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Loh Lab: Section on Cellular Neurobiology

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Overview

Y. Peng Loh's Section on Cellular Neurobiology explores the mechanisms of intracellular trafficking and secretion of peptide hormones, neuropeptides, and neurotrophins in endocrine cells and neurons as well as the role of the prohormone processing enzyme carboxypeptidase E in stress, neuroprotection, and tumorigenesis. Major accomplishments over the past year include establishing the role of serpinin, a novel secreted chromogranin A–derived peptide, in regulating dense core secretory granule biogenesis through a cAMP-PKA-sp1 pathway, in an autocrine manner, in pituitary corticotrophic cells; elucidation of the mechanism of action of a novel splice isoform of carboxypeptidase E in promoting tumor metastasis; and clinical studies demonstrating that the isoform is a powerful prognostic biomarker for predicting metastasis in hepatocellular carcinoma and pheochromocytoma patients.

Last Updated Date: 11/30/2012
Last Reviewed Date: 11/30/2012

Contact Information

Name: Dr Y Peng Loh
Senior Investigator
Section on Cellular Neurobiology
Phone: 301-496-3239
Fax: 301-496-9938
Email: lohp@mail.nih.gov

Staff Directory
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology