Skip Navigation
  Print Page

Macfarlan Lab: Unit on Mammalian Epigenome Reprogramming

Skip sharing on social media links
Share this:
Skip Internal Navigation ​​​​

Training and Education Opportunities

Postdoc: Molecular Biology/Biochemistry/Genetics/Developmental Biology

Two postdoc positions available July 1 to study mechanisms of epigenome reprogramming in mammals at the National Institutes of Health, Bethesda, MD. The Section on Mammalian Epigenome Reprogramming headed by Todd Macfarlan was established under the Earl Stadtman investigator program, designed to facilitate high risk-high impact science (http://irp.nih.gov/careers/careers-in-action/science-the-stadtman-way). The laboratory uses a multi-disciplinary approach combining molecular, biochemical, genetic, and cellular techniques to understand how epigenomes are modified during mouse development, with particular emphasis on the pre-implantation period and during development of the central nervous system. Current projects include exploring the context-dependent function of histone modifying enzymes during development and during differentiation of stem cells, studying the interplay of transcription factors and chromatin modifying enzymes during artificial reprogramming, and exploring the impact of endogenous retroviruses and their remnants on host genomes. Candidates will have access to multi-dimensional imaging core facilities, substantial mouse colony space, ample support for next generation sequencing applications (ChIP-Seq, RNA-Seq, etc.), and outstanding stipend support.

Requirements:

Interested candidates must have a Ph.D. or M.D. within the past five years in molecular biology, biochemistry, genetics, or a related field. Experience with mouse genetics, mouse development, ES/iPS cell culture, and/or next generation sequencing approaches is a plus.

To apply:

Send a coverletter with desired start date, a CV with bibliography, a brief description of research experience and interests, and the names of 3 references with contact information (including phone numbers) to todd.macfarlan@nih.gov.

Postdoc: Computational Scientist

A bioinformatics postdoctoral position is available July 1 to study mechanisms of epigenome reprogramming in mammals at the National Institutes of Health, Bethesda, MD. The Section on Mammalian Epigenome Reprogramming headed by Todd Macfarlan was established under the Earl Stadtman investigator program, designed to facilitate high risk-high impact science (http://irp.nih.gov/careers/careers-in-action/science-the-stadtman-way). The laboratory uses a multi-disciplinary approach combining molecular, biochemical, genetic, and cellular techniques to understand how epigenomes are modified during mouse development, with particular emphasis on the pre-implantation period and during development of the central nervous system. Current projects include exploring the context-dependent function of histone modifying enzymes during development and during differentiation of stem cells, studying the interplay of transcription factors and chromatin modifying enzymes during artificial reprogramming, and exploring the impact of endogenous retroviruses on host genomes.

The candidate will work closely with experimental biologists to study mechanisms of epigenome reprogramming, and will be expected to utilize available tools and develop new tools for comparative genomics analysis and analysis of next generation sequencing data (including ChIP-Seq, mRNA-Seq, miRNA-Seq, etc.) Opportunities for extensive collaboration with the NIH community are available.

Requirements:

The ideal candidate will have a Ph.D. in Computer Science, Biostatistics or Bioinformatics within the past five years. Programming skills with R, Python, Perl are required. Familiarity with Bowtie, Tophat, Cufflinks, BWA, Samtools, Bedtools, Bamtools, Muscle, MACS, and NCBI blast software is a plus, as is knowledge of on-line resources including UCSC Genome Browser, NCBI, Ensemble, DAVID, genetontology.org and AmiGO.

To apply:

Send a coverletter, a CV with bibliography, a brief description of research experience and interests, and the names of 3 references with contact information (including phone numbers) to todd.macfarlan@nih.gov.

Last Updated Date: 12/06/2012
Last Reviewed Date: 12/06/2012

Contact Information

Name: Dr Todd Scott Macfarlan
Unit on Mammalian Epigenome Reprogramming
Phone: 301-594-9175
Email: macfarlants@mail.nih.gov

Staff Directory
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology