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Hinnebusch Lab: Section on Nutrient Control of Gene Expression

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Overview

Members of the Section on Nutrient Control of Gene Expression, headed by Alan Hinnebusch, study mechanisms of transcriptional and translational gene regulation. Recently, they provided evidence that the essential function of the beta subunit of the 5-subunit guanine nucleotide exchange factor eIF2B is to promote binding of the substrate, GDP–bound translation initiation factor 2 (eIF2), for the recycling of eIF2. They also demonstrated that interaction of the poly(A) binding protein (PABP) with eIF4G is dispensable for translation in the presence of the N-terminal RNA–binding domain in eIF4G, implying that mRNA circularization via cap-poly(A) interaction is not fundamentally important in vivo but rather represents only one of several interactions that stabilize eIF4G binding to mRNA. Furthermore, genome-wide analysis revealed that eIF4G is dispensable for the translation of most mRNAs, functioning primarily to boost translation rates several fold. It also plays a modest role in adjusting relative translational efficiencies of mRNAs across the genome.

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Last Updated Date: 11/30/2012
Last Reviewed Date: 11/30/2012

Contact Information

Name: Dr Alan G Hinnebusch
Senior Investigator
Section on Nutrient Control of Gene Expression
Phone: 301-496-4480
Fax: 301-496-6828
Email: hinnebua@mail.nih.gov

Staff Directory
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology