Rajeshwari Sundaram, Ph.D., M.Stat.
Investigator, Biostatistics & Bioinformatics Branch
Division of Epidemiology, Statistics & Prevention Research
Eunice Kennedy Shriver National Institute of Child Health
& Human Development
The National Institutes of Health
6100 Executive Blvd., Room 7B05
Rockville, Maryland 20852
|1994-1999 ||Ph.D., Statistics, Michigan State University, East Lansing |
|1991-1993 ||M.Stat. (Applied Statistics & Data Analysis), Indian Statistical Institute, Kolkata |
|1988-1991 ||B.Sc. (Honors), Mathematics, University of Calcutta, India |
- Survival Analysis
- Joint modeling of longitudinal and survival data
- Statistical modeling of human fecundity
- Statistical methods with application to reproductive and environmental
- Investigator, Biostatistics & Bioinformatics Branch, 2006-current
- Assistant Professor, Department of Mathematics, University of North Carolina-Charlotte, 1999-2006
- Statistical Consultant at UNC-Charlotte, Michigan State University
- Teaching Assistant, Michigan State University, Aug. 1994 - July 1996, May 1998July 1999.
- Course Coordinator, Michigan State University, Fall, 1996
Principal Investigator, Eunice Kennedy Shriver National Institute of Child Health and Human Development
||Validation Study of Retrospectively Reported Time-to-Pregnancy Data, LIFE Study; $356,359
Lead Statistician and Co-Investigator, Eunice Kennedy Shriver National Institute of Child Health and Human Development
||Longitudinal Investigation of the Environment and Fertility (LIFE Study); $11,000,000
||Stress and Time to Pregnancy, Oxford Conception Study; $107,000
||Upstate KIDS Study; $7,560,993
||Air Quality and Women’s Reproductive Health. (LIFE Study and Consortium on Safe Labor Study), $494,458
||Upstate KIDS CVD Follow-Up, $5,197,696 (tentative)
Co-Investigator, Eunice Kennedy Shriver National Institute of Child Health and Human Development
||Persistent Environmental Compounds and Gynecologic Health (ENDO Study); $5,300,000
- NIH Merit Award, 2009 for ENDO Study
- NIH Merit Award, 2009 for ingenuity in designing and dedication in completing the LIFE Study
- Junior Faculty Research Grants, UNC-Charlotte, 2000 & 2002
- Association for Women in Mathematics-National Science Foundation Travel Grant for 2002
- Faculty, NICHD-IHDCYH Summer Institute in Reproductive and Perinatal Epidemiology, 2010-present
- Alex McLain (Postdoctoral fellow, North Carolina State University), Postdoctoral fellow, 2009-11, Research Fellow, 2011-2012
- Sung Duk Kim (Postdoctoral student, University of Connecticut), Visiting Post-Doctoral Fellow, Research fellow, November, 2007-March, 2010
Seunggeun Hyun, Pre-Doctoral Fellow 2006-2007
- Won the “Best Student Oral Presentation” award at the Probability and Statistics Day Conference held at University of Maryland Baltimore County, May 2007
- Katahyanee Murray, Pre-Doctoral Fellow of Prevention Research Branch, 2006-2007
Kirsten Lum (MS, American University), Summer Intern, 2007, 2010, Master’s Thesis Advisor, Pre-doctoral Fellow, 2008-2009
- Won the Wray Jackson Smith Scholarship Award (sponsored by American Statistical Association and others) for her work on “Joint modeling of longitudinal data and time to an event: An application to time to pregnancy”
- Elaine Nsoesie (Ph.D., Virginia Tech), Summer Intern, 2007
Graduate courses taught
- Applied Linear Statistical Models, Design of Experiments (sequence course, multiple years)
- Research Topics Course in Survival Analysis
- Theoretical Statistics I –II (sequence course, multiple years)
Undergraduate courses taught
- Elementary Statistics for Business Majors (taught four times)
- Introductory Statistics for Social Sciences (taught ten times)
- Probability and Statistics for Engineers (taught three times)
- Regression Analysis (taught five times)
Master's Projects Supervised:
- Z. Thompson -- Graphical analysis of proportional odds model
- G. Ranganathan -- Analysis of accelerated lifetime model with doubly censored data
- J. Jiang—Properties of Jeffrey’s prior
- X. Guo -- Hazard estimation based on right censored data using Wavelets
- M. Paulraj --Marginal estimation in multistage models based on right censored data
- Associate editor, Biometrics (2009-2013)
- Director of New Professionals, International Indian Statistical Association (2008-)
- Organizer of topic contributed session on “Statistical methods in reproductive epidemiology”, JSM, 2009, 2010
- Co-organizer of a Panel Discussion on research/career opportunities for new professionals, JSM, 2009
- Organizer of a session on “Statistical methods in reproductive and environmental epidemiology”, ENAR, 2011
- Chaired an invited session on “Joint modeling with a view towards risk prediction” at ENAR, 2011
- Organized and Chaired an invited session on “Multistage modeling approach to complex biomedical data”, ENAR 2008
- Moderator of session on Study design and methodological challenges in Preconception Care Research: Improving birth outcomes and reproductive health workshop. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 2008.
- Newsletter Editor, International Indian Statistical Association, 2005-2006
- Member, Search committee for Biostatistics and Bioinformatics Branch, Tenure Track, 2011
- Search committee for Biostatistics and Bioinformatics Branch Chief, 2009
- Search committee for staff scientist, Epidemiology Branch, NICHD, 2008
- Biostatistics & Bioinformatics Branch Representative for IRTA Postdoctoral Review Guidelines Committee, NICHD, 2008
- Planning committee, Preconception Care Workshop, NICHD, 2008
- Committee for Canada-US Collaborative effort on Artificial Reproductive Technology, NICHD, 2008
- Search committee for recruitment of tenure track assistant professor, 2002, 2003
Served on Curriculum Development Committees at University of North Carolina, Charlotte
- Chair, Committee for designing a large enrollment course on introductory statistics course for social sciences majors, 1999-2000
- Committee for development of undergraduate concentration in statistics
- Developed a sequence course (core requirement) on introductory statistics for undergraduate concentration in statistics
- Member, Committee for restructuring Master’s program in Statistics
- Developed a course on “Statistical Computation” for graduate students
- Chair (four semesters) and member (three semesters) of Common Final Exam
- Committee for Introductory Statistics
Adhoc Reviewer for Biometrics, Statistics in Medicine, Journal of Statistical Planning and Inference, Human Reproduction, Environmental Health Perspective, Statistical Methodology
- Statistical challenges in modeling human fecundity. Department of Biostatistics, Johns Hopkins University, November, 2009
- †Monitoring Personal Hormonal Responses to Environmental Exposures, Emerging technologies for measuring individual exposomes workshop, The National Academies, December, 2011 † This talk is profiled in Betts, K. Environmental Health Perspectives, 120:A158165
- Panel Discussant on career opportunities for women in mathematics, NSF-George Washington University, Department of Mathematics, July, 2011
- Joint modeling of longitudinal and time to event data: An application to prospective pregnancy study, International Indian Statistical Association, April, NC State University, 2011
- Marginal estimation in multistage models. Biostatistics Workshop, University of Maryland, Baltimore County, March, 2011
- Marginal analysis of multistage models based on current status data, Seminar, Johns Hopkins University, May, 2010
- Modeling human fecundity: A survival analysis approach. George Mason University, December, 2009
- Statistical challenges in modeling human fecundity, IMS, Young Researchers Conference, 2009
- Statistical modeling of human fecundity, University of Chicago, November, 2008
- Analysis of recurrent events data in presence of terminal events, Department of Statistics, University of Connecticut, October, 2008
- Statistical Modeling of human fecundity at International Indian Statistical Association Conference, May 2008
- Robust inference for analysis of recurrent events data in presence of terminal events, Conference in Honor of Professor Hira Lal Koul, Michigan State University, May 2008
- Joint modeling of longitudinal and time to an event data: An application to human fecundity, University of Maryland, Baltimore County, May 2008
- Nonparametric inference in Multistage Models with Current Status Data at Probability and Statistics Day Conference held at University of Maryland Baltimore County, May 2007.
- Marginal estimation in multistate models with current status data at Biostatistics Branch, National Institute of Allergy and Infectious Diseases, December, 2006.
- Marginal estimation in multistate models with current status data at Office of Biostatistics Research, National Heart, Lung and Blood Institute, October 2006.
- Transformation Models for Recurrent Events Processes, Division of epidemiology, statistics and prevention research, National Institute of Child Health and Human Development, October, 2005.
- Semi-parametric Transformation Models for Recurrent Events Data, Department of Mathematics, University of Kansas, March, 2005
- Semi-parametric Inference in Proportional odds model with time-dependent covariates, Department of Statistics, University of Georgia, October, 2003.
- Estimation in two sample doubly censored scale model, Department of Mathematics, University of Nevada, Las Vegas, February, 1999.
Oral Presentations at Scientific meetings
- JSM 2010 on “Joint modeling of menstrual cycle and time to pregnancy”
- JSM 2008 on “Semi-parametric regression of censored data incorporating both short term and long term covariate effects”
- JSM 2007 on “Quantile regression analysis of recurrent events data”
- ENAR 2007 on “Robust analysis of recurrent events data in presence of terminal events"
- JSM 2006 on “Robust analysis of recurrent events data in presence of terminal events”
- ENAR 2005 on “Robust Inference for Censored Point Processes".
- ENAR 2004 on “Marginal Analysis of Multistage models based on current status data."
- JSM 2003 on “Semi-parametric Inference in Proportional odds model with time-dependent covariates.”
- ENAR 2002 on “Semi-parametric Inference in Proportional odds model with time-dependent covariates.”
- WNAR 2002 on “Semi-parametric Inference in Proportional odds model with time-dependent covariates.”
* denotes mentored paper.
- Rougoor CW, Sundaram, R, van Arendonk JAM. The relation between breeding management and 305-day milk production, determined via principal components regression and partial least squares. Livestock Production Science, 2000; 66: 71-83.
- Sundaram R. Estimation of scale parameter based on doubly censored samples. Journal of Statistical Planning and Inference, 2003; 115: 657-681.
- Brandon W, Troyer J, Sundaram R, Sun Y, Schoeps N, Walsh B. Medicaid enrollee switching among managed care plans. Journal of Health Care for the Poor and Underserved, 2005; 16:760-779.
- Sundaram R. Semi-parametric Inference in Proportional Odds Model with time-dependent covariates. Journal of Statistical Planning and Inference, 2006;136:320-334.
- Sundaram R. Estimation in two sample randomly truncated scale model. Journal of Statistical Planning and Inference, 2006; 136:2983-3006.
- Biswas A, Sundaram R. Kernel Survival function estimation based on doubly censored data. Communications in Statistics, Theory and Methods, 2006; 35:1293-1307. Authorship in alphabetical order.
- Datta S, Sundaram R. Nonparametric marginal estimation in a multistage model using current status data. Biometrics, 2006; 62: 829-837. Authorship in alphabetical order.
- Sundaram R. Robust Analysis of Recurrent Events in presence of terminal events. Invited paper for “Statistical Advances in the Bio-Medical Sciences: State of the art and future directions”, edited by Datta, Segal, Fine, Biswas; John Wiley and Sons, NJ, 2007.
- Sundaram R. Semi-parametric Inference in Proportional Odds Model with randomly truncated data. Journal of Statistical Planning and Inference, 2009; 139: 1381-1393.
- Sundaram R. Estimation in two sample randomly truncated scale model. Virtual Special Issue: Biostatistics & Statistical Bioinformatics, Elsevier Statistics Journal, 2008.
- Chang M, Parker E, Muller T, Haenen C, Mistry M, Finkielstain G, Murphy-Ryan M, Barnes K, Sundaram R, Baron J. Changes in cell cycle kinetics responsible for limiting somatic growth in mice. Pediatric Research 64: 240-245, 2008.
- Cooney M, Buck Louis G, Sundaram R, McGuiness BJ, Lynch CD. Validity of Self Reported Time-to-Pregnancy. Epidemiology 20: 56-59, 2008.
- Zhang J, Sundaram R, Sun W, Troendle J. Fetal Growth and Spontaneous Onset of Labor in Humans. American Journal of Epidemiology 168: 946-951, 2008.
- Brandon W, Sundaram R, Dunham A. Multiple switching in Medicaid managed care: A Proportional Hazards Model. Journal of Health Care for Poor and Underserved 20:1124-1141, 2009.
- Datta S, Lan L, Sundaram R. Nonparametric estimation of waiting time distributions in a Markov model based on current status data. Journal of Statistical Planning and Inference 13:2885-2897, 2009. Authorship in alphabetical order.
- *Hyun S, Sun Y, Sundaram. Assessing Cumulative Incidence Functions under the Semi-parametric Additive Risk Model. Statistics in Medicine 28:2748-2768, 2009.
- Sun Y, Sundaram R, Zhao Y. Empirical likelihood inference for the Cox model with time-dependent coefficients via local partial likelihood. Scandinavian Journal of Statistics 6:444-462, 2009. Authorship in alphabetical order.
- *Kim SD, Sundaram R, Louis GB. Joint modeling of intercourse behavior and human fecundability using Structural equation models. Biostatistics 11: 559-571, 2010.
- *Mikolajczyk R, Louis GB, Cooney M, Lynch C, Sundaram R. Characteristics of prospectively measured vaginal bleeding among women trying to conceive. Paediatric and Perinatal Epidemiology 24: 24-30, 2010.
- Murphy L, Gollenberg A, Louis GB, Kostyniak J, Sundaram R. Pre-Conception Polychlorinated Biphenyl Exposure and Infant Birth Weight. Environmental Health Perspectives 118: 297-302, 2010.
- Neta G, von Ehrenstein O, Lum K, Sundaram R, Zhang J. Risk association of cord blood cytokines with preterm delivery and small for gestational age infants. American Journal of Epidemiology 171:859-867, 2010.
- *Pollack A, Louis GB, Sundaram R, Lum K. Caffeine Consumption and Pregnancy Loss. Fertility and Sterility 93: 304-306, 2010.
- Zhang J, Troendle J, Mikolajczyk R, Sundaram R, Beaver J, Fraser W. The 1st Stage of Labor: 1959 – 1966. Obstetrics & Gynecology 115:705-710, 2010.
- Bloom M, Louis GMB, Sundaram R, Kostyniak J, Jain J. Metals and fecundity. Reproductive Toxicology 31:158-63, 2011.
- Buck Louis GM, Schisterman EF, Sweeney AM, Wilcosky TC, Gore-Langton R E, Lynch CD, Barr DB, Schrader SM, Kim S, Chen Z and Sundaram R. Designing Prospective Cohort Studies for Assessing Reproductive and Developmental Toxicity during Sensitive Windows of Human Reproduction and Development - the LIFE Study. Paediatric and Perinatal Epidemiology 25:413-424, 2011.
- Buck Louis GM, Rios LI, McLain A, Cooney M, Kostyniak P and Sundaram R. Persistent organochlorine pollutants and menstrual cycle length. Chemosphere 85(11):1742-8, 2011.
- Buck Louis GM, Lum K, Sundaram R, Chen Z, Kim S, Lynch C, Schisterman, EF and Pyper C. Stress reduces conception probabilities across the fertile window: Evidence in support of relaxation. Fertility and Sterility 95(7):2184-2189, 2011.
- Gollenberg A, Cooney M, Mumford S, Sundaram R, Louis GB. Validity of retrospectively reported behaviors during the periconception window. Journal of Reproductive Medicine Mar-Apr; 56(3-4):130-7, 2011.
- Louis GMB, Hediger M, Peterson M, Croughan M, Sundaram R, Stanford J, Chen Z, Fujimoto V, Varner M, Trumble A, Giudice L. Incidence of endometriosis by study population and diagnostic method: the ENDO Study. Fertility and Sterility 96:360-365, 2011.
- Louis GMB, Schisterman EF, Sweeney A, Wilcosky T, Gore-Langton R, Lynch C, Barr D, Schrader S, Kim SD, Chen Z, Sundaram R. Designing Prospective Cohort Studies for Assessing Reproductive and Developmental Toxicity during Sensitive Windows of Human Reproduction and Development- The LIFE Study. Paediatric and Perinatal Epidemiology 25:413-424,2011.
- *Lum K, Sundaram R, Louis GB. Women’s lifestyle behaviors while trying to become pregnant: evidence supporting preconception guidance. Am. J. Obstet. Gynecol. 205(3):203.e1-7, 2011.
- *McLain AC, Sundaram R., Cooney MA, Gollenberg AL, Buck Louis GM. Clustering of fecundability within women. Paediatric and Perinatal Epidemiology 25: 460–465, 2011.
- Buck Louis GM, Sundaram R, Schisterman EF, Sweeney AM, Lynch CD, Gore- Langton RE, Chen Z, Kim S, Caldwell K, & Barr DB. Heavy Metals and Couple Fecundity, the LIFE Study. Chemosphere 87:1201-1207, 2012.
- Kunisue T, Chen Z, Louis GMB, Sundaram R, Hediger ML, Sun L, Kannan K. Urinary Concentrations of Benzophenone-type UV Filters in the US Women from Two Cities and Their Association with Endometriosis. Environmental Science and Technology 46:4624-4632, 2012.
- Laughon SK, Zhang J, Grewal J, Sundaram R, Beaver J, Reddy U. Induction of Labor in Contemporary Obstetric Practice. Am. J. Obstet Gynecol 206:486.e1-9, 2012
- Louis GMB, Chen Z, Peterson CM, Hediger ML, Croughan MS, Sundaram R, Stanford JB, Varner MW, Fujimoto VY, Giudice LY, Trumble A, Parsons PJ, Kannan K. Persistent Lipophilic Environmental Chemicals and Endometriosis: The ENDO Study, 2007-2009. Environmental Health Perspectives 120:811-816, 2012.
- Louis GMB, Chen Z, Peterson CM, Hediger ML, Croughan MS, Sundaram R, Stanford JB, Varner MW, Fujimoto VY, Giudice LY, Trumble A, Parsons P J, Kannan K. Perfluorochemicals and Endometriosis: The ENDO Study. Epidemiology (in press)..
