Hoffman, Dax A
Formal Title:
Investigator
Address:
35 Convent Dr Room 3C905, MSC 3715
Bethesda Md 20892-3715
For FedEx use:
Bethesda Md 20892
Topics in my portfolio:
Neuroscience
Learning Disabilities
Autism Spectrum Disorders (ASDs)
Fragile X Syndrome
Rett Syndrome
Biosketch:
Dr. Hoffman received his B.S. in Genetics from the University of Minnesota in 1994 and his Ph.D. from Baylor College of Medicine 1999, where he studied dendritic K+ channels with Dr. Dan Johnston. During a postdoctoral fellowship with Bert Sakmann at the Max Planck Institute for Medical Research in Heidelberg Germany, he investigated synaptic plasticity and Ca2+ signaling in transgenic and gene-targeted mice. Dr. Hoffman became head of the Molecular Neurophysiology and Biophysics Unit, NICHD in 2002. His laboratory explores dendritic signal processing in CA1 pyramidal neurons of the hippocampus.
Publications (PubMed):
| Title |
Authors |
Publication |
Date |
| Loss of Signal Transducer and Activator of Transcription 3 (STAT3) Signaling during Elevated Activity Causes Vulnerability in Hippocampal Neurons. | Murase S,Kim E,Lin L,Hoffman DA,McKay RD | J Neurosci | 2012 Oct 31 |
| Dynamic Regulation of Synaptic Maturation State by Voltage-Gated A-Type K+ Channels in CA1 Hippocampal Pyramidal Neurons. | Kim E,Hoffman DA | J Neurosci | 2012 Oct 10 |
| Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors. | Kiselycznyk C,Hoffman DA,Holmes A | Biol Mood Anxiety Disord | 2012 Mar 2 |
| A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension. | Charmandari E,Sertedaki A,Kino T,Merakou C,Hoffman DA,Hatch MM,Hurt DE,Lin L,Xekouki P,Stratakis CA,Chrousos GP | J Clin Endocrinol Metab | 2012 Aug |
| Aberrant dendritic excitability: a common pathophysiology in CNS disorders affecting memory? | Nestor MW,Hoffman DA | Mol Neurobiol | 2012 Jun |
| KCNJ5 mutations in the National Institutes of Health cohort of patients with primary hyperaldosteronism: an infrequent genetic cause of Conn's syndrome. | Xekouki P,Hatch MM,Lin L,Rodrigo de A,Azevedo M,de la Luz Sierra M,Levy I,Saloustros E,Moraitis A,Horvath A,Kebebew E,Hoffman DA,Stratakis CA | Endocr Relat Cancer | 2012 Jun |
| DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons. | Sun W,Maffie JK,Lin L,Petralia RS,Rudy B,Hoffman DA | Neuron | 2011 Sep 22 |
| A kinase anchor protein 150 (AKAP150)-associated protein kinase A limits dendritic spine density. | Lu Y,Zha XM,Kim EY,Schachtele S,Dailey ME,Hall DD,Strack S,Green SH,Hoffman DA,Hell JW | J Biol Chem | 2011 Jul 29 |
| Differential cycling rates of Kv4.2 channels in proximal and distal dendrites of hippocampal CA1 pyramidal neurons. | Nestor MW,Hoffman DA | Hippocampus | 2012 May |
| AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking. | Lin L,Sun W,Kung F,Dell'Acqua ML,Hoffman DA | J Neurosci | 2011 Jan 26 |
| Kv4.2 block of long-term potentiation is partially dependent on synaptic NMDA receptor remodeling. | Jung SC,Eun SY,Kim J,Hoffman DA | Brain Res Bull | 2011 Jan 15 |
| Dendritic ion channel trafficking and plasticity. | Shah MM,Hammond RS,Hoffman DA | Trends Neurosci | 2010 Jul |
| KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation. | Lin L,Sun W,Wikenheiser AM,Kung F,Hoffman DA | Mol Cell Neurosci | 2010 Mar |
| Biphasic somatic A-type K channel downregulation mediates intrinsic plasticity in hippocampal CA1 pyramidal neurons. | Jung SC,Hoffman DA | PLoS One | 2009 Aug 7 |
| Rapid, bidirectional remodeling of synaptic NMDA receptor subunit composition by A-type K+ channel activity in hippocampal CA1 pyramidal neurons. | Jung SC,Kim J,Hoffman DA | Neuron | 2008 Nov 26 |
| Firing first: compensatory changes in K+ channel knockout mice preserve excitability but not synaptic scaling. | Hoffman D | J Physiol | 2008 Aug 15 |
| Kv4 accessory protein DPPX (DPP6) is a critical regulator of membrane excitability in hippocampal CA1 pyramidal neurons. | Kim J,Nadal MS,Clemens AM,Baron M,Jung SC,Misumi Y,Rudy B,Hoffman DA | J Neurophysiol | 2008 Oct |
| Protein kinase a mediates activity-dependent Kv4.2 channel trafficking. | Hammond RS,Lin L,Sidorov MS,Wikenheiser AM,Hoffman DA | J Neurosci | 2008 Jul 23 |
| Neuregulins and neuronal plasticity: possible relevance in schizophrenia. | Buonanno A,Kwon OB,Yan L,Gonzalez C,Longart M,Hoffman D,Vullhorst D | Novartis Found Symp | 2008 |
| Potassium channels: newly found players in synaptic plasticity. | Kim J,Hoffman DA | Neuroscientist | 2008 Jun |
| Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neurons. | Kim J,Jung SC,Clemens AM,Petralia RS,Hoffman DA | Neuron | 2007 Jun 21 |
| Neuregulin-1 reverses long-term potentiation at CA1 hippocampal synapses. | Kwon OB,Longart M,Vullhorst D,Hoffman DA,Buonanno A | J Neurosci | 2005 Oct 12 |
| Kv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neurones. | Kim J,Wei DS,Hoffman DA | J Physiol | 2005 Nov 15 |
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