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Hoffman, Dax A

Formal Title:

Investigator

Phone:

301-402-6772

Email:

dh347r@nih.gov

Address:

35 CONVENT DR Room 3C905, MSC 3715
Bethesda Md 20892-3715
For FedEx use:
Bethesda Md 20892

Biosketch:

Dr. Hoffman received his B.S. in Genetics from the University of Minnesota in 1994 and his Ph.D. from Baylor College of Medicine 1999, where he studied dendritic K+ channels with Dr. Dan Johnston. During a postdoctoral fellowship with Bert Sakmann at the Max Planck Institute for Medical Research in Heidelberg Germany, he investigated synaptic plasticity and Ca2+ signaling in transgenic and gene-targeted mice. Dr. Hoffman became head of the Molecular Neurophysiology and Biophysics Unit, NICHD in 2002. His laboratory explores dendritic signal processing in CA1 pyramidal neurons of the hippocampus.

Publications (PubMed):

 
Title Authors Publication Date
Loss of Signal Transducer and Activator of Transcription 3 (STAT3) Signaling during Elevated Activity Causes Vulnerability in Hippocampal Neurons.Murase S,Kim E,Lin L,Hoffman DA,McKay RDJ Neurosci2012 Oct 31
Dynamic Regulation of Synaptic Maturation State by Voltage-Gated A-Type K+ Channels in CA1 Hippocampal Pyramidal Neurons.Kim E,Hoffman DAJ Neurosci2012 Oct 10
Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors.Kiselycznyk C,Hoffman DA,Holmes ABiol Mood Anxiety Disord2012 Mar 2
A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension.Charmandari E,Sertedaki A,Kino T,Merakou C,Hoffman DA,Hatch MM,Hurt DE,Lin L,Xekouki P,Stratakis CA,Chrousos GPJ Clin Endocrinol Metab2012 Aug
Aberrant dendritic excitability: a common pathophysiology in CNS disorders affecting memory?Nestor MW,Hoffman DAMol Neurobiol2012 Jun
KCNJ5 mutations in the National Institutes of Health cohort of patients with primary hyperaldosteronism: an infrequent genetic cause of Conn's syndrome.Xekouki P,Hatch MM,Lin L,Rodrigo de A,Azevedo M,de la Luz Sierra M,Levy I,Saloustros E,Moraitis A,Horvath A,Kebebew E,Hoffman DA,Stratakis CAEndocr Relat Cancer2012 Jun
DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons.Sun W,Maffie JK,Lin L,Petralia RS,Rudy B,Hoffman DANeuron2011 Sep 22
A kinase anchor protein 150 (AKAP150)-associated protein kinase A limits dendritic spine density.Lu Y,Zha XM,Kim EY,Schachtele S,Dailey ME,Hall DD,Strack S,Green SH,Hoffman DA,Hell JWJ Biol Chem2011 Jul 29
Differential cycling rates of Kv4.2 channels in proximal and distal dendrites of hippocampal CA1 pyramidal neurons.Nestor MW,Hoffman DAHippocampus2012 May
AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking.Lin L,Sun W,Kung F,Dell'Acqua ML,Hoffman DAJ Neurosci2011 Jan 26
Kv4.2 block of long-term potentiation is partially dependent on synaptic NMDA receptor remodeling.Jung SC,Eun SY,Kim J,Hoffman DABrain Res Bull2011 Jan 15
Dendritic ion channel trafficking and plasticity.Shah MM,Hammond RS,Hoffman DATrends Neurosci2010 Jul
KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.Lin L,Sun W,Wikenheiser AM,Kung F,Hoffman DAMol Cell Neurosci2010 Mar
Biphasic somatic A-type K channel downregulation mediates intrinsic plasticity in hippocampal CA1 pyramidal neurons.Jung SC,Hoffman DAPLoS One2009 Aug 7
Rapid, bidirectional remodeling of synaptic NMDA receptor subunit composition by A-type K+ channel activity in hippocampal CA1 pyramidal neurons.Jung SC,Kim J,Hoffman DANeuron2008 Nov 26
Firing first: compensatory changes in K+ channel knockout mice preserve excitability but not synaptic scaling.Hoffman DJ Physiol2008 Aug 15
Kv4 accessory protein DPPX (DPP6) is a critical regulator of membrane excitability in hippocampal CA1 pyramidal neurons.Kim J,Nadal MS,Clemens AM,Baron M,Jung SC,Misumi Y,Rudy B,Hoffman DAJ Neurophysiol2008 Oct
Protein kinase a mediates activity-dependent Kv4.2 channel trafficking.Hammond RS,Lin L,Sidorov MS,Wikenheiser AM,Hoffman DAJ Neurosci2008 Jul 23
Neuregulins and neuronal plasticity: possible relevance in schizophrenia.Buonanno A,Kwon OB,Yan L,Gonzalez C,Longart M,Hoffman D,Vullhorst DNovartis Found Symp2008
Potassium channels: newly found players in synaptic plasticity.Kim J,Hoffman DANeuroscientist2008 Jun
Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neurons.Kim J,Jung SC,Clemens AM,Petralia RS,Hoffman DANeuron2007 Jun 21
Neuregulin-1 reverses long-term potentiation at CA1 hippocampal synapses.Kwon OB,Longart M,Vullhorst D,Hoffman DA,Buonanno AJ Neurosci2005 Oct 12
Kv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neurones.Kim J,Wei DS,Hoffman DAJ Physiol2005 Nov 15

Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology