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Han, JOAN

Formal Title:

 

Responsibilities:

Pediatric endocrinology patient care, teaching of trainees in the fellowship program, and research on the neuroendocrine regulation of energy balance and neurocognitive function

Phone:

301-435-7820

Email:

joan.han@nih.gov

Address:

10 CENTER DR Room 1-3232
Bethesda Md 20892
For FedEx use:
Bethesda Md 20892

Biosketch:

Dr. Han received an A.B. from Harvard College and an M.D. from Harvard Medical School.  She completed residency in the Boston Combined Residency Program in Pediatrics at Children’s Hospital Boston and Boston Medical Center.  She received clinical research training at Nemours Children’s Clinic in Jacksonville, Florida, and completed pediatric endocrinology fellowship at the National Institutes of Health.  Since December 2009, she has been an Assistant Clinical Investigator and Head of the Unit on Metabolism and Neuroendocrinology in the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. 

Her translational research aims to gain insight into the neuroendocrine regulation of human energy balance and neurocognitive function.  Clinical studies focus on patients with genetic disorders (e.g. MC4R mutation, Alstrom, Bardet-Biedl, Prader-Willi, Smith-Magenis, and WAGR/11p deletion syndromes) that are associated with childhood obesity and who frequently also display intellectual, psychiatric, and behavioral abnormalities. Candidate genes identified from these studies are further investigated in non-syndromic populations to determine if common genetic variants are associated with differences in body composition and neurocognition. The focus of laboratory investigations is elucidation of the mechanisms by which these genetic variants alter metabolism and neurodevelopment, with the goal of identifying deficit-specific therapies for obesity and neurocognitive impairment.

 

Publications (PubMed):

