Skip Internal Navigation
EB Research - Methodological Research in Epidemiology
Biomarker/Analytical Development: Mixtures of Environmental Exposures
With the ever changing production of consumer products, so too are the public's environmental exposure to potential toxicants continuously changing. Often these exposures occur in mixtures, which in turn lead to statistical issues of colinearity and high dimensionality which make it difficult or impossible to distinguish the influences of individual chemicals on health outcomes when studying a chemicals' public health impact.
Researchers here have worked towards developing methods that allow for assessing the effects of these chemicals jointly, reflecting the reality of the public's actual exposure profile, rather than estimating the individual effects of each. These methodological developments are motivated by the understanding of an individual's exposure profile where interactions are implicit. In an effort to overcome the analytical challenges that often leave issues of mixtures ignored, a collaborative effort funded by the American Chemistry Council has been organized with the goal of providing the methodological tools necessary to assess and address the issues of mixtures in the assessment of environmental exposures and their potential role in disease.
Enrique F. Schisterman, Ph.D.
- Buck Louis GM, Sundaram R. Exposome: Time for Transformative Research: Invited Commentary. Statistics and Medicine 2012;31(22):2569-2575. PMID: 22969025
- Buck Louis GM, Yeung E, Sundaram R, Laughon SK, Zhang C. The exposome – exciting opportunities for discoveries in reproductive and perinatal epidemiology. Paediatric and Perinatal Epidemiology,2013; 27(3):229-36. PMID: 23574410