As HIV research has become more global in nature, research gaps in children and pregnant women related to many HIV-associated co-infections, such as tuberculosis (TB), hepatitis, and malaria, have become evident. The MPIDB has responded by promoting and funding new research related to these HIV-associated infectious pathogens.
Additionally, the National Institute of Allergy and Infectious Diseases–NICHD-funded International Maternal, Pediatric, Adolescent AIDS Clinical Trials (IMPAACT) Network has broadened its focus to include TB, malaria, hepatitis, and investigation of vaccines to prevent HIV-related or other high-priority infectious diseases in children, adolescents, and pregnant women. The MPIDB is increasing its research portfolio in infectious diseases, initially focusing on TB, malaria, and hepatitis.
Examples of current research include:
The MPIDB is also expanding its research portfolio to address the major infectious causes of morbidity and mortality in children worldwide. Although great strides have been made in reducing infectious mortality in children in resource-limited countries, infections continue to be a leading cause of child mortality in such settings. Globally, in 2012, approximately 6.6 million children younger than age 5 years died; infectious diseases such as pneumonia, diarrhea and malaria are the leading causes of mortality in children under age 5 years. Infections acquired in utero or in the immediate postnatal period play a prominent role in perinatal and childhood morbidity and mortality. A number of these infections may be mild or subclinical for the mother; nevertheless, vertical transmission can result in devastating consequences for the infant.
Areas of interest include the following aspects of infectious diseases with high morbidity and mortality rates in pediatric and maternal populations:
Examples of relevant diseases include:
The MPIDB is interested in receiving new grants to study these causes of mortality, including epidemiology, diagnosis, treatment, and prevention. Investigators are invited to contact MPIDB staff members to discuss whether their research is relevant to the MPIDB’s expanding research portfolio.
All related topics
All related news
All related FOAs