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OD Research - Reproductive Epidemiology
Endometriosis: Natural History, Diagnosis, and Outcomes (ENDO Study)
The ENDO Study utilizes a matched exposure cohort design for purposes of assessing environmental chemicals, lifestyle and medical history in relation to the development of endometriosis. An operative cohort comprising 625 women undergoing laparoscopy or laparotomy was recruited for participation. Baseline interviews and anthropometric assessments were performed with all women followed by the collection of blood and urine samples. Surgeons obtained peritoneal fluid, omentum fat and endometrial biospies, and also completed standardized operative forms to capture postoperative diagnoses and findings. The operative cohort was matched to the population residing within a 50-mile catchment area of participating clinical sites to obtain a cohort of women of reproductive age without a known history of endometriosis. Participating women complete the baseline interview, anthropometric assessment and provide blood and urine samples. They also underwent a pelvic MRI to identify endometriosis or other gynecologic pathology.
Germaine Louis, Ph.D., M.S.
- Buck Louis GM, Chen Z, Peterson CM, Hediger ML, Croughan MS, Sundaram R, Stanford JB, Varner MW, Fujimoto VY, Giudice LC, Trumble A, Parsons PJ, Kannan K. Persistent lipophilic environmental chemicals and endometriosis: The ENDO Study, 2007-2009. Environmental Health Perspectives 2012; 120(6):811-816. PMID: 22417635
- Kunisue T, Chen Z, Buck Louis GM, Sundaram R, Hediger ML, Sun L, Kannan K. Urinary concentrations of benzophenone-type UV filters in U.S. women and their association with endometriosis. Environmental Science and Technology 2012; 46:4624-4632. PMID: 22417702
- Schliep KC, Stanford JB, Zhang B, Chen Z, Dorais JK, Johnstone EB, Hammoud AO, Varner MW, Buck Louis GM. Inter- and intra-reliability in the diagnosis and staging of endometriosis: the ENDO Study. Obstetrics and Gynecology 2012; 120(1):104-112. PMID: 22914398