Curriculum Vitae, L.A. (George) Sjaarda

BIOGRAPHICAL

Name: Lindsey A. Sjaarda, PhD (maiden name: George)
E-mail: lindsey.sjaarda@nih.gov

EDUCATION AND TRAINING

UNDERGRADUATE:

2001-2005 Virginia Polytechnic Institute and State University, Blacksburg, VA
B.S. Summa Cum Laude Honors Scholar GPA: 3.92
Animal and Poultry Science

GRADUATE:

2005-2007 Virginia Polytechnic Institute and State University, Blacksburg, VA
M.S. Summa Cum Laude GPA: 3.83
Animal and Poultry Science, Equine Nutrition. Mentors: Ray Geor, PhD, DACVIM & W. Burt Staniar, P hD
2007-2010 University of Wyoming, Laramie, WY
Ph.D. Summa Cum Laude GPA: 4.00
Reproductive Biology, Developmental Origins of Disease Mentor: Stephen Ford, PhD

POST-GRADUATE TRAINING:

2010-2012 University of Pittsburgh School of Medicine, Pittsburgh PA
Postdoctoral Research Associate
Pediatrics, Weight Management & Wellness Mentors: Silva Arslanian, MD & H yagriv Simhan, MD
2012-current Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health North Bethesda, MD
Postdoctoral Fellow, Intramural Research Training Award
Epidemiology Mentors: Sunni Mumford, PhD & S . Katherine Laughon, MD

MEMBERSHIPS in PROFESSIONAL SOCIETIES

2007-2009 Equine Science Society, member
2008-2009 American Society of Animal Science, member
2009-2010 Society for the Study of Reproduction, member
2010-current Endocrine Society, member
2011-current The Obesity Society, member
2012-current American Society for Nutrition

HONORS

2004 Saacke Reproductive Physiology Scholarship, Department of Animal and Poultry Science, Virginia Tech Awarded to the student achieving the highest grade in the Reproductive Physiology course annually
2004 John Lee Pratt Rising Senior Nutrition Research Scholarship, Virginia Tech Awarded annually by the College of Agriculture and Life Sciences to support senior research projects in animal nutrition based on the submission of a research proposal
2005 Honors Scholar diploma, Virginia Tech Awarded to University Honors graduates maintaining a minimum GPA of 3.5 all semesters and completing 18 hours of Honors courses
2005 Virginia Tech B.S. with highest honors, summa cum laude
2005 The Outstanding Senior, Virginia Tech College of Agriculture and Life Sciences Awarded to one graduating senior from each college of the University for the recognition of exceptional performance and service
2007 Virginia Tech M.S. with highest honors, summa cum laude
2008 Best Oral Presentation, University of Wyoming Graduate Student Symposium
2008 Mary Mead Graduate Award for Women in Agriculture, Brand of Excellence Scholarship Committee, College of Agriculture, University of Wyoming
2010 University of Wyoming Ph.D. with highest honors, summa cum laude
2011 Thrasher Research Fund Early Career Award, $26,730 grant support

PUBLICATIONS

ARTICLES in REFEREED JOURNALS

  1. Staniar WB, Cubitt TA, George LA, Harris PA, Geor RJ. Glucose and insulin responses to different dietary energy sources in Thoroughbred broodmares grazing cool season pasture. Livestock Science. 2007;111:164-171. [doi:10.1016/j.livsci.2007.01.148]

  2. Carter RA, McCutcheon LJ, George LA. Smith TL, Frank N, Geor RJ. Effects of diet-induced weight gain on insulin sensitivity and plasma hormone and lipid concentrations in horses. American Journal of Veterinary Research. 2009;70(10):1250-1258. PMID: 19795940

  3. George LA, Staniar WB, Treiber KH, Harris PA, Geor RJ. Insulin sensitivity and glucose dynamics during pre-weaning foal development and in response to maternal diet composition. Domestic Animal Endocrinology. 2009;37:23-29. PMID: 19359126

  4. George LA, Staniar WB, Cubitt TA, Treiber KH, Harris PA, Geor RJ. Evaluation of the effects of pregnancy on insulin sensitivity, insulin secretion, and glucose dynamics in Thoroughbred mares. American Journal of Veterinary Research. 2010;72(5):666-674. PMID: 21529219

  5. George LA. Uthlaut AB, Long NM, Zhang L, Ma Y, Smith DT, Nathanielsz PW, Ford SP. Different levels of overnutrition and weight gain during pregnancy have differential effects on fetal growth and organ development. Reproductive Biology and Endocrinology. 2010;8:75. PMID: 20576133

  6. Long NM, George LA, Uthlaut AB, Smith DT, Nijland MJ, Nathanielsz PW Ford SP. Maternal obesity and increased nutrient intake before and during gestation in the ewe results in altered growth, adiposity, and glucose tolerance in adult offspring. Journal of Animal Science. 2010;88(11):3546-3553. PMID: 20622177

  7. George LA, Bacha F, Lee S, Tfayli H, Andreatta E, Arslanian S. Surrogate estimates of insulin sensitivity in obese youth along the spectrum of glucose tolerance from normal to prediabetes to diabetes. Journal of Clinical Endocrinology and Metabolism. 2011;96(7):2136-2145. PMID: 21508130

  8. George LA, Zhang L, Tuersunjiang N, Ma Y, Long NM, Uthlaut AB, Smith DT, Nathanielsz PW, Ford SP. Early maternal undernutrition programs increased feed intake, altered glucose metabolism and insulin secretion, and liver function in aged female offspring. The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2012:302:R795R804. PMID: 22277936.

  9. George Sjaarda L, Bacha F, Lee S, Tfayli H, Andreatta E, Arslanian S. Oral disposition index in obese youth across the gamut of glucose tolerance from normal to prediabetes to diabetes: relationship to clamp disposition index. Journal of Pediatrics. 2012:161:51-57. PMID: 22325254.

  10. Sjaarda LA, Michaliszyn SF, Lee S, Tfayli H, Bacha F, Farchoukh L, Arslanian S. HbA1c diagnostic categories and β-cell function relative to insulin sensitivity in overweight/obese adolescents. Diabetes Care, Accepted July 2012.

ABSTRACTS

  1. George L, Staniar WB, Harris P, Geor R. Insulin sensitivity and glucose dynamics in neonatal foals. Poster presentation, Experimental Biology, Washington, D.C. April 2007.

  2. George LA, Staniar WB, Treiber KH, Harris PA, Geor RJ. Insulin sensitivity and glucose dynamics in foals as influenced by age and maternal diet during gestation. Oral presentation, Equine Science Society Symposium, Hunt Valley, MD. June 2007.

  3. George LA, Staniar WB, Cubitt TA, Treiber KH, Harris PA, Geor RJ. Nutritional effects on insulin sensitivity and glucose dynamics in pregnant and non-pregnant mares. Oral presentation, Equine Science Society Symposium, Hunt Valley, MD. June 2007.

  4. Ford SP, George LA, Iroz AN, Hess BW, Moss GE, Nathanielsz PW. Maternal obesity combined with high plane of nutrition during pregnancy alters glucose tolerance of the ewe and her offspring. Society for Gynecological Investigation, San Diego, CA. March 2008.

  5. George LA, Nathanielsz PW, Ford SP. Increased circulating progesterone levels during the estrous cycle in offspring of nutrient restricted ewes. Oral presentation, American Society of Animal Science, Indianapolis, IN. July 2008.

  6. Nijland MJ, Burt BE, George LA, Nathanielsz PW, Ford SP. Maternal nutrient restriction in sheep during early gestation depresses offspring hypothalamo-pituitary-adrenal axis stress response but not pituitary responses to CRH/AVP or adrenal response to ACTH. Society for Gynecological Investigation, Glasgow, Scotland. March 2009.

  7. Ford SP, Burt BE, George LA, Nathanielsz PW. Decreased maternal nutrition in the first half of pregnancy impairs ovarian progesterone secretion and decreases fertility in offspring. Society for Gynecological Investigation, Glasgow, Scotland. March 2009.

  8. Ford SP, Smith DT, Long NM, Uthlaut AB, George LA, Nathanielsz PW. Nijland MJ. Maternal obesity and nutritional excess results in delivery of lambs with increased body fat and impaired pancreatic function at birth. Society for Gynecological Investigation, Glasgow, Scotland. March 2009.

  9. George LA, Uthlaut AB, Long NM, Nathanielsz PW, Ford SP. Effects of diet-induced weight gain prior to and during pregnancy on body fat deposition and insulin sensitivity. Oral presentation, Society for the Study of Reproduction, Pittsburgh, PA. July 2009.

  10. George LA, Uthlaut AB, Zhang L, Long NM, Nathanielsz PW, Ford SP. Maternal nutrient restriction in first half of pregnancy results in thrifty phenotype in aged ewes. Poster presentation, Society for Gynecologic Investigation, Orlando, FL. March 2010.

  11. George LA, Uthlaut AB, Long NM, Nathanielsz PW, Ford SP. Fetal growth and organ development at mid-gestation resulting from differing levels of maternal overnutrition. Poster presentation, Society for Gynecologic Investigation, Orlando, FL. March 2010.

  12. Ford SP, Zhang L, George LA, Ma Y, Long NM, Uthlaut AB, Nathanielsz PW. Maternal malnutrition induces metabolic reprogramming in offspring. ADSA PSA AMPA CSAS ASAS Joint Annual Meeting, Denver, CO. July 2010.

  13. Zhang L, Ma Y, Tuersunjiang N, George LA, Ford SP, Nathanielsz PW. Maternal nutrient restriction upregulates phosphoenolpyruvate carboxykinase expression in the livers of aged female offspring. ADSA PSA AMPA CSAS ASAS Joint Annual Meeting, Denver, CO. July 2010.

