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How many people are affected by or at risk for FXPOI?

Although the exact number of people with an FMR1 premutation is not known, estimates suggest that about 1 in 259 women may have the premutation.1 But only about 20% to 25% of women with a premutation will develop FXPOI.2


  1. Hersh, J. H., Saul R. A., & Committee on Genetics. (2011). Health supervision for children with fragile X syndrome. Pediatrics, 127, 994-1006. [top]
  2. National Fragile X Foundation. (2011). Prevalence of FXTAS. Retrieved September 10, 2012, from http://www.fxtas.org/prevalence.htm [top]

Last Updated Date: 11/30/2012
Last Reviewed Date: 11/30/2012
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Epidemiology Statistics and Prevention Branch Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology