Ruzong Fan, Ph.D

Date:

August 29, 2013

Current Position:

Investigator
Biostatistics and Bioinformatics Branch
Division of Intramural Population Health Research
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health
Bethesda, MD 20892

Address:

6100 Executive Blvd, Room 7B07J, MSC 7510
Bethesda, MD 20892-7510
fanr@mail.nih.gov

Education:

Research Interests:

NIH Experience:

Previous Academic Appointments:

Other Working Experience:

Membership:

Academic and Professional Awards:

Steering Committee of Workshops:

Organizer of Statistical Meeting Sessions:

Chair of Statistical Meeting Sessions:

Software Development:

Refer to http://www.nichd.nih.gov/about/org/diphr/bbb/software/Pages/default.aspx

Research Grants:

Grant Reviews:

Mentoring at NIH:

Mentoring at Texas A&M:

Teaching Experience:

Referee for Scientific Papers:

Research Monograph:

Refereed Manuscripts:

  1. Lobach I, Fan RZ, and Manga P (2013) Genotype-Based association models of complex diseases to detect gene-gene and gene-environment interactions. Statistics and Its Interface, in revision.
  2. 2Fan RZ, Wang YF, Mills JL, Wilson AF, Bailey-Wilson JE, and Xiong MM (2013) Functional linear models for association analysis of quantitative traits. Genetic Epidemiology 37: 726-742.
  3. Fan RZ, Lee A, Liu AY, Troendle J, and Mills JL (2013) Association analysis of complex diseases using triads, parent-child dyads and singleton monads. BMC Genetics 14:78. DOI: 10.1186/10.1186/1471-2156-14-78.
    URL: http://www.biomedcentral.com/1471-2156/14/78 External Web Site Policy.
  4. Feenstra B, Geller F, Carstensen L, Romitti PA, Korberg IB, Bedell B, Krogh C, Fan RZ, Svenningsson A, Caggana M, Nordenskjold A, Mills JL, Murray JC, Melbye M (2013) Plasma lipids, chromosome 11q23.3, and the risk of infantile hypertrophic pyloric stenosis. The Journal of American Medical Association 310(7): 714-721. doi:10.1101/jama.2013.242978.
  5. Fan RZ, Zhang YW, Albert PS, Liu AY, Wang YJ, and Xiong MM (2012) Longitudinal association analysis of quantitative traits. Genetic Epidemiology 36:856-869.
  6. Lobach I, Fan RZ (2012) Genotype-based Bayesian analysis of gene-environment interactions with multiple genetic markers and misclassification in environmental factors. Journal of Probability and Statistics, Volume 2012, Article ID 151259, 15 pages, doi:10.1155/2012/151259.
  7. Mechanic LE, Chen HS, Amos CI, Chatterjee N, Cox NJ, Divi RL, Fan RZ, Harris EL, et al. (2012) Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. Genetic Epidemiology 36:22-35.
  8. Fan RZ, Zhong M, Wang SF, Zhang YW, Andrew A, Karagas M, Chen H, Amos CI, Xiong M, and Moore J (2011) Entropy-based information gain approaches to detect and to characterize gene-gene and gene-environment interactions/correlations of complex diseases. Genetic Epidemiology 35:706-721.
  9. Zhong M, Zhang YW, Lange K, and Fan RZ3 (2011) A cross-population extended haplotype-based homozygosity score test to detect positive selection in genome-wide scans. Statistics and Its Interface 4:51-63.
  10. Lobach I, Fan RZ4, and Carroll RJ (2010) Genotype-based association mapping of complex diseases: a case-control approach of gene-environmental interactions with multiple markers and measurement errors in environmental exposures. Genetic Epidemiology 34:792-802.
  11. Zhong M, Lange K, Papp JC, and Fan RZ5 (2010) Extended homozygosity score tests to detect positive selection in genome-wide scans. European Journal of Human Genetics 18:1148-1159.
  12. Massett MP, Fan RZ, and Berk BC (2009) Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice. Physiological Genomics 40:15-22.
  13. Chen LF, Zhong M, Chen WV, Amos C, and Fan RZ6 (2009) A genome-wide association scan for rheumatoid arthritis data by Hotelling's T 2 tests. BMC Proceedings 3 (Suppl 7):S6.
  14. Thomas NJ, DiAngelo S, Hess JC, Fan RZ, Ball MW, Geskey JM, Willson DF, and Floros J (2009) Transmission of surfactant protein variants and haplotypes in children hospitalized with respiratory syncytial virus. Pediatric Research 66:70-73.