  14. Zhang L, George LA, Ford SP, Nathanielsz PW. Maternal nutrient restriction from early to mid-gestation increases pancreatic beta-cell number at mid-gestation but pancreatic weight and beta-cell numbers are reduced by late-gestation. ADSA PSA AMPA CSAS ASAS Joint Annual Meeting, Denver, CO. July 2010.

  15. George L, Bacha F, Lee S, Tfayli H, Andreatta E, Arslanian S. Surrogate indices of β-cell function in obese youth with NGT, IGT and diabetes. Oral presentation, American Diabetes Association, San Diego, CA. June 2011.

  16. Sjaarda L, Lee S, Bacha F, Tfayli H, Andreatta E, Arslanian S. Measuring beta-cell function relative to insulin sensitivity in pediatric research: does the hyperglycemic clamp suffice? Poster presentation, American Diabetes Association, Philadelphia, PA. June 2012.

  17. Sjaarda L, Lee S, Tfayli H, Bacha F, Andreatta E, Arslanian S. HbA1c diagnostic categories and β-cell function relative to insulin sensitivity in overweight/obese adolescents. Oral presentation, American Diabetes Association, Philadelphia, PA. June 2012.

  18. Sjaarda L, Scifres C, Bodnar L, Simhan H, Arslanian S. Infant growth and adiposity between 6 and 18 months of age: what are the maternal and infant determinants? Accepted, Poster presentation, The Obesity Society, San Antonio, TX. September 2012.

OTHER PUBLICATIONS

  1. George LA. Insulin and glucose dynamics in mature ewes born from nutrient restricted dams. UW Department of Animal Science, Annual research report. 2007.

  2. George LA, Nathanielsz PW, Ford SP. Increased circulating progesterone levels in the offspring of nutrient restricted ewes. UW Department of Animal Science, Annual research report. 2008.

  3. George LA, Uthlaut AB, Long NM, Smith DT, Nathanielsz PW, Ford SP. Effects of different dietary levels prior to and during pregnancy on maternal adiposity, insulin sensitivity and fetal growth in the ewe. UW Department of Animal Science, Annual research report. 2009.

  4. George LA, Uthlaut AB, Long NM, Zhang L, Smith DT, Nathanielsz PW, Ford SP. Feed intake and glucose metabolism in adult offspring of nutrient restricted ewes. UW Department of Animal Science, Annual research report. 2009.

PROFESSIONAL ACTIVITIES

TEACHING

Classroom Instruction:

Virginia Tech
2005 Animal Agriculture (AT 0164)
Role: Graduate teaching assistant, graded class quizzes and exams
2005 Horse Management (AT 0624)
Role: Undergraduate teaching assistant, aided in administration and grading of quizzes and exams; delivered lecture describing equine dentition and dental care
2006 Horse Management (AT 0624)
Role: Delivered lecture on applied equine feeding management
University of Wyoming
2008 Comparative Anatomy and Physiology (ANSC 3010)
Role: Taught course section on anatomy and physiology of the gastrointestinal tract (3 lecture series) and prepared relevant exam questions; assisted regularly in laboratory teaching and dissections

Advisees:

Virginia Tech
2006 Jonathan Myers, undergraduate summer research intern
Project title: Insulin sensitivity and glucose dynamics during pre-weaning foal development and in response to maternal diet composition
University of Wyoming
2008 Rehan Muhammad, Summer Research Apprentice Program
Project title: Maternal adiposity and fetal health

RESEARCH

Grant Support:

10/1/2011 – 9/30/2012 Thrasher Research Fund Early Career Award
The Healthy Infants Postpartum (HIP) Study: A pilot study of growth and body composition in infancy $26,730, #NR-0157

Invited Lectures and Other Scholarly Presentations:

Dietary energy composition affects the somatotropic axis in mares. John Lee Pratt Rising Senior Nutrition Research Symposium, Virginia Tech, 2005.

Increased circulating progesterone levels during the estrous cycle in offspring of nutrient restricted ewes. University of Wyoming Graduate Student Symposium, 2008.

Cow age mediates the impact of maternal undernutrition on fetal growth and organ development. Poster presentation, Colorado Nutrition Round Table, 2008.

Using animal models to understand the fetal origins of disease. Invited seminar, Animal and Dairy Science Department, Pennsylvania State University, 2009.

Developmental origins of disease: learning from animal models. Invited seminar, Virginia Tech Middleburg Agricultural Research and Extension Center, 2011.

Scholarly Journals

2011 to present European Journal of Obstetrics & Gynecology and Reproductive Biology Ad Hoc Reviewer

CURRENT RESEARCH INTERESTS

Developmental origins of obesity, insulin resistance and type 2 diabetes

Effects of perinatal maternal obesity and diet on chronic disease risk in offspring

Maternal obesity, diet and dysmetabolism in pregnancy predicting risk for disease postpartum

Postnatal environmental influences on development of childhood obesity and dysmetabolism

Development of perinatal interventions to reduce future disease risk in mother and offspring

SERVICE

Community:

2007-2011 “Big Sister”
Big Brothers Big Sisters Volunteer
2010 Big Sister of the Year, Laramie WY chapter