  • Achan, J., Kakuru, A., Ikilezi, G., Ruel, T., Clark, T. D., Nsanzabana, C., et al. (2012). Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children. New England Journal of Medicine, 367(22), 2110–2118. PMID: 23190222
  • Zar, H. J., Workman, L., Isaacs, W., Munro, J., Black, F., Eley, B., et al. (2012). Rapid molecular diagnosis of pulmonary tuberculosis in children using nasopharyngeal specimens. Clinical Infectious Diseases, 55(8), 1088–1095. PMID: 22752518
  • Nicol, M. P., Workman, L., Isaacs, W., Munro, J., Black, F., Eley, B., et al. (2011)..Accuracy of the Xpert MTB/RIF test for the diagnosis of pulmonary tuberculosis in children admitted to hospital in Cape Town, South Africa: a descriptive study. Lancet Infect Dis. Nov;11(11):819-24. PMID: 21764384
  • Graham, S. M., Ahmed, T., Amanullah, F., Browning, R., Cardenas, V., Casenghi, M., et al. (2012). Evaluation of Tuberculosis Diagnostics in Children: 1. Proposed Clinical Case Definitions for Classification of Intrathoracic Tuberculosis Disease. Consensus From an Expert Panel. J Infect Dis. Mar 23. [Epub ahead of print] PMID: 22448023
  • Cuevas, L. E., Browning, R., Bossuyt, P., Casenghi, M., Cotton, M. F., Cruz, A. T., et al. (2012). Evaluation of Tuberculosis Diagnostics in Children: 2. Methodological Issues for Conducting and Reporting Research Evaluations of Tuberculosis Diagnostics for Intrathoracic Tuberculosis in Children. Consensus From an Expert Panel. J Infect Dis. Apr 3. [Epub ahead of print] PMID: 22476719
  • Goodreau SM, Cassels S, Kasprzyk D, Montaño DE, Greek A, & Morris M. (2012) Concurrent partnerships, acute infection and HIV epidemic dynamics among young adults in Zimbabwe. AIDS Behav. Feb;16(2):312-22. PMID: 21190074
  • Trinitapoli, J., & Yeatman, S. (2011). Uncertainty and fertility in a generalized AIDS epidemic. American Sociological Review. 76(6) 935–954.
  • Bärnighausen T, Tanser F, Dabis F, Newell ML. (2012). Interventions to improve the performance of HIV health systems for treatment-as-prevention in sub-Saharan Africa: the experimental evidence. Curr Opin HIV AIDS. Mar;7(2):140-50. PMID: 22248917

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Last Updated Date: 12/16/2013
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