Skip Navigation
  Print Page

Buonanno Lab: Section on Molecular Neurobiology

Skip sharing on social media links
Share this:
Skip Internal Navigation ​​​​

Overview

Andres Buonanno, who heads the Section on Molecular Neurobiology, and his colleagues focus on the Neuregulin (NRG) ErbB signaling pathway. Importantly, genes encoding the neurotrophic factors NRG-1 and NRG-3, as well as their receptor ErbB4, were identified as "at risk" genes for schizophrenia and other psychiatric disorders. Using a combination of molecular, cellular, electrophysiological, and behavioral approaches, the SMN found that (i) NRG-1 reverses long-term potentiation at glutamatergic synapses via a novel signaling pathway linking activation of ErbB4 to dopamine release, and (ii) downstream activation of D4 dopamine receptors triggers the rapid internalization of surface glutamate receptors. In collaborative studies, the SMN also showed that NRG-1 signaling modulates gamma oscillatory network activity and that such activity requires ErbB4 receptors expressed in fast-spiking interneurons. The functional link between NRG-1/ErbB4 signaling with glutamatergic transmission and D4 dopamine receptors (a target for clozapine and other antipsychotics), along with its link through GABAergic neurons to modulate gamma oscillation power (reduced in schizophrenia patients), begins to uncover pathways that are genetically, pharmacologically, and functionally implicated in cognitive functions and psychiatric disorders.

​​
Last Updated Date: 11/30/2012
Last Reviewed Date: 11/30/2012

Contact Information

Name: Dr Andres L Buonanno
Senior Investigator
Section on Molecular Neurobiology
Phone: 301-496-0170
Fax: 301-480-2707
Email: buonanno@mail.nih.gov

Staff Directory
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology