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NIH/ACC 2001 Scientific Conference Agenda Potential Cellular & Molecular Mechanisms in Autism & Related Disorders

Sponsored by NICHD and NIEHS, NIMH, NINDS, NIDCD, and the Office of Rare Diseases

September 6-7, 2001

Bethesda Marriott, Bethesda, Maryland

September 6, 2001

8:30 - 9:00 a.m.	Welcome & Introductions NIH Directors Duane Alexander, NICHD Kenneth Olden, NIEHS Steven Hyman, NIMH Audrey Penn, NINDS James Battey, NIDCD Overview Conference Co-Chairs Jean Lauder, University of North Carolina Marie Bristol Power, NICHD Cindy Lawler, NIEHS

Autism and Related Disorders

8:50 - 9:00 a.m.	Overview
9:00 -10:20 a.m.	Session 1: Neuropathology of Autism: Chair, Anthony Bailey Neuroanatomical Correlates of Autism Anthony Bailey Dysregulation of Reelin Protein in Autism S. Hossein Fatemi Cerebellar Neuropathology and Autistic Behaviors: Exploration of a Mouse Model System Daniel Goldowitz Reduced Number of Benzodiazepine Binding Sites and Decreased Density of GABAA Receptors in Hippocampal Formation of Autistic Individuals Gene J. Blatt
10:20 - 10:35 a.m.	Discussion
10:35-10:50 a.m.	Coffee Break Sponsored by the ASA Foundation
10:50 - 11:30 a.m.	Session 2: Cognitive and Social Phenotypes in Autism: Chair, Joseph Piven Human Research Social Intelligence in Normal and Autistic Brain Helen Tager-Flusberg fMRI Evidence for Differences in Social Affective Processing in Autism Robert Schultz
11:30 - 11:45 a.m.	Discussion
11:45 - 1:00 a.m.	Working Lunch
1:00 - 2:00 a.m.	Animal Models Social Interaction Abnormalities in Mice Lacking Dvl1 Anthony Wynshaw-Boris Social Deficits in Oxytocin Knockout Mice Larry Young The Primate Temporal Lobe Structures: Maturation, Early Dysfunction, and Relationships to Human Developmental Disorders Jocelyne Bachevalier
2:00 - 2:15 p.m.	Discussion
2:15 - 3:15 p.m.	Session 3: Molecular Genetics of Autism: Chair, Edwin Cook Functional and Positional Candidate Gene Studies of Autism Edwin Cook Evidence Supporting Wnt2 as an Autism Susceptibility Gene Thomas Wassink Rett Syndrome, MECP2 Mutations, and Autism Ignatia Van den Veyver
3:15 - 3:30 p.m.	Break
3:30 - 4:30 p.m.	Cellular Substrates of Fragile X Syndrome William T. Greenough Brain Abnormalities in a Mouse Model for Smith-Lemli-Opitz Syndrome: Implications for Autism Heather Baudet and Kathy Sulik Ch 15q 22-23 Deletion in Autism and Evidence for Location of Two Series of Chromosome 15 Specific Duplicons that Predispose to Chromosome Rearrangements Moyra Smith
4:30 - 4:45 p.m.	Discussion
4:45 - 5:00 p.m.	General Discussion
6:30 p.m.	Working Dinner (Session chairs and speakers only - reports)

September 7, 2001

8:00-9:40 a.m.	Session 4: Neurotransmitters Systems in Autism: Chair, Jean Lauder Abnormal Serotonin Synthesis and GABAA Receptors Measure with PET in Autistic Children Diane C. Chugani Prenatal Serotonin in Rats as an Animal Model of Autism Patricia Whitaker-Azmitia Chronic Elevation of Serotonin and Norepinephrine in MAO-A and MAO-A/B Deficient Mice Daniel Holschneider Control of Central Serotonergic Neuron Phenotype by the ETS Domain Factor PET-1 Evan Deneris Characteristics of Mice Lacking the gabrb3 Gene Timothy DeLorey
9:40 - 9:55 a.m.	Discussion
9:55 -10:10 a.m.	Break

8:00-9:40 a.m.

Session 4: Neurotransmitters Systems in Autism: Chair, Jean Lauder

Abnormal Serotonin Synthesis and GABAA Receptors Measure with PET in Autistic Children
Diane C. Chugani

Prenatal Serotonin in Rats as an Animal Model of Autism
Patricia Whitaker-Azmitia

Chronic Elevation of Serotonin and Norepinephrine in MAO-A and MAO-A/B Deficient Mice
Daniel Holschneider

Control of Central Serotonergic Neuron Phenotype by the ETS Domain Factor PET-1
Evan Deneris

Characteristics of Mice Lacking the gabrb3 Gene
Timothy DeLorey

9:40 - 9:55 a.m.

Discussion

9:55 -10:10 a.m.

Break

Role of the Environment in Autism

10:10 - 12:10 a.m.	Session 5: Environmental Influences as Etiologic Factors in Autism: Chair, Stanley Barone Developing Neurotransmitter Systems as Targets for Pesticide Exposure Jean Lauder Environmental Insults and Early Developmental Genes in Autism Etiology Patricia Rodier Regulation of Neurogenesis by Growth Factors and Neurotoxicants Emanuel DiCicco-Bloom Disruption of Synaptic Neural Cell Adhesion Molecules by Environmental Insults Kenneth Reuhl Multidisciplinary Analysis of the BDV Animal Model of Autism: Neuroanatomical, Neurochemical, Behavioral, and Genetic Features Mikhail Pletnikov Possible Environmental Risk Factors in the Etiology of Autism Isaac Pessah
12:10 - 12:25 a.m.	Discussion
12:25 - 1:20 a.m.	Working Lunch Sponsored by the Autism Tissue Program

10:10 - 12:10 a.m.

Session 5: Environmental Influences as Etiologic Factors in Autism: Chair, Stanley Barone

Developing Neurotransmitter Systems as Targets for Pesticide Exposure
Jean Lauder

Environmental Insults and Early Developmental Genes in Autism Etiology
Patricia Rodier

Regulation of Neurogenesis by Growth Factors and Neurotoxicants
Emanuel DiCicco-Bloom

Disruption of Synaptic Neural Cell Adhesion Molecules by Environmental Insults
Kenneth Reuhl

Multidisciplinary Analysis of the BDV Animal Model of Autism: Neuroanatomical, Neurochemical, Behavioral, and Genetic Features
Mikhail Pletnikov

Possible Environmental Risk Factors in the Etiology of Autism
Isaac Pessah

12:10 - 12:25 a.m.

Discussion

12:25 - 1:20 a.m.

Working Lunch
Sponsored by the Autism Tissue Program

Emerging Technologies and Strategies in Autism Research

1:20 - 2:40 p.m.	Session 6: Emerging Technologies: Chair, Clarence Schutt Gene-based Mutagenesis for Functional Annotation in the Mouse Terry Magnuson Metabonomics Jeremy Nicholson Microdissection and Laser Capture Micromanipulation Chi'ming Huang Structural Biology in Autism Research Clarence Schutt

2:40 - 2:55 p.m.	Discussion
2:55 - 3:10 p.m.	Coffee Break Sponsored by the National Association for Autism Research (NAAR)
3:10 - 4:00 p.m.	Session 7: Autism Brain Tissue Panel-Progress and Future Strategies: Chair, Jane Pickett Brain and Tissue Donation - Issues Related to Children Ronald Zielke Neuropathology Margaret Bauman Microarrays in Human Tissue/Tuberous Sclerosis/Seizures Peter Crino Tissue Based Data Warehousing to Maximize Collaboration by Divergent Laboratories Harry Haroutunian Immunohistochemistry Robert Lopez
4:00 - 4:15 p.m.	Discussion
4:15 - 4:40 p.m.	Reports of Recommendations from Working Groups
4:40 - 5:00 p.m.	Discussion of Reports from Working Groups

We would like to thank Jack Bishop, William McMahon, and Ute Schambra for serving as conference discussants

We would like to thank the Autism Tissue Program, The National Association for Autism Research (NAAR), and the ASA Foundation for sponsoring the refreshments for this conference.

Last Updated Date: 11/30/2012