- Lynch CD, Sundaram R, Buck Louis GM, Lum KJ, Pyper C. Are increase levels of self-reported psychosocial stress, anxiety, and depression associated with fecundity? Fertility and Sterility (in press).
- *McLain AC, *Lum K., Sundaram R. A joint mixed effects dispersion model for menstrual cycle length and time-to-pregnancy. Biometrics, 68:648-656, 2012.
- *McLain AC, Sundaram R, Louis GMB. Modeling time to pregnancy in presence of sterile fraction using transformation survival model. Statistical methods in medical research (in press).
- Sundaram R, McLain A, Louis Buck G. A survival analysis approach to modeling human fecundity. Biostatistics. 13:4-17, 2012.
- Chason R, McLain AC, Sundaram R, Chen Z, Segars JH, Pyper C, Louis GMB. Preconception Stress and the Secondary Sex Ratio: A Prospective Cohort Study. Fertility and Sterility (in press).
- Thoma ME, Hediger ML, Sundaram R, Stanford JB, Peterson CM, Croughan MS, Chen Z, Louis GMB and the ENDO Study. Comparing “Apples and Pears:” Women’s perceptions of their body size and shape. Journal of Women’s Health (in press).
- *Kim SD, Sundaram R, Louis GMB. Flexible Bayesian Human Fecundity Models. Bayesian Analysis (in press). Invited for discussion.
- Louis GMB, Sundaram R, Schisterman, E., Maisog, J., Kim, S. D., Chen, Z., Sweeney, A. Persistent organochlorine compounds and Time to pregnancy. Environmental Health Perspectives (provisionally accepted).
- Sundaram R, Balakrishnan N. Semi-parametric inference for competing risks data. Methods and applications of statistics in life and health sciences, Chapter 67, 749-765, Eds. Balakrishnan, N. Read, C. B., Vidakovic, B., Kotz, S., Johnson, N. L.; John Wiley and Sons, NJ, 2009.
- Sundaram R, Louis GMB, Kim SD. Statistical modeling of human fecundity. Methods and applications of statistics in life and health sciences, Chapter 73, pages 815833, Eds. Balakrishnan, N. Read, C. B., Vidakovic, B., Kotz, S., Johnson, N. L.; John Wiley and Sons, NJ, 2009.
- Louis GMB, Sundaram R. Exposome: time for transformative research. Statistics in Medicine (in press).
- Albert PS, Sundaram R, McLain A. Innovative approaches to analyzing longitudinal data with missingness using shared parameter models. Lecture notes in Statistics.
Manuscripts under review:
- *Mclain AC, Sundaram R, Louis GMB. Prediction of longitudinal binary data with informative dropout: A joint modeling approach.
- Laughon SK, McLain AC, Sundaram R, Catov J, Louis GMB. Maternal lipid change in relation to length of gestation: a prospective cohort study with preconception enrollment of women.
- Thoma ME, McLain AC, Louis JF, King RB, Trumble A, Sundaram R, Louis GMB. The prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach.
- Sundaram R, Lynch C, Kissell K, Mclain AC, Pyper C, Louis GMB. Stress and menstrual cycle characteristics.
Manuscripts in preparation:
- Sundaram R, Ghoshal S, Mclain AC. Statistical inference of median cost associated with recurrent hospitalizations in presence of terminal event.
- Lynch C, Sundaram R, Maisog J, Sweeney A, Louis GMB. Increased levels of physiologic stress are associated with decreased fecundability: results from a couple-based prospective study, The LIFE Study.
- Mumford S, Sundaram R, Schisterman E, Maisog J, Chen Z, Kim S, Sweeney A, Louis GMB. Phytoestrogens and time-to-pregnancy.
- Katki H, Sundaram R, Wacholder S. A joint model of HPV tests and cervical cancer for potential use in developing cancer screening guidelines.
Work in progress:
- Sundaram R, Biswas A, Grewal J, Laughon S, Reddy U. A multistage model approach to modeling functional data, with application to human labor curves.
- Lum K, Sundaram R, Louis T. Incorporating Sampling Plan and Competing Risks in Analysis of Prospective Pregnancy Studies.
- *Nsoesie E, Sundaram R. Modeling digit preference in self-reported data in pregnancy studies.
- Sundaram R, Louis GMB. Accounting for heterogeneous fertile window in modeling fecundability.
- Sundaram, R. Louis, G.M.B. An elastic-net approach to variable selection with discrete survival data: An application to chemicals and time to pregnancy studies.