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The Section on Intracellular Protein Trafficking, led by Juan Bonifacino, focuses on the molecular machinery involved in protein sorting to endosomes, lysosomes, and related organelles. Research over the past year shed light on the mechanisms by which the human immunodeficiency virus-1 (HIV-1) downregulates expression of the CD4 co-receptor from the surface of the host cells. In addition, the Section showed that the AP-4 complex plays a role in the traffic and processing of the Alzheimer's-disease amyloid precursor protein. Other studies revealed important aspects of the function of the retromer and GARP complexes in protein trafficking between endosomes and the Golgi complex and in lysosome biogenesis.