 
Title Authors Publication Date
Amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) predicts height velocity in healthy children.Olney RC,Permuy JW,Prickett TC,Han JC,Espiner EAClin Endocrinol (Oxf)2012 Sep
Patients with Bardet-Biedl syndrome have hyperleptinemia suggestive of leptin resistance.Feuillan PP,Ng D,Han JC,Sapp JC,Wetsch K,Spaulding E,Zheng YC,Caruso RC,Brooks BP,Johnston JJ,Yanovski JA,Biesecker LGJ Clin Endocrinol Metab2011 Mar
Effects of growth hormone and nutritional therapy in boys with constitutional growth delay: a randomized controlled trial.Han JC,Damaso L,Welch S,Balagopal P,Hossain J,Mauras NJ Pediatr2011 Mar
Childhood obesity.Han JC,Lawlor DA,Kimm SYLancet2010 May 15
Lower brain-derived neurotrophic factor in patients with prader-willi syndrome compared to obese and lean control subjects.Han JC,Muehlbauer MJ,Cui HN,Newgard CB,Haqq AMJ Clin Endocrinol Metab2010 Jul
Investigation of a patient with a partial trisomy 16q including the fat mass and obesity associated gene (FTO): fine mapping and FTO gene expression study.van den Berg L,de Waal HD,Han JC,Ylstra B,Eijk P,Nesterova M,Heutink P,Stratakis CAAm J Med Genet A2010 Mar
Psychological symptoms and insulin sensitivity in adolescents.Shomaker LB,Tanofsky-Kraff M,Young-Hyman D,Han JC,Yanoff LB,Brady SM,Yanovski SZ,Yanovski JAPediatr Diabetes2010 Sep
Compound heterozygosity for mutations in PAX6 in a patient with complex brain anomaly, neonatal diabetes mellitus, and microophthalmia.Solomon BD,Pineda-Alvarez DE,Balog JZ,Hadley D,Gropman AL,Nandagopal R,Han JC,Hahn JS,Blain D,Brooks B,Muenke MAm J Med Genet A2009 Nov
The stability of metabolic syndrome in children and adolescents.Gustafson JK,Yanoff LB,Easter BD,Brady SM,Keil MF,Roberts MD,Sebring NG,Han JC,Yanovski SZ,Hubbard VS,Yanovski JAJ Clin Endocrinol Metab2009 Dec
The FTO gene rs9939609 obesity-risk allele and loss of control over eating.Tanofsky-Kraff M,Han JC,Anandalingam K,Shomaker LB,Columbo KM,Wolkoff LE,Kozlosky M,Elliott C,Ranzenhofer LM,Roza CA,Yanovski SZ,Yanovski JAAm J Clin Nutr2009 Dec
Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor.Savastano DM,Tanofsky-Kraff M,Han JC,Ning C,Sorg RA,Roza CA,Wolkoff LE,Anandalingam K,Jefferson-George KS,Figueroa RE,Sanford EL,Brady S,Kozlosky M,Schoeller DA,Yanovski JAAm J Clin Nutr2009 Oct
Brain-derived neurotrophic factor and obesity in the WAGR syndrome.Han JC,Liu QR,Jones M,Levinn RL,Menzie CM,Jefferson-George KS,Adler-Wailes DC,Sanford EL,Lacbawan FL,Uhl GR,Rennert OM,Yanovski JAN Engl J Med2008 Aug 28
Insulin resistance, hyperinsulinemia, and energy intake in overweight children.Han JC,Rutledge MS,Kozlosky M,Salaita CG,Gustafson JK,Keil MF,Fleisch AF,Roberts MD,Ning C,Yanovski JAJ Pediatr2008 May
Oxygen-uptake efficiency slope as a determinant of fitness in overweight adolescents.Drinkard B,Roberts MD,Ranzenhofer LM,Han JC,Yanoff LB,Merke DP,Savastano DM,Brady S,Yanovski JAMed Sci Sports Exerc2007 Oct
Amino-terminal propeptide of C-type natriuretic peptide and linear growth in children: effects of puberty, testosterone, and growth hormone.Olney RC,Prickett TC,Yandle TG,Espiner EA,Han JC,Mauras NJ Clin Endocrinol Metab2007 Nov
Influence of serum leptin on weight and body fat growth in children at high risk for adult obesity.Fleisch AF,Agarwal N,Roberts MD,Han JC,Theim KR,Vexler A,Troendle J,Yanovski SZ,Yanovski JAJ Clin Endocrinol Metab2007 Mar
Evidence for hypermetabolism in boys with constitutional delay of growth and maturation.Han JC,Balagopal P,Sweeten S,Darmaun D,Mauras NJ Clin Endocrinol Metab2006 Jun
Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene.Gray J,Yeo GS,Cox JJ,Morton J,Adlam AL,Keogh JM,Yanovski JA,El Gharbawy A,Han JC,Tung YC,Hodges JR,Raymond FL,O'rahilly S,Farooqi ISDiabetes2006 Dec
Association of brain-derived neurotrophic factor (BDNF) haploinsufficiency with lower adaptive behaviour and reduced cognitive functioning in WAGR/11p13 deletion syndrome.Han JC,Thurm A,Golden Williams C,Joseph LA,Zein WM,Brooks BP,Butman JA,Brady SM,Fuhr SR,Hicks MD,Huey AE,Hanish AE,Danley KM,Raygada MJ,Rennert OM,Martinowich K,Sharp SJ,Tsao JW,Swedo SECortex2013 Nov-Dec
Whole-exome sequencing identifies novel LEPR mutations in individuals with severe early onset obesity.Gill R,Cheung YH,Shen Y,Lanzano P,Mirza NM,Ten S,Maclaren NK,Motaghedi R,Han JC,Yanovski JA,Leibel RL,Chung WKObesity (Silver Spring)2014 Feb
Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia.Heymsfield SB,Avena NM,Baier L,Brantley P,Bray GA,Burnett LC,Butler MG,Driscoll DJ,Egli D,Elmquist J,Forster JL,Goldstone AP,Gourash LM,Greenway FL,Han JC,Kane JG,Leibel RL,Loos RJ,Scheimann AO,Roth CL,Seeley RJ,Sheffield V,Tauber M,Vaisse C,Wang L,Waterland RA,Wevrick R,Yanovski JA,Zinn ARObesity (Silver Spring)2014 Feb
Hyperphagia among patients with Bardet-Biedl syndrome.Sherafat-Kazemzadeh R,Ivey L,Kahn SR,Sapp JC,Hicks MD,Kim RC,Krause AJ,Shomaker LB,Biesecker LG,Han JC,Yanovski JAPediatr Obes2013 Oct
Rapid and inexpensive screening of genomic copy number variations using a novel quantitative fluorescent PCR method.Stofanko M,Han JC,Elsea SH,Pena HB,Gonçalves-Dornelas H,Pena SDDis Markers2013
Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes.Drgonova J,Jacobsson JA,Han JC,Yanovski JA,Fredriksson R,Marcus C,Schiöth HB,Uhl GRPLoS One2013
Brain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants.Hohenadel MG,Thearle MS,Grice BA,Huang H,Dai MH,Tao YX,Hunter LA,Palaguachi GI,Mou Z,Kim RC,Tsang MM,Haack K,Voruganti VS,Cole SA,Butte NF,Comuzzie AG,Muller YL,Baier LJ,Krakoff J,Knowler WC,Yanovski JA,Han JCInt J Obes (Lond)2013 Nov 26

Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology