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Machner Lab: Unit on Microbial Pathogenesis

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Overview

The Unit on Microbial Pathogenesis, headed by Matthias Machner, analyzes host-pathogen interactions during Legionnaires' disease, a severe pneumonia caused by the bacterium Legionella pneumophila. Of particular interest are bacterial effector proteins that are delivered, during the infection process, into the host-cell cytosol, where they modulate host signaling processes. The Unit continued its studies aimed at identifying host-cell targets for bacterial effectors, dissecting the effectors' function on a molecular level, and determining the importance of these interactions for Legionella virulence. Major progress was made in the analysis of bacterial effectors that modulate host proteins of the Rab family, small GTPases that function as key regulators of vesicle traffic in eukaryotic cells.

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Last Updated Date: 11/30/2012
Last Reviewed Date: 11/30/2012

Contact Information

Name: Dr Matthias Machner
Tenure Track Investigator
Unit on Microbial Pathogenesis
Phone: 301-435-8417
Fax: 301-402-0078
Email: machnerm@mail.nih.gov

Staff Directory
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology