Tuija Ilona Männistö, M.D., Ph.D.
Curriculum vitae, revised March 18, 2013

Office address:

Epidemiology Branch,
Division of Epidemiology, Statistics and Prevention Research
Eunice Kennedy Shriver National Institute of Child Health and Human Development,
National Institutes of Health
6100 Executive Boulevard 7B05
Rockville, MD 20852

Contact information:

Tel: 301-435-6922
email: mannistoti@mail.nih.gov

Date and place of birth: 27 Apr 1985, Merijärvi, Finland

Education

May 2011 PhD
Clinical epidemiology in the field of Obstetrics and Gynecology
Department of Obstetrics and Gynecology and Institute of Health Sciences,
University of Oulu, Oulu, Finland National Institute for Health and Welfare, Oulu, Finland
Dissertation: “Maternal thyroid function during pregnancy. Effects on pregnancy, peri-and neonatal outcome and on later maternal health” in the Northern Finland Birth Cohort 1986 (http://urn.fi/urn:isbn:9789514294037 External Web Site Policy )
February 2010 Licentiate of Medicine (M.D.)
University of Oulu, Oulu, Finland
May 2004 Upper secondary school graduation
Oulainen, Finland

Research experience

Sep 2011-present Visiting postdoctoral fellow, Intramural Research Training Award Epidemiology Branch,
Division of Epidemiology, Statistics and Prevention Research,
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Mentor: Dr. Pauline Mendola
2010-2012Researcher
Northern Finland Birth Cohort 1966
Participation in the development of questionnaire to cohort subjects to be filled out at age of 45 years, with emphasis on gynecological and endocrinological questions
PI: Professor Marjo-Riitta Järvelin
2010-2011 Ph.D. student position
National Graduate School of Clinical Investigation, Helsinki, Finland

Teaching and mentoring experience

February 2011-present Mentor
Ph.D. student Fanni Päkkilä
University of Oulu, Oulu, Finland

Ms. Päkkilä has been honoured with:
Best poster prize, Finnish Medical Association, 2011
Best presentation prize, Finnish Endocrine Society, 2010
Summer 2012Summer student course
Long-term effects of hypertension during pregnancy
NIH, Epidemiology Branch
Fall 2010-spring 2011 Visiting lecturer for biomedical laboratory scientists
Utilization of laboratory measurements in evaluating health
Oulu University of Applied Sciences, Oulu, Finland
Fall 2010 Small group lecturer for medical students
Pre-and postanalytical factors in clinical chemistry and the technique of phlebotomy
Department of Clinical Chemistry, University of Oulu, Oulu, Finland

Work experience

March 2010 - July 2011 Specialising physician in Clinical Chemistry
Oulu University Hospital Laboratory, Oulu, Finland
2009- 2011

General practitioner and emergency department doctor
Oulainen municipal health care centre, Oulainen, Finland
Oulainen occupational medical centre, Oulainen, Finland
Raahe municipal health care centre, Raahe, Finland

2008

Intern in Internal Medicine
Oulaskangas regional hospital, Oulainen, Finland

Awards

March 2013

MVP Award
Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development

19 April 2012 Ulla-Maija Mäkilä Prize for the best thesis in 2011
The Finnish Society of Obstetrics and Gynaecology
May 2011 Young Investigator Award
European Society of Endocrinology

Editorial activities

Reviewer for: Epidemiology, Journal of Clinical Endocrinology and Metabolism, Acta Obstetricia et Gynecologica Scandinavia, North American Journal of Medical Sciences
Grant proposal reviews: Wellbeing of Women Research Training Fellowships

Peer-reviewed publications

Published:

Päkkilä F, Männistö T, Surcel HM, Ruokonen A, Bloigu A, Pouta A, Hartikainen AL, Vääräsmäki M, Järvelin MR, Suvanto S. Maternal thyroid dysfunction during pregnancy and thyroid function of her child in adolescence. J Clin Endocrinol Metab 2013, published online ahead of print. DOI: 10.1210/jc.2012-2028

Männistö T, Mendola P, Vääräsmäki M, Järvelin M-R, Hartikainen A-L, Pouta A, Suvanto E. Elevated blood pressure in pregnancy and subsequent chronic disease risk. Circulation 2013;127(6):681-90. Featured in an editorial: Intapad S and Alexander BT. Future cardiovascular risk: Interpreting the importance of increased blood pressure during pregnancy. Circulation 2013;127(6):668-9. Featured by the American Heart Association: http://newsroom.heart.org/news/high-blood-pressure-during-pregnancy-may-signal-later-heart-disease-risk External Web Site Policy

Mendola P, Laughon SK, Männistö T, Leishear K, Reddy U, Chen Z, Zhang J. Obstetric complications among US women with asthma. Am J Obstet Gynecol 2013;208(2):127.e1-8.

Männistö T, Karumanchi SA, Pouta A, Vääräsmäki M, Mendola P, Miettola S, Surcel HM, Bloigu A, Ruokonen A, Järvelin MR, Hartikainen AL, Suvanto E. Preeclampsia, gestational hypertension and subsequent hypothyroidism. Pregnancy Hypertens 2013;3(1):21-27.

Männistö T, Hartikainen AL, Vääräsmäki M, Bloigu A, Surcel HM, Pouta A, Järvelin MR, Ruokonen A, Suvanto E. Smoking and early pregnancy thyroid hormone and antibody levels in euthyroid mothers of Northern Finland Birth Cohort 1986. Thyroid 2012;22(9):944-950.

Männistö T, Surcel H-M, Ruokonen A, Vääräsmäki M, Pouta A, Bloigu A, Järvelin M-R, Hartikainen A-L, Suvanto E Early pregnancy reference intervals of thyroid hormone concentrations in a thyroid antibody-negative pregnant population. Thyroid 2011;21(3):291-298.

Männistö T, Vääräsmäki M, Pouta A, Hartikainen AL, Ruokonen A, Surcel HM, Bloigu A, Järvelin MR, Suvanto E. Thyroid dysfunction and antibodies during pregnancy as predictive factors of pregnancy complications and maternal morbidity in later life. J Clin Endocrinol Metab 2010;95(3):1084-1094.

Aakre KM, Bliksrud YT, Frøyshov BM, Hager HB, Hansen ASV, Janukonyte J, Lauterlein JJ, Lilleholt K, Løhne K, Männistö T, Miettola S, Pelanti J, Samson MH, Skauby RH, Tuuti E, Zelvyte I. Validation of the Hemo_Control instrument for determination of B-haemoglobin concentration in primary health care. Scand J Clin Lab Invest 2009;69(8):817-821.

Männistö T, Vääräsmäki M, Pouta A, Hartikainen AL, Ruokonen A, Surcel HM, Bloigu A, Järvelin MR, Suvanto-Luukkonen E. Perinatal outcome of children born to mothers with thyroid dysfunction or antibodies: A prospective population-based cohort study. J Clin Endocrinol Metab 2009;94(3):772-779.

In press:

Werder E, Mendola P, Männistö T, O'Laughlin J, Laughon SK. Effect of maternal chronic disease on obstetric complications in twin pregnancies in a U.S. cohort. Fertility and Sterility 2013

Männistö T, Mendola P, Reddy U, Laughon SK. Neonatal outcomes and birth weight in pregnancies complicated by maternal thyroid disease. Am J Epidemiol 2013

Submitted:

Männistö T, Mendola P, Grewal J, Xie Y, Chen Z, Laughon SK. Thyroid diseases and adverse pregnancy outcomes in a contemporary observational cohort from the United States.

Ghosh G, Laughon SK, Mendola P; Männistö T, Chen Z, Xie Y, Grewal J. Racial/ethnic differences in pregnancy-related hypertensive disease in nulliparous women.

Päkkilä F, Männistö T, Pouta A, Hartikainen A-L, Ruokonen A, Surcel H-M, Bloigu A, Vääräsmäki M, Järvelin M-R, Moilanen I, Suvanto E. The impact of gestational thyroid hormone concentrations on ADHD symptoms of the child

Editorials:

Männistö T. Invited editorial: Is there enough evidence of poor fetal growth to merit narrowing free T4 reference ranges during pregnancy? J Clin Endocrinol Metab 2013:98(1):43-44.

Männistö T, Suvanto E, Vääräsmäki M, Ebeling T. Pitäisikö jokaiselta raskautta haluavalta naiselta tutkia seerumin tyreotropiini ja tyreoideaperoksidaasivasta-aineet? (Editorial, Finnish) Duodecim 2010; 126(20):2421-3.

Letters to editors:

Männistö T, Vääräsmäki M, Suvanto E. Pregnancy outcomes in women with thyroid peroxidase antibodies. Obstet Gynecol. 2011;117(1):174-5;

Männistö T, Suvanto E, Surcel HM, Ruokonen A. Thyroid hormones are stable even during prolonged frozen storage. Clin Chem Lab Med. 2010;48(11):1669-70.

Männistö T, Surcel HM, Bloigu A, Ruokonen A, Hartikainen AL, Järvelin MR, Pouta A, Vääräsmäki M, Suvanto-Luukkonen E. The Effect of Freezing, Thawing, and Short- and Long-Term Storage on Serum Thyrotropin, Thyroid Hormones, and Thyroid Autoantibodies: Implications for Analyzing Samples Stored in Serum Banks.Clin Chem 2007;53:1986-1987.

Other publications:

Pirkko Tuominen (editor). Kilpirauhanen ja odotus. Expert opinion on thyroid function during pregnancy (Finnish). Vauva magazine 01/2012.

Presentations (*presented by students working with Dr. Männistö)

Männistö T, Mendola P, Vääräsmäki M, Pouta A, Järvelin M-R, Hartikainen A-L, Suvanto E. Maternal health after gestational hypertension in Northern Finland Birth Cohort 1966. 25th Anniversary Meeting of Society for Pediatric and Perinatal Epidemiologic Research, Minneapolis, MN, USA, June 25-27, 2012.

*Päkkilä F, Männistö T, Bloigu A, Vääräsmäki M, Hartikainen A-L, Ruokonen A, Pouta A, Järvelin M-R, Surcel HM, Suvanto E. Maternal thyroid dysfunction during pregnancy and thyroid function of the offspring at the age of 16 years. 64th Annual Meeting of Finnish Endocrine Society, Helsinki, Finland, October 27-28 2011

Männistö T, Ruokonen A, Surcel HM, Bloigu A, Vääräsmäki M, Pouta A, Järvelin MR, Hartikainen AL, Suvanto E. Smoking habits and early pregnancy thyroid hormone and antibody levels. European Congress of Endocrinology, Rotterdam, the Netherlands, April 30-May 4, 2011

*Päkkilä F, Männistö T, Bloigu S, Vääräsmäki M, Hartikainen AL, Ruokonen A, Pouta A, Järvelin MR, Surcel HM, Suvanto E. Maternal thyroid dysfunction during pregnancy and thyroid function of the offspring at the age of 16 years. European Congress of Endocrinology, Rotterdam, the Netherlands, April 30-May 4, 2011

Männistö T, Vääräsmäki M, Pouta A, Hartikainen AL, Ruokonen A, Surcel HM, Bloigu A, Järvelin MR, Suvanto E. äidin kilpirauhasen toimintahäiriö raskauden aikana. Vaikutukset raskauskomplikaatioiden esiintymiseen sekä äidin myöhempään sairastavuuteen. Young Epidemiologist competition, finalist presentation, Finnish Society of Epidemiology, Helsinki, Finland, February 22, 2011

Männistö T, Vääräsmäki M, Pouta A, Hartikainen AL, Ruokonen A, Surcel HM, Bloigu A, Järvelin MR, Suvanto E. Thyroid dysfunction during pregnancy, effects on pregnancy and perinatal outcome.The Scientific Conference of the Medical Faculty, Tartu, Estonia, October 7, 2010

Männistö T, Surcel H-M, Ruokonen A, Vääräsmäki M, Pouta A, Bloigu A, Järvelin M-R, Hartikainen A-L & Suvanto E Early pregnancy reference intervals of thyroid hormone concentrations in a thyroid antibody-negative pregnant population. Meetings of National Graduate School of Clinical Investigation, Tuorla, Finland, April 14, 2010

Männistö T, Vääräsmäki M, Pouta A, Hartikainen AL, Ruokonen A, Surcel HM, Bloigu A, Järvelin MR, Suvanto E. Thyroid dysfunction and antibodies during pregnancy as predictive factors of pregnancy complications and maternal morbidity in later life. Meetings of National Graduate School of Clinical Investigation, Biomedicum, Helsinki, Finland, January 11, 2010

Männistö T, Vääräsmäki M, Pouta A, Hartikainen AL, Ruokonen A, Surcel HM, Bloigu A, Järvelin R, Suvanto-Luukkonen E. Thyroid dysfunction and antibodies during pregnancy as a predictive factor for pregnancy complications and mothers' morbidity in later life. 62nd Annual Meeting of the Finnish Endocrine Society, Helsinki, Finland, October 15-16, 2009

Männistö T, Vääräsmäki M, Pouta A, Hartikainen AL, Ruokonen A, Surcel HM, Bloigu A, Järvelin R, Suvanto-Luukkonen E. Thyroid dysfunction and antibodies during pregnancy as a predictive factor for pregnancy complications and mothers' morbidity in later life. 8th Congress of European Society of Gynecology, Rome, Italy, September 10-13, 2009

Männistö T. Raskauden aikainen kilpirauhasen toimintahäiriö — vaikutukset äitiin ja lapseen. Meeting of Northern Gynecologists, Oulu, Finland, Feb 7, 2009

Männistö T, Vääräsmäki M, Pouta A, Hartikainen AL, Ruokonen A, Surcel HM, Bloigu A, Järvelin MR, Suvanto E. Perinatal outcome of children born to mothers with thyroid dysfunction or antibodies. A prospective population-based cohort study. (Focus on ethical aspects of the study). The 6th International Kastelli Symposium, Oulu, Finland, November 20-21, 2008

Männistö T, Vääräsmäki M, Pouta A, Hartikainen AL, Ruokonen A, Surcel HM, Bloigu A, Järvelin MR, Suvanto-Luukkonen E. Perinatal outcome of children born to mothers with thyroid dysfunction. A prospective population-based cohort study. 61st Annual Meeting of the Finnish Endocrine Society, Helsinki, Finland, October 30-31, 2008

Männistö T, Vääräsmäki M, Pouta A, Hartikainen AL, Ruokonen A, Surcel HM, Bloigu A, Järvelin MR, Suvanto-Luukkonen E. Perinatal outcome of children born to mothers with thyroid dysfunction. A prospective population-based cohort study. 36th Congress of Nordic Federation of Societies of Obstetrics and Gynecology, Reykjavik, Iceland, June 14-17, 2008

Poster presentations:

Mendola P, Laughon SK, Männistö T, Zhang J, Leishear K, Reddy U, Chen Z. Pregnancy complications associated with asthma. Annual Meeting of the American College of Epidemiology, Chicago, IL, September 8-11, 2012. (Published in Ann Epidemiol 2012;22(9):676).

*Werder E, Mendola P, Männistö T, O'Loughlin J, Laughon SK. Maternal chronic disease and pregnancy complications among twin pregnancies in the Consortium on Safe Labor (2002-2008). NIH summer research program poster day, NIH, Bethesda, MD, August 9, 2012

*O'Loughlin JA, Laughon SK, Mendola P, Männistö T, Xie Y, Chen Z, Werder E, Ehrenthal D, Kiely M. The effect of maternal psychiatric illness on length of gestation. NIH summer research program poster day, NIH, Bethesda, MD, August 9, 2012

Männistö T, Mendola P, Vääräsmäki M, Pouta A, Järvelin MR, Hartikainen AL, Suvanto E. Women's health after gestational hypertension in Northern Finland Birth Cohort 1966. 45th Annual Meeting of Society of Epidemiologic Research, Minneapolis, MN, USA, June 27-30, 2012. (Published in Am J Epidemiol 2012;175(11 suppl):S135).

*Ghosh G, Laughon SK, Mendola P, Chen Z, Männistö T, Xie Y, Grewal J. Racial/ethnic differences in pregnancy related hypertensive disease among nulliparous women. 45th Annual Meeting of Society of Epidemiologic Research, Minneapolis, MN, June 27-30, 2012

*Ghosh G, Laughon SK, Mendola P, Chen Z, Männistö T, Xie Y, Grewal J. Racial/ethnic differences in pregnancy related hypertensive disease among nulliparous women. Office of Intramural Training and Education Post Baccalaureate Poster Day, National Institutes of Health, Bethesda, MD, April 25, 2012.

*Päkkilä F, Männistö T, Bloigu A, Vääräsmäki M, Hartikainen AL, Ruokonen A, Pouta A, Järvelin MR, Surcel HM, Suvanto E. Maternal thyroid dysfunction during pregnancy and thyroid function of the offspring at the age of 16 years. The Finnish Medical convention 2012, Helsinki, Finland, Jan 9-12 2012

Suvanto-Luukkonen E, Männistö T, Hartikainen AL, Vääräsmäki M, Ruokonen A, Järvelin MR, Pouta A. Is self-reported thyroid dysfunction an obstetrical risk factor? The Meeting of Finnish Medical Association, Helsinki, Finland, January 7-10, 2008

Männistö T, Surcel HM, Bloigu A, Ruokonen A, Hartikainen AL, Järvelin MR, Pouta A, Vääräsmäki M, Suvanto-Luukkonen E. The effect of freezing and long-term storage on serum thyrotropin, thyroid hormones and autoantibodies. 32nd Annual Meeting of the European Thyroid Association, Leipzig, Germany, September 1-5, 2007

Suvanto-Luukkonen E, Männistö T, Hartikainen AL, Vääräsmäki M, Ruokonen A, Järvelin MR, Pouta A. Is self-reported thyroid dysfunction an obstetrical risk factor? 32nd Annual Meeting of the European Thyroid Association, Leipzig, Germany, September 1-5, 2007

Männistö T, Surcel HM, Bloigu A, Ruokonen A, Hartikainen AL, Järvelin MR, Pouta A, Vääräsmäki M, Suvanto-Luukkonen E.. The effect of freezing and long-term storage on serum thyrotropin, thyroid hormones and autoantibodies. The 5th Science Day of Faculty of Medicine, University of Oulu, Oulu, Finland, February 13, 2007

Professional affiliations

Society of Epidemiologic Research (2012- )
Society of Pediatric and Perinatal Epidemiology (2012- )
European Society of Endocrinology (2011- )
Finnish Society of Endocrinology (2011- )
Finnish Society of Epidemiology (2011- )
Finnish Society of Obstetrics and Gynecology (2010- )
Finnish Society of Perinatology (2010- )
Finnish Society of Clinical Chemistry (2010- )
The Finnish Medical Association (2006- )
The Finnish Medical Society Duodecim (2008- )
Finnish Society for Young Medical Doctors (2006- )

Professional development

Introduction to Linux, CIT Training, National Institutes of Health (NIH) (January 9, 2013)

Webinar: Measuring Steroids and Hormones by MS/MS, Elsevier (December 7, 2012)

Thyroid disorders: Recent Clinical Advances 2012, MedStar Washington Hospital Center, Washington DC (December 7, 2012)

2nd Annual Epidemiologic Methods Application e-Conference, Society of Epidemiologic Research (November 17, 2012)

Webinar: Measuring designer drugs of abuse, Elsevier (October 29, 2012)

NCI Cohort Consortium Symposium, “When Bigger is Better: Combining & Designing Cohorts for Power”, National Institutes of Health (October 25, 2012)

Webinar: Exactive plus high resolution MS for quan/qual analysis — A focus on quantification in clinical research labs, Elsevier (September 27, 2012)

The Ethical and Regulatory Aspects of Clinical Research, NIH (fall 2012)

Computing for Data Analysis, Johns Hopkins Bloomberg School of Public Health, online course (fall 2012)

Media and Presentation Training, Oratorio Media, Washington D.C. (August 9, 2012)

A Grand Opportunity: Developing a Resource for Genetic Epidemiology Research in Adult Health and Aging, NIH (June 4, 2012)

Mentoring course, Office of Intramural Training and Education, NIH (Summer 2012).

Scientists teaching science, Office of Intramural Training and Education, NIH (Spring 2012).

Medicine: Mind the Gap seminar series: The Evidence-to-Practice Gap: Teaching Clinicians Evidence-based Medicine (May 17 2012); The Pressure To Get It Right: Biases in Biomedical Research (March 19, 2012)

Short Course on Longitudinal Data Analysis, NIH, DESPR, Rockville, MD (April 5-6, 2012)

Workplace dynamics — Gaining self-awareness and communication skills, managing conflict and team skills, Office of Intramural Training and Education, NIH (February-April 2012)

Courageous Decision Making workshop, NICHD, NIH (January 10, 2012)

Emerging Technologies for Measuring Individual Exposomes, Washington D.C. (December 8-9, 2011)

Media Training, Oratorio Media, Washington D.C. (November 2, 2011)

Measurement Error In Dietary Intake Data Webinar Series, Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health (September — December, 2011)

Quality Data from Pediatric Clinical Trials Workshop, NICHD, NIH (October 21, 2011)

Advance course in protein chemistry/proteomics, Biomedicum, Helsinki, Finland (May, 2011)

Tropical diseases and parasites - Trooppiset taudit ja parasiitit suomalaisen lääkärin näkökulmasta, University of Oulu (Spring 2011)

Leadership training for specializing medical doctors, University of Oulu, Oulu, Finland (fall 2010-spring 2011)

Lab quality —days, Helsinki, Finland (February 10-11, 2011)

Course in Manuscript Writing, Editorial Board of Scandinavian Journal of Clinical and Laboratory Investigation, Finse, Norway (January 29th - February 1st, 2008)

Software

SPSS, SAS, Reference Manager, Endnote, GIMP (basic) and Microsoft Office

Language skills

Finnish Native
English Fluent
Swedish Good
German Good
Russian Basics

Non-professional Affiliations

Red Cross of Finland, Oulunsuu First Aid Group