  15. Jung JS, Zhong M, Liu L, and Fan RZ7 (2008) Bi-variate combined linkage and association mapping of quantitative trait loci. Genetic Epidemiology 32:396-412.
  16. Fan RZ, Liu L, Jung J, and Zhong M (2008) Combined linkage and association mapping of quantitative trait loci with missing completely at random genotype data. Behavior Genetics 38:316-336. .
  17. Yang Q, Biernacka JM, Chen MH, Houwing-Duistermaat JJ, Bergemann TL, Basu S, Fan R, Liu L, Bourgey M, Clerget-Darpoux F, Lin WY, Dupuis J, Elston RC, and Cupples LA (2007) Group 4: using linkage and association to identify and model genetic effects. Genetic Epidemiology 31 (Supplement 1):s34-s42.
  18. Thomas NJ, Fan RZ, DiAngelo S, Hess JC, and Floros Y (2007) Haplotypes of the surfactant protein genes A and D as susceptibility factors for the development of respiratory distress syndrome. Acta Paediatrica 96:985-989.
  19. Pavlovic J, Papagaroufalis C, Xanthou M, Liu W, Fan RZ, Thomas NJ, Apostolidou I, Papathoma E, Megaloyianni E, DiAngelo S, and Floros J (2006) Genetic variants of surfactant proteins A, B, C, and D in Bronchopulmonary Dysplasia. Disease Markers 22:277-291.
  20. Floros J, Thomas N, Liu W, Papagaroufalis C, Xanthou M, Pereira S, Fan RZ, Guo X, DiAngelo S, and Pavlovic J (2006) Family-based association tests suggest linkage between SP-B (and flanking region) and RDS; SP-B haplotypes and alleles from SP-B-linked loci are risk factors for RDS. Pediatric Research 59:616-621.
  21. Fan RZ, Jung JS, and Jin L (2006) High resolution association mapping of quantitative trait loci, a population based approach. Genetics 172:663-686.
  22. Fan RZ and Knapp M (2005) Sib-ship T 2 association tests of complex diseases for tightly linked markers. Human Genomics 2:90-112.
  23. Fan RZ, Knapp M, Wjst M, Zhao CX, and Xiong MM (2005) High resolution T 2 Jung JS, Fan RZ, and Jin L (2005) Combined linkage and association mapping of quantitative trait loci by multiple markers. Genetics 170:881-898.
  24. association tests of complex diseases based on family data. Annals of Human Genetics 69:187-208.
  25. Fan RZ, Spinka C, Jin L, and Jung JS (2005) Pedigree linkage disequilibrium mapping of quantitative trait loci. European Journal of Human Genetics 13:216-231.
  26. Fan RZ and Jung SJ (2004) High resolution joint linkage disequilibrium and linkage mapping of quantitative trait loci based on sibship data. Human Heredity 56:166-187.
  27. Fan RZ and Knapp M (2003) Genome association studies of complex diseases by case-control designs. American Journal of Human Genetics 72:850-868.
  28. Fan RZ and Xiong MM (2003) Combined high resolution linkage and association mapping of quantitative trait loci. European Journal of Human Genetics 11:125-137.
  29. Fan RZ and Xiong MM (2003) Linkage and association studies of QTL for nuclear families by mixed models. Biostatistics 4:75-95.
  30. Fan RZ and Jung SJ (2003) Association studies of QTL for multi-allele markers by mixed models. Human Heredity 54:132-150.
  31. Fan RZ and Xiong MM (2002) High resolution mapping of quantitative trait loci by linkage disequilibrium analysis. European Journal of Human Genetics 10:607-615.
  32. Xiong MM, Fan RZ, and Jin L (2002) Linkage disequilibrium mapping of quantitative trait loci under truncation selection. Human Heredity 53:158-172.
  33. Fan RZ, Floros J, and Xiong MM (2002) Models and tests of linkage and association studies of QTL for multi-allele marker loci. Human Heredity 53:130-145.
  34. Fan RZ, Floros J, and Xiong MM (2001) Linkage transmission disequilibrium test of two unlinked disease loci; application to respiratory distress syndrome. Advances and Applications in Statistics 1:277-308.
  35. Floros J, Fan RZ, Diangelo S, Guo XX, Wert J, and Luo JM (2001) SP-B associations and interactions with SP-A in RDS in whites and blacks. Pediatric International 43:567-576.
  36. Floros J, Fan RZ, Matthews A, DiAngelo S, Luo JM, Nielsen H, Dunn M, Gewolb I, Koppe J, vanSonderen L, Farri-Kostopoulos L, Ramet M, Merrill J, and Robbins (2001) Family based transmission disequilibrium test (TDT) and case-control association studies reveal surfactant protein A (SP-A) susceptibility alleles for respiratory distress syndrome (RDS) and possible race differences. Clinical Genetics 60:178-187.
  37. Floros Y and Fan RZ (2001) Surfactant protein (SP) B associations and interactions with SP-A in whites and black subjects with respiratory distress syndrome. Pediatric International 43:567-576. Biology of the Neonate 80 (Suppl 1):22-25.
  38. Fan RZ and Lange K (2000) Asymptotic properties of the maximal subinterval of a Poisson process. Stochastic Processes, Physics and Geometry: New Interplays. II: A Volume in Honor of Sergio Albeverio; Conference Proceedings, Canadian Mathematical Society, Volume 29; edited by Gesztesy F, Holden H, Jost J, Paycha S, Rockner M, and Scarlatti S; pp 175-187.
  39. Fan RZ and Lange K (1999) Diffusion process calculations for mutant genes in non-stationary populations. Statistics in Molecular Biology and Genetics, Institute of Mathematical Statistics, Lecture Notes-Monograph Series, Volume 33, Published by the Institute of Mathematical Statistics and the American Mathematical Society; Ed. Seillier-Moiseiwitsch F, pp 38-55.
  40. Fan RZ, Lange K, and Pena E (1999) Applications of a formula for the variance function of a stochastic process. Statistics & Probability Letters 43-2:123-130.
  41. Fan RZ and Lange K (1998) Models for haplotype evolution in a nonstationary population. Theoretical Population Biology 53:184–198.
  42. Lange K and Fan RZ (1997) Branching process models for mutant genes in nonstationary populations. Theoretical Population Biology 51:118–133; Erratum, Theoretical Population Biology 52:165.
  43. Fan RZ (1996) Potential theory of hyperfinite Dirichlet forms. Potential Analysis, Netherlands 5:417–462.
  44. Albeverio S, Fan RZ, Rockner M, and Stannat W (1995) A remark on coercive forms and associated semigroups. Partial Differential Equations and Mathematical Physics (Series: Operator Theory: Advances and Applications, Vol. 78, Birkhauser Verlag, Basel/Switzerland), Eds. Demuth M and Schulze B, pp 1–8.
  45. Albeverio S and Fan RZ (1995) Representation of martingale additive functionals and absolute continuity of infinite dimensional symmetric diffusions. Dirichlet Forms and Stochastic Processes, Proceedings of the International Conference in Beijing, Eds. Ma ZM, Rockner M, and Yan J, pp 25–45.
  46. Fan RZ (1995) Nonstandard construction of symmetric strong Markov processes associated with Dirichlet forms. Stochastic Processes, Physics and Geometry II, Proceeding of the International Conference in Locarno, Switzerland, Eds Albeverio S, Cattaneo U, and Merlini D, pp 247–277.
  47. Fan RZ (1992) Some diffusion processes on the half-space and their associated Dirichlet forms (in Chinese). Acta Mathematica Sinica 35:418–430.
  48. Fan RZ (1992) Decomposition of a class of functionals and the predictable representation theorem on Banach spaces. Acta Mathematicae Applicatae Sinica, English Series 8:153–167.
  49. Fan RZ (1992) Beurling-Deny formulae on Banach spaces. Acta Mathematica Scientia 12:79–84.
  50. Fan RZ (1991) Decomposition of a class of functionals. Acta Mathematica Sinica, New Series 7:224–240.
  51. Fan RZ (1991) Closabilities of certain symmetric forms on Banach spaces (in Chinese). Chinese Annals of Mathematics 12A:202–209.
  52. Fan RZ (1990) Representation of martingale additive functionals on Banach spaces. Acta Mathematicae Applicatae Sinica, English Series 6:74–80.
  53. Fan RZ (1989) An extension of Dynkin formula and probabilistic solutions of some second-order partial differential equations (in Chinese). Journal of Yunnan University, Natural Science Edition 11:10–14.
  54. Fan RZ (1987) A class of stochastic differential equations with local time and the skew Brownian motion with two barriers (in Chinese). Chinese Journal of Applied Probability and Statistics 3:130–136.

Invited Commentaries

  1. Fan RZ, Albert PS, and Schisterman EF (2012) A discussion of longitudinal genetic analysis as well as gene-gene and gene-environment interactions of complex traits. Statistics in Medicine 31:2565-2568.

Invited Book Reviews:

  1. Fan RZ (2012) Statistics in Human Genetics and Molecular Biology, by Cavan Reilly. The American Statistician 66:71-72.
  2. Fan RZ (2013) The Fundamentals of Modern Statistical Genetics, by Nan M. Laird and Christoph Lange. Journal of the American Statistical Association 108:355.

Posters and Abstracts:

  1. Fan RZ, Jin L, and Xiong MM (2000) Haplotype linkage disequilibrium mapping of quantitative trait loci under truncation selection. The American Journal of Human Genetics 67 (Supplementary 2):319; The American Society of Human Genetics 50th Annual Meeting, abstract 1767.
  2. Floros J, Fan RZ, Guo X, Mattews A, Luo J (2000) Family based transmission disequilibrium test reveals linkage between an SP-B-linked locus and RDS; SP-B linked alleles are susceptibility or protection factors for RDS. The American Journal of Human Genetics 67 (Supplementary 2):357; The American Society of Human Genetics 50th Annual Meeting, abstract 1996.
  3. Fan RZ and Xiong MM (2001) Combined linkage and association interval mapping of quantitative trait loci. The American Journal of Human Genetics 69 (Supplementary):396; The American Society of Human Genetics 51st Annual Meeting, abstract 1252.
  4. Fan RZ and Xiong MM (2002) Haplotype linkage disequilibrium mapping of quantitative trait loci. The American Journal of Human Genetics 71 (Supplementary):572; The American Society of Human Genetics 52nd Annual Meeting, abstract 2360.
  5. Fan RZ, Knapp M, Zhao C, Xiong M (2004) High resolution T 2 association tests of complex diseases using parents as controls. The American Journal of Human Genetics 73 (Supplementary):609; The American Society of Human Genetics 53rd Annual Meeting, abstract 2588.
  6. Fan RZ and Knapp M (2004) High resolution T 2 association tests of complex diseases using normal sibs as controls. The American Society of Human Genetics 54th Annual Meeting, abstract 1989/F3, page 365.
  7. Fan RZ, Liu L, Jung J, and Zhong M (2008) Multivariate combined linkage and association mapping of quantitative trait loci. The 18th International Genetic Epidemiology Society Annual Meeting.
  8. Fan RZ, Zhong M, and Lange K (2009) A powerful extended homozygosity score test to detect positive selection in genome-wide scans. The American Society of Human Genetics 59th Annual Meeting.
  9. Fan RZ, Zhong M, Wang SF, Zhang YW, Andrew A, Karagas M, Moore J, Chen H, Amos CI, and Xiong M (2011) Entropy-based approaches to detect gene-gene and gene-environment interactions of complex diseases. The 12th International Congress of Human Genetics and The American Society of Human Genetics 61st Annual Meeting, 725W.
  10. Pratt CA, Iannotti RJ, Li KG, D'Elio M, Olson S, Lipsky L, Fan RZ, and Simons-Morton B, (2012) Associations among body mass index, waist circumference, dietary factors and cardiometabolic risks in 10th grade students: The NEXT Generation Health Study. The Experimental Biology.
  11. Ronald IJ, Pratt C Li KG, DElio M, Olson S, Fan RZ, and Simons-Morton B. (2013) The role of weight status in associations of adolescent physical activity and sedentary behavior with cardiovascular risk indicators. The International Society for Behavioral Nutrition and Physical Activity.

Invited Talks and Seminars

  1. June 2013, Generalized Functional Linear Models for Case-Control Association Studies, The Joint Conference by the International Chinese Statistical Association (ICSA) and the International Society for Biopharmaceutical Statistics (ISBS), Washington, DC.
  2. May 2013, Functional Linear Models for Association Analysis of Quantitative Traits, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
  3. September 2012, Statistical Analysis of Complex Traits, Washington Statistical Society/ NCI Division of Cancer Prevention Colloquia Series.
  4. June 2012, Stochastic Dynamic Models and Chebyshev Splines, The 21st Applied Statistics Symposium, International Chinese Statistical Association, Boston, MA.
  5. June 2011, extended homozygosity score tests to detect positive selection in genome-wide scans. School of Statistics and Mathematics, Yunnan University of finance and Economics, Kunming, China.

  6. June 2011, entropy-based information gain approaches to detect gene-gene and gene-environment interactions/correlations of complex diseases. Department of Statistics, Yunnan University, Kunming, China.
  7. February 2011, entropy-based information gain approaches to detect gene-gene and gene-environment interactions/correlations of complex diseases. Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH.
  8. October 2010, National Cancer Institute, NIH.
  9. June 2010, Division of Intramural Research Programs, National Institute of Mental Health, NIH.
  10. May 2010, Child Psychiatry Branch, National Institute of Mental Health, NIH.
  11. October 2009, National Cancer Institute, NIH.
  12. October 2008, Division of Biostatistics, University of Minnesota, MN.
  13. September 2008, MD Anderson Cancer Center, The University of Texas, Houston.
  14. December 2007, Mt Sinai Medical School, New York, NY.
  15. December 2007, Columbia University, New York, NY.
  16. February 2007, UCLA, CA.
  17. August 2006, Bonn University, Germany
  18. May 2006, University of Alabama at Birmingham, AL.
  19. March 2006, Stanford University, CA.
  20. September 2005, Case Western Reserve University, OH.
  21. July 2004, University of Bonn, Germany.
  22. June 2002, Hawaii International Conferences on Statistics, HI.
  23. March 2000, Department of Statistics, Penn State University, College Park, PA.
  24. May 1999, Department of Health Evaluation Sciences, Penn State University, Hershey, PA.
  25. May 1999, Department of Biostatistics, University of Iowa, Iowa City, IA.
  26. April 1999, Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA.
  27. March 1999, Department of Biostatistics, University of North Carolina, Chapel Hill, NC.
  28. March 1999, Department of Statistics, University of Georgia, Athens, GA.
  29. March 1999, Anderson Cancer Center, University of Texas, Houston, TX.
  30. June 1998, Department of Environmental Health, Harvard School of Public Health, Boston, MA.
  31. April 1998, Department of Biostatistics, Washington University, St. Louis, MO.
  32. April 1998, Department of Mathematics, University of South California, Los Angeles, CA.
  33. March 1998, Department of Statistics, Iowa State University, Ames, IA.
  34. March 1998, Comprehensive Cancer Center, University of Alabama, Birmingham, AL.
  35. March 1998, Department of Statistics and Department of Biostatistics, University of Wisconsin, Madison, WI.
  36. December 1997, School of Public Health, Columbia University, New York, NY.
  37. September 1993, Department of Mathematics, University of Oslo, Norway.
  38. August 1993, Oberwolfach Conference on Nonstandard Analysis, Germany.
  39. July 1992, International Conference of Nonstandard Analysis, Blaubeuren, Germany.
  40. November 1992, Department of Mathematics, University of Strasburg, France.
  41. September 1991, Department of Mathematics, Humboldt University of Berlin, Germany.
  42. June 1991, International Conference of Stochastic Processes, Physics and Geometry II, Locarno, Switzerland.

Contributed Talks

  1. March 2013, Association Analysis of Complex Diseases Using Triads, Parent-child Dyads and Singleton Monads, International Biometric Society, East North American Region Meeting,Orlando, FL.
  2. August 2012, Joint Statistical Meeting, San Diego, CA.
  3. April 2012, International Biometric Society, East North American Region Meeting, Washington DC.

  4. March 2005, International Biometric Society, East North American Region Meeting, Austin, TX
  5. March 2004, International Biometric Society, East North American Region Meeting, Pittsburgh, PA.
  6. March 2003, International Biometric Society, East North American Region Meeting, Tampa, Florida.
  7. March 2002, International Biometric Society, East North American Region Meeting, Washington, DC.
  8. August 2001, Joint Statistical Meeting, Atlanta, GA.
  9. March 2001, International Biometric Society, East North American Region Meeting, Charlotte, North Carolina.

  1. Authorship is in alphabetical order of the last name. Dr. Fan contributed the first 4 chapters out of 6 as the main contributor.
  2. Dr. Fan and Dr. Wang contribute equally as the first authors.
  3. The corresponding author as a mentor of his Ph.D student, Dr. Zhong M.
  4. The corresponding author. Fan RZ contributed the main idea and did most of the theoretical justification and was responsible to write the paper.
  5. The corresponding author as a mentor of his Ph.D student, Dr. Zhong M.
  6. The corresponding author as a mentor of his master student, Mr. Chen LF.
  7. The corresponding author as a mentor of his students.