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Lilly Lab: Section on Gamete Development

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Overview

The Section on Gamete Development, led by Mary Lilly, examines cell-cycle regulation during oogenesis. Over the past year, the Section continued to examine the pathways that coordinate meiotic progression with gamete differentiation. From these studies, the Section determined that the p27-like cyclin–dependent kinase inhibitor Dacapo promotes genomic stability during the premeiotic S phase of the oocyte. In addition, the Section identified a new pathway required to maintain mitotic quiescence during the highly conserved prophase I meiotic arrest of the oocyte. Lastly, the Section defined the role of a structural nucleoporin in promoting ovarian cyst divisions and the assembly of the meiosis I spindle.

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Last Updated Date: 11/30/2012
Last Reviewed Date: 11/30/2012

Contact Information

Name: Dr Mary Lilly
Investigator
Section on Gamete Development
Phone: 301-435-8428
Fax: 301-402-0078
Email: mlilly@helix.nih.gov

Staff Directory